Anthrax Cases in Pregnant and Postpartum Women

Meaney‐Delman, Dana; Zotti, Marianne E.; Rasmussen, Sonja A.; Strasser, Sheryl; Shadomy, Sean V.; Turcios-Ruiz, Reina M.; Wendel, George D.; Treadwell, Tracee A.; Jamieson, Denise J.

doi:10.1097/aog.0b013e318270ec08

“…9 A historical analysis of published anthrax cases in pregnant women confirmed that this infection can result in maternal death and fetal deaths. 10 Taken together, these data suggest pregnant women are at-risk for morbidity and mortality if infected with B. anthracis and highlight the importance of post-exposure prophylaxis and treatment of anthrax in pregnant women.…”

Section: Introductionmentioning

confidence: 75%

Prophylaxis and Treatment of Anthrax in Pregnant Women

Meaney‐Delman¹,

Rasmussen²,

Beigi³

et al. 2013

Obstetrics &Amp; Gynecology

Self Cite

View full text Add to dashboard Cite

Objective To review the safety and pharmacokinetics of antibiotics recommended for anthrax post-exposure prophylaxis and treatment in pregnant women. Data Sources Articles were identified in the PUBMED database from inception through December 2012 by searching the keywords ([“pregnancy]” and [generic antibiotic name]). Additionally, hand searches of references from REPROTOX, TERIS, review articles and Briggs’ Drugs in Pregnancy and Lactation were performed. Methods of Study Selection Articles included in the review contain primary data related to the safety and pharmacokinetics among pregnant women of five antibiotics recommended for anthrax post-exposure prophylaxis and treatment (ciprofloxacin, levofloxacin, moxifloxacin, doxycycline, amoxicillin), and of nine additional antibiotics recommended as part of the treatment regimen (penicillin, ampicillin, linezolid, clindamycin, meropenem, doripenem, rifampin, chloramphenicol, or vancomycin). Tabulation, Integration and Results The PUBMED search identified 3850 articles for review. Reference hand searching yielded nine additional articles. In total, 112 articles met the inclusion criteria. Conclusions Overall, safety and pharmacokinetic information is limited for these antibiotics. Although small increases in risks for certain anomalies have been observed with some antibiotics recommended for prophylaxis and treatment of anthrax, the absolute risk of these antibiotics appears low. Given the high morbidity and mortality associated with anthrax, antibiotics should be dosed appropriately to ensure that antibiotic levels can be achieved and sustained. Dosing adjustments may be necessary for the beta lactam antibiotics and the fluoroquinolones to achieve therapeutic levels in pregnant women. Data indicate that the beta lactam antibiotics, the fluoroquinolones, and, to a lesser extent, clindamycin enter the fetal compartment, an important consideration in the treatment of anthrax, as these antibiotics may provide additional fetal benefit in the 2nd and 3rd trimesters of pregnancy. Additional well designed safety and pharmacokinetic studies are needed.

show abstract

“…They stated that 16 women and 12 babies died; however, the fatal cases belonged to the pre-antibiotic period. In that particular review, anthrax was found to be associated with high maternal and foetal mortality rates both before and after the delivery [9]. In Iran, a pregnant woman who was followed-up for eyelid anthrax died due to excessive oedema and dyspnoea.…”

Section: Discussionmentioning

confidence: 99%

“…There are limited numbers of cases in the literature describing anthrax in pregnant women [6][7][8][9]. The complications in mother and baby and their management are unclear.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cutaneous Anthrax on Eyelid in a Pregnant Woman

Parlak¹,

Ertürk²,

Erol³

et al. 2016

Eurasian J Med

1

0

View full text Add to dashboard Cite

A 32-year-old patient who was 17 weeks of pregnant referred to our hospital due to a lesion on the eyelid and swelling on her face. Patient's history revealed that she helped her husband for slaughtering of a sick animal and contacted with the meat. A scabby lesion was detected on the inferior eyelid with hyperaemia around, central necrotic appearance and swelling. The diagnosis of anthrax was performed based on her epidemiological data, physical examination findings, and Bacillus anthracis were seen on direct preparation. This case was considered worthy to present since she was pregnant, the disease was located on the inferior eyelid, which is a rare place for location, and caused no complication or sequel either in mother or in baby.Keywords: Bacillus anthracis, cutaneous anthrax, eyelid, pregnancy, zoonosis ÖzOtuz iki yaşında ve 17 haftalık gebe olan hasta, göz kapağında yara ve tüm yüzünde şişlik şikâyetleri ile hastanemize sevk edildi. Hastanın hikâyesinden eşiyle hasta hayvan kesimine katıldığı, ete temas ettiği öğrenildi. Sağ göz alt kapağında kenarları hiperemik ortası nekroze görünümlü krutlu lezyon ve tüm yüzde boyuna kadar yayılan ödem saptandı. Antibiyotik kullanan hastanın kül-türlerinde üreme olmadı. Şarbon tanısı, epidemiyolojik hikâyesi, fizik muayene bulgusu ve direkt preparatta Bacillus anthracis görülmesi ile konuldu. Hastanın tedavisi için on gün penisilin verildi. Bu olgu, hastanın gebe olması, ender bir yerleşim olan alt göz kapağına yerleşmesi, anne ve bebekte herhangi bir komplikasyon ve sekele neden olmaması nedeniyle sunulmaya değer bulunmuştur.

show abstract

“…There are limited numbers of cases in the literature describing anthrax in pregnant women [6][7][8][9]. The complications in mother and baby and their management are unclear.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Anthrax on Eyelid in a Pregnant Woman

Parlak¹,

Ertürk²,

Erol³

et al. 2015

Eurasian J Med

0

View full text Add to dashboard Cite

A 32-year-old patient who was 17 weeks of pregnant referred to our hospital due to a lesion on the eyelid and swelling on her face. Patient's history revealed that she helped her husband for slaughtering of a sick animal and contacted with the meat. A scabby lesion was detected on the inferior eyelid with hyperaemia around, central necrotic appearance and swelling. The diagnosis of anthrax was performed based on her epidemiological data, physical examination findings, and Bacillus anthracis were seen on direct preparation. This case was considered worthy to present since she was pregnant, the disease was located on the inferior eyelid, which is a rare place for location, and caused no complication or sequel either in mother or in baby.Keywords: Bacillus anthracis, cutaneous anthrax, eyelid, pregnancy, zoonosis ÖzOtuz iki yaşında ve 17 haftalık gebe olan hasta, göz kapağında yara ve tüm yüzünde şişlik şikâyetleri ile hastanemize sevk edildi. Hastanın hikâyesinden eşiyle hasta hayvan kesimine katıldığı, ete temas ettiği öğrenildi. Sağ göz alt kapağında kenarları hiperemik ortası nekroze görünümlü krutlu lezyon ve tüm yüzde boyuna kadar yayılan ödem saptandı. Antibiyotik kullanan hastanın kül-türlerinde üreme olmadı. Şarbon tanısı, epidemiyolojik hikâyesi, fizik muayene bulgusu ve direkt preparatta Bacillus anthracis görülmesi ile konuldu. Hastanın tedavisi için on gün penisilin verildi. Bu olgu, hastanın gebe olması, ender bir yerleşim olan alt göz kapağına yerleşmesi, anne ve bebekte herhangi bir komplikasyon ve sekele neden olmaması nedeniyle sunulmaya değer bulunmuştur.

show abstract

Anthrax Cases in Pregnant and Postpartum Women

Abstract: Based on these case reports, B anthracis infection in pregnant and postpartum women is associated with high rates of maternal and fetal death. Evidence of possible maternal-fetal transmission of B anthracis infection was identified in early case reports.

Cited by 32 publications

References 18 publications

Prophylaxis and Treatment of Anthrax in Pregnant Women

Prophylaxis and Treatment of Anthrax in Pregnant Women

Cutaneous Anthrax on Eyelid in a Pregnant Woman

Cutaneous Anthrax on Eyelid in a Pregnant Woman

Contact Info

Product

Resources

About