Anthraquinone, Cyclopentanone, and Naphthoquinone Derivatives from the Sea Fan-Derived Fungi <i>Fusarium</i> spp. PSU-F14 and PSU-F135

Trisuwan, Kongkiat; Khamthong, Nanthaphong; Rukachaisirikul, Vatcharin; Phongpaichit, Souwalak; Preedanon, Sita; Sakayaroj, Jariya

doi:10.1021/np100282k

Cited by 91 publications

(83 citation statements)

References 22 publications

(44 reference statements)

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“…KMM210; la levadura marina Pichia membranifaciens, especies de hongos del género Fusarium spp. PSU-F14 y PSU-F135, y Nigrospora sphaerica (34)(35)(36). Múltiples actividades biológicas se les han atribuido incluyendo antioxidante e inhibidores de citoquinina (37)(38)(39).…”

Section: Discussionunclassified

Búsqueda de bacterias marinas como fuente de inhibidores de quorum sensing (iqs): primer estudio químico de Oceanobacillus profundus (RKHC-62B)

Martínez-Matamoros¹,

FONSECA²,

Duque³

et al. 2016

Vitae

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RESUMENAntecedentes: Los productos naturales aislados de microorganismos marinos han demostrado tener un amplio rango de actividades biológicas incluyendo inhibidores de quorum sensing. Objetivos: Estudiamos quince cepas bacterianas del phylum Firmicutes aisladas del coral blando Antillogorgia elisabethae que fueron evaluadas como una nueva fuente sostenible de compuestos inhibidores de quorum sensing (IQS). Métodos: Se prepararon cultivos en cuatro medios diferentes y extraídos usando una resina no iónica. Todos los extractos fueron probados con el fin de establecer su actividad inhibitoria de quorum sensing (IQS) usando Chromobacterium violaceum ATCC 31532 como biosensor. Los extractos activos fueron fraccionados mediante cartuchos RP-18. Cada fracción fue evaluada mediante bioensayo y analizada por HPLC. Resultados: Las fracciones metanólicas de Jeotgalicoccus halophilus y Oceanobacillus profundus fueron las más activas, lo cual sugiere que los compuestos no polares pueden ser los responsables de esta actividad. Conclusiones: El estudio químico del extracto orgánico de O. profundus cultivado en medio LBS permitió aislar los compuestos tirosol (1) y acetato de tirosol (2) como los responsables de la actividad IQS. Palabras clave: Productos naturales marinos, Microorganismos marinos, Jeotgalicoccus halophilus, Oceanobacillus profundus, Compuestos inhibidores de quorum sensing. ABSTRACTBackground: Natural products isolated from marine microorganisms have demonstrated a wide range of biological activities included quorum sensing inhibitors. Objectives: We study fifteen marine Firmicutes bacterial strains isolated from the Caribbean soft coral Antillogorgia elisabethae that were evaluated as a novel and sustainable source of quorum sensing inhibitor compounds. Methods: Cultures were made in four different culture media and further extracted using a non-ionic resin. All these extracts were tested in order to establish its quorum sensing inhibition (QSI) activity using Chromobacterium violaceum ATCC 31532. The active extracts were fractionated by RP-18 cartridge. Each fraction was tested and evaluated for its composition by HPLC-PDA. Results: Methanol fractions of Jeotgalicoccus halophilus and Oceanobacillus profundus were the most active ones, suggesting that non-polar compounds could be the responsible for the QSI activity of the bacterial extracts here tested. Conclusions: The chemical study

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Section: Discussionunclassified

Búsqueda de bacterias marinas como fuente de inhibidores de quorum sensing (iqs): primer estudio químico de Oceanobacillus profundus (RKHC-62B)

Martínez-Matamoros¹,

FONSECA²,

Duque³

et al. 2016

Vitae

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“…and D-E (from Acremonium sp.) (Chen et al 1996); antimalarial: hypothemycin and aigialomycin D activity at IC50 values of 2.2 and 6.6 μg/ml , while bostrycin showed weak activity (Trisuwan et al 2010); cytotoxic (penochalasins A-C most potent against P388 leukemia cell line (Numata et al 1996;Iwamoto et al 1999), while trichdenones A-C are mildly cytotoxic (Amagata et al 1998), communesins A and B are cytotoxic alkaloids from a Penicillium sp. (Numata et al 1993(Numata et al , 1996, paeciloxocin A against HepG2 cell line (Wen et al 2010), pentostatin A-D, nigrosporanene A against MCF-7 and Vero cells (IC50 values of 9.37, 5.42 μg/mL, respecvtively) (Rukachaisirikul et al 2010); Xylaria psidii and strain KT31 (a sterile algicolous strain from Kappaphycus alvarezii) showed strong cytoxic activity at IC50 values of 4 μg/mL and 1.5 μg/mL, respectively (Tarman et al 2011); platelet activating factor PAF) antagonists: phomactins are a new class pf specific PAF antagonsis (Sugano et al 1995).…”

Section: Bioactive Compoundsmentioning

confidence: 99%

“…Of equal interest are two Fusarium strains isolated from the gorgonian sea fan (Annella sp.) which yielded five new metabolites (a modified anthraquinone fusaranthaquinone, cyclopentanon fusarone, a naphthquinone fusarnaphthoquinone, fusarnaphthoquinone B, furanaphthoquinone C and 18 known compounds (Trisuwan et al 2010). In the search for new sources for bioactive compounds, marine fungi have yielded a wide range of novel compounds both chemical structures and in their pharmacologically activity.…”

Section: Bioactive Compoundsmentioning

confidence: 99%

Fifty years of marine mycology

Jones

2011

Fungal Diversity

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Marine fungi have been widely studied over the past millennium and considerable progress has been made in documenting their phylogeny, biodiversity, ultrastructure, ecology, physiology and their ability to cause decay of lignocellulosic compounds. These studies have generated a wealth of publications and this review will focus primarily on research undertaken since 1995. During this period new topics have attracted marine mycologists especially: algicolous and manglicolous fungi, deep sea fungi, planktonic fungi, endophytes of marine plants, and the screening of taxa for new chemical structures and bioactive compounds. This review will also highlight areas that warrant further investigation, including surveys for marine fungi in Africa, artic waters and south America, more detailed studies of their physiology and biochemistry, and to determine the marine origin of so called "marine derived" fungi.

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“…the anthranoid derivatives 9α-hydroxydihydrodesoxybostrycin, austrocortirubin, fusarubin and anhydrofusarubin, exhibited mild anti-bacterial activity against S. aureus and methicillin-resistant S. aureus (MIC values> 350μM). However, the new compounds showed no activity, except compound 29 which exhibited weak anti-fungal activity against C. neoformans and Microsporum gypseum (MIC values >200μM) (Trisuwan et al 2010). …”

Section: Anti-infective Fungal Metabolitesmentioning

confidence: 88%

Bioactive secondary metabolites from endophytes and associated marine derived fungi

2011

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Endophytes and fungi that are associated with marine invertebrates or with algae are of growing importance as promising sources of structurally unprecedented biologically active natural products. This review covers the literature published in 2010 and highlights new bioactive metabolites and known compounds for which hitherto novel biological activities have been reported. The compounds are grouped according to their reported biological activities which include anti-infective, cytotoxic, antiparasitic, radical scavenging and anti-inflammatory activities. Overall, 106 fungal metabolites, including 87 new natural products, and 53 references are presented.

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Anthraquinone, Cyclopentanone, and Naphthoquinone Derivatives from the Sea Fan-Derived Fungi Fusarium spp. PSU-F14 and PSU-F135

Cited by 91 publications

References 22 publications

Búsqueda de bacterias marinas como fuente de inhibidores de quorum sensing (iqs): primer estudio químico de Oceanobacillus profundus (RKHC-62B)

Búsqueda de bacterias marinas como fuente de inhibidores de quorum sensing (iqs): primer estudio químico de Oceanobacillus profundus (RKHC-62B)

Fifty years of marine mycology

Bioactive secondary metabolites from endophytes and associated marine derived fungi

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