Anthraquinones in Plants: Source, Safety and Applications in Gastrointestinal Health

Demeyer, Kristiaan; Delmulle, Luc; Keukeleire, D. De; Laekeman, Gert; Witte, Peter de

doi:10.7313/upo9781907284823

Cited by 6 publications

(5 citation statements)

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“…Taxonomically, some species have been transferred from Cassia genus to Senna genus [ 15 ]. This taxon currently comprises 500–600 species [ 14 , 16 ], of which many have not been yet characterized with respect to their chemical compositions and biological properties as the arboreal species Senna velutina (Vogel) H. S. Irwin & Barneby (Fabaceae, Caesalpinioideae). In this context, the aim of the present study was to determine the chemical composition of an ethanol extract of S. velutina leaves and to evaluate its antioxidant and antileukemic activities.…”

Section: Introductionmentioning

confidence: 99%

The Chemical Profile of Senna velutina Leaves and Their Antioxidant and Cytotoxic Effects

Campos

Castro

Damião

et al. 2016

Oxidative Medicine and Cellular Longevity

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Natural products can be a source of biomolecules with antioxidant activity which are able to prevent oxidative stress-induced diseases and show antitumor activity, making them important sources of new anticancer drug prototypes. In this context, this study aimed to analyze the chemical composition of an ethanol extract of Senna velutina leaves and to assess its antioxidant and cytotoxic activities in leukemic cells. The antioxidant properties were evaluated using a DPPH free radical scavenging assay and by examining the extract's inhibition of AAPH-induced lipid peroxidation in human erythrocytes. Its cytotoxicity and possible mechanisms of action were assessed in Jurkat and K562 leukemic cell lines. The ethanol extract contained flavonoids, such as epigallocatechin, epicatechin, kaempferol heteroside, rutin, and dimeric and trimeric proanthocyanidin derivatives. The extract exhibited antioxidant activity by scavenging free radicals and antihemolytic action, and it decreased malondialdehyde content in human erythrocytes. Furthermore, the extract also induced leukemic cell death by activating intracellular calcium and caspase-3, decreasing mitochondrial membrane potential, and arresting the cell cycle in S and G2 phases. Hence, S. velutina leaf extract contains antioxidant and antileukemic biomolecules with potential applications in diseases associated with oxidative stress and in the inhibition of tumor cell proliferation.

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Section: Introductionmentioning

confidence: 99%

The Chemical Profile of Senna velutina Leaves and Their Antioxidant and Cytotoxic Effects

Campos

Castro

Damião

et al. 2016

Oxidative Medicine and Cellular Longevity

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“…1,2,4-Triazole derivatives of 9,10-anthraquinone are also not described in the literature. Taking into account the known biological properties of anthraquinone derivatives [38][39][40], it seems appropriate to design hybrid structures containing anthraquinone and thiazole or triazole cycles.…”

Section: Introductionmentioning

confidence: 99%

Computer prediction and synthesis of new azoles based on N-benzoyl-N'-(9,10-dioxo-9,10-dihydroanthracen-1-yl)thioureas

et al. 2014

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New thiazole and 1,2,4-triazole derivatives of 9,10-anthraquinone were obtained by the reaction of N-benzoyl-N'-(9,10dioxo-9,10-dihydroanthracene-1-yl)-thioureas with bromoacetone in the presence of triethylamine and hydrazine hydrate in chloroform, respectively. The PASS computer program was used to predict the biological activity spectra and to determine the most promising biological activities for experimental testing. Thus, it has been shown that the synthesized compounds are a promising class for the creation of substances with a wide range of biological activity.

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“…Many natural derivatives of the 9,10-anthraquinone and drugs based on them are widely used in medicine as an effective medications[ 2 ]. This fact has stimulated a broad search compounds-analogues and study of their pharmacological properties to create new synthetic and semisynthetic biologically active substances.…”

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confidence: 99%

“…Striking examples of such aminoanthraquinones as drugs are ametantron and mitoxantrone. Compounds with antibacterial, antiviral, antiinflammatory[ 4 5 ], purgative and hypoglycemic effects[ 2 ] were identified also among a derivatives of 9,10-anthraquinone. In particular, the emodyn as a derivative of 9,10-anthraquinone, has shown hypoglycemic action, antitumor activity against the lymphocytic leukemia[ 6 ], and cytotoxicity and inhibition of precursor incorporation into DNA and RNA in HL-60 human leukemic cells[ 7 ].…”

mentioning

confidence: 99%

Novel anthraquinone-based derivatives as potent inhibitors for receptor tyrosine kinases

Stasevych¹,

Zvarych²,

Лунин³

et al. 2015

Indian J Pharm Sci

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Anthraquinones in Plants: Source, Safety and Applications in Gastrointestinal Health

Cited by 6 publications

References 0 publications

The Chemical Profile of Senna velutina Leaves and Their Antioxidant and Cytotoxic Effects

The Chemical Profile of Senna velutina Leaves and Their Antioxidant and Cytotoxic Effects

Computer prediction and synthesis of new azoles based on N-benzoyl-N'-(9,10-dioxo-9,10-dihydroanthracen-1-yl)thioureas

Novel anthraquinone-based derivatives as potent inhibitors for receptor tyrosine kinases

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