Anthocyanins-rich interventions on oxidative stress, inflammation and lipid profile in patients undergoing hemodialysis: meta-analysis and meta-regression

Martins, Isabelle Christine Vieira da Silva; Maciel, Michel Garcia; Nascimento, José Luiz Martins do; Mafra, Denise; Santos, Alexsandro F.; Padilha, Camila S.

doi:10.1038/s41430-022-01175-6

Cited by 8 publications

(5 citation statements)

References 67 publications

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“…The antioxidant compounds in pomegranate include anthocyanins and ellagic acid [ 89 , 90 , 91 ], which ameliorate oxidative stress in diabetes. A few studies suggest that anthocyanins, ellagic acid, and PU mediate pomegranate’s anti-oxidative stress effects by degrading and scavenging free radicals [ 42 , 92 , 93 , 94 , 95 , 96 ].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Punica granatum Linn and Its Derivatives on Oxidative Stress, Inflammation, and Endothelial Function in Diabetes Mellitus: Evidence from Preclinical and Clinical Studies

et al. 2023

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Diabetes mellitus is recognized as the leading contributor to cardiovascular disease and associated mortality rates worldwide. Despite the use of pharmaceutical drugs to treat diabetes, its prevalence continues to rise alarmingly. Therefore, exploring remedies with a lower toxicity profile is crucial while remaining safe and effective in addressing this global public health crisis. Punica granatum Linn (pomegranate), known for its properties and safety profile, has been investigated in applied research and preclinical and clinical trials. However, conflicting reports still exist regarding its effects in diabetes. According to our knowledge, no systematic review has been conducted to critically analyze evidence from preclinical and clinical trials simultaneously, explicitly focusing on oxidative stress, inflammation, and endothelial function in diabetes. Therefore, in this systematic review, we searched for evidence on the impact of pomegranate in diabetes using databases such as PubMed, Scopus, and Google Scholar. Our inclusion criteria were limited to studies published in English. Of the 170 retrieved studies, 46 were deemed relevant and underwent critical analysis. The analyzed evidence suggests that pomegranate has the potential to alleviate oxidative stress, inflammation, and endothelial dysfunction in diabetes. Although a beneficial impact was noted in these markers, the endothelial function evidence still requires validation through further clinical trials with a powered sample size.

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Section: Discussionmentioning

confidence: 99%

The Impact of Punica granatum Linn and Its Derivatives on Oxidative Stress, Inflammation, and Endothelial Function in Diabetes Mellitus: Evidence from Preclinical and Clinical Studies

et al. 2023

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“…However, the exact mechanism by which air ltration affects health remains unclear. In ammation and oxidative stress are the key mechanisms in many chronic diseases 33 . Currently, evidence regarding the impact of air ltration on in ammation and oxidative stress is inconsistent 11 .…”

Section: Discussionmentioning

confidence: 99%

The effect of air filtration on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials

Ren

Zhang

et al. 2023

Preprint

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BACKGROUND Improvement of indoor air quality is beneficial for human health. However, previous studies have not reached consistent conclusions regarding the effects of indoor air filtration on inflammation and oxidative stress. OBJECTIVE This study aims to determine the relationship between indoor air filtration and inflammation and oxidative stress biomarkers. METHODS We conducted an electronic search that evaluated the association of indoor air filtration with biomarkers of inflammation and oxidative stress in five databases (PubMed, Cochrane Library, EMBASE, Web of Science, and Scopus) from the beginning to April 23, 2022. Outcomes included the following markers: interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), malondialdehyde (MDA), 8-hydroxy-2deoxyguanosine (8-OHdG), and 8-iso-prostaglandinF2α (8-isoPGF2α). We extracted data from the included studies according to the system evaluation and the preferred reporting item for meta-analysis (PRISMA) guidelines and used the Cochrane risk of bias tool to assess bias risk. RESULTS Our meta-analysis included 15 studies with 678 participants to assess the combined effect size. The meta-analysis demonstrated that indoor air filtration could have a marked reduction in IL-6 (SMD: -0.275, 95% CI: − 0.545 to − 0.005, p = 0.046) but had no significant effect on other markers of inflammation or oxidative stress. Subgroup analysis results demonstrated a significant reduction in 8-OHdG levels in the subgroup with < 1 day of duration (SMD: − 0.916, 95% CI: − 1.513 to − 0.320; p = 0.003) and using filtrete air filter (SMD: − 5.530, 95% CI: − 5.962 to − 5.099; p < 0.001). CONCLUSION Our meta-analysis results depicted that indoor air filtration can significantly reduce levels of inflammation and oxidative stress markers. Considering the adverse effects of air pollution on human health, our study provides powerful evidence for applying air filtration to heavy atmospheric pollution.

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“…Compared to flavan-3-ols, clinical research on other (poly)phenols currently is not as extensive but still, there is an increasing number of meta-analyses of RCTs available for most (poly)phenol subclasses. Several meta-analyses have collectively suggested that anthocyanins and anthocyanin-rich foods are able to improve BP, TC, TG, LDL-C, HDL-C, fasting glucose, HbA1c, FMD and pulse-wave velocity (32)(33)(34)(35)(36)(37) . Our group have shown that berry anthocyanins can improve endothelial function in a dose-dependent manner, both as purified anthocyanins and as part of whole berries (38,39) .…”

Section: Effects Of (Poly)phenols On Cardiometabolic Health: Clinical...mentioning

confidence: 99%

Dietary (poly)phenols and cardiometabolic health: from antioxidants to modulators of the gut microbiota

Rodriguez-Mateos,

Le Sayec,

Cheok

2024

Proc. Nutr. Soc.

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(Poly)phenols are plant secondary metabolites widely abundant in plant foods and beverages comprising a very large number of compounds with diverse structure and biological activities. Accumulating evidence indicates that these compounds exert beneficial effects against cardiometabolic diseases, and this review will provide a summary of current knowledge in this area. Epidemiological and clinical data collectively suggest that intake of flavonoids reduces the risk of cardiovascular disease (CVD), with the evidence being particularly strong for the flavan-3-ol subclass. However, to provide adequate dietary recommendations, a better understanding of their estimated content in foods and intake among the general public is needed. Regarding mechanisms of action, we now know that it is unlikely that (poly)phenols act as direct antioxidants in vivo, as it was hypothesised for decades with the popularity of in vitro antioxidant capacity assays. One of the reasons is that upon ingestion, (poly)phenols are extensively metabolised into a wide array of circulating metabolites with different bioactivities than their precursors. Well-conducted in vitro and in vivo studies and human nutrigenomic analysis have revealed new molecular targets that may be underlying the health benefits of (poly)phenols, such as the nitric oxide pathway. Recently, a bi-directional relationship was established between (poly)phenols and the gut microbiota, suggesting that individual gut microbial metabolising capacity may be a key factor explaining the variability in the cardiometabolic response to (poly)phenols. Future research is needed to elucidate which are the key factors affecting such capacity, and whether it can be modulated, along with the mechanisms of action.

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Anthocyanins-rich interventions on oxidative stress, inflammation and lipid profile in patients undergoing hemodialysis: meta-analysis and meta-regression

Cited by 8 publications

References 67 publications

The Impact of Punica granatum Linn and Its Derivatives on Oxidative Stress, Inflammation, and Endothelial Function in Diabetes Mellitus: Evidence from Preclinical and Clinical Studies

The Impact of Punica granatum Linn and Its Derivatives on Oxidative Stress, Inflammation, and Endothelial Function in Diabetes Mellitus: Evidence from Preclinical and Clinical Studies

The effect of air filtration on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials

Dietary (poly)phenols and cardiometabolic health: from antioxidants to modulators of the gut microbiota

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