2020
DOI: 10.3389/fmicb.2020.00743
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Anthracycline Shunt Metabolites From Philippine Marine Sediment-Derived Streptomyces Destroy Cell Membrane Integrity of Multidrug-Resistant Staphylococcus aureus

Abstract: The rise of antibiotic resistance (ABR) and the drying up of the pipeline for the development of new antibiotics demands an urgent search for new antibiotic leads. While the majority of clinically available antibiotics were discovered from terrestrial Streptomyces, related species from marine sediments as a source of antibiotics remain underexplored. Here, we utilized culture-dependent isolation of thirty-five marine sediment-derived actinobacterial isolates followed by a screening of their antibacterial activ… Show more

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Cited by 22 publications
(39 citation statements)
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“…These anthracyclines shunt metabolites are precursors of anticancer anthracyclines such as doxorubicin, daunorubicin, and cinerubins. They were accumulated in the growth medium during the fermentation of Streptomyces griseorubens strain DSD069, which is a rare event occurring in a non-genetically modified Streptomyces strain [24]. This recent finding shows that Philippine marine sediment-derived actinomycetes are a potentially rich source of new or novel secondary metabolites.…”
Section: Introductionmentioning
confidence: 88%
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“…These anthracyclines shunt metabolites are precursors of anticancer anthracyclines such as doxorubicin, daunorubicin, and cinerubins. They were accumulated in the growth medium during the fermentation of Streptomyces griseorubens strain DSD069, which is a rare event occurring in a non-genetically modified Streptomyces strain [24]. This recent finding shows that Philippine marine sediment-derived actinomycetes are a potentially rich source of new or novel secondary metabolites.…”
Section: Introductionmentioning
confidence: 88%
“…The sediment samples were air-dried for 8 h in a biosafety hood prior to inoculation in the solid medium of ISP4 (International Streptomyces Project Medium 4) (Difco) with filtered seawater using the dry stamp method (DSM) and heat shock method (HSM) [19,24,46]. The inoculated plates were incubated at room temperature (25 to 28 • C) for 15 to 30 days.…”
Section: Culture-dependent Isolationmentioning
confidence: 99%
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