Anthocyanins: Promising Natural Products with Diverse Pharmacological Activities

Liu, Jiaqi; Zhou, Hua-Fu; Song, Li; Yang, Zhenhua; Qu, Min; Wang, Jia; Shi, Songli

doi:10.3390/molecules26133807

Cited by 94 publications

(66 citation statements)

References 134 publications

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“…ACNs are well documented for their antioxidant, antiinflammatory, and anti-apoptotic effects on human health (Henriques et al, 2020;Kozłowska and Dzierżanowski, 2021;Liu et al, 2021;Pérez-Torres et al, 2021;Vega-Galvez et al, 2021). ACNs could be rapidly absorbed in the stomach and detected in the blood and urine (Fang, 2014;Tian et al, 2019), so these pigments are recognized as one of the leading nutraceuticals for prolonging health benefits through the attenuation of chronic, non-communicable diseases, including cancers, obesity, diabetes, cardiovascular diseases, and neurodegenerative diseases.…”

Section: Anthocyanins and Their Biological Effects On Chronic Diseasesmentioning

confidence: 99%

Research Progress of the Role of Anthocyanins on Bone Regeneration

et al. 2021

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Bone regeneration in osteoporosis and fragility fractures which are highly associated with age remains a great challenge in the orthopedic field, even though the bone is subjected to a continuous process of remodeling which persists throughout lifelong. Regulation of osteoblast and osteoclast differentiation is recognized as effective therapeutic targets to accelerate bone regeneration in osteopenic conditions. Anthocyanins (ACNs), a class of naturally occurring compounds obtained from colored plants, have received increasing attention recently because of their well-documented biological effects, such as antioxidant, anti-inflammation, and anti-apoptosis in chronic diseases, like osteoporosis. Here, we summarized the detailed research progress on ACNs on bone regeneration and their molecular mechanisms on promoting osteoblast differentiation as well as inhibiting osteoclast formation and differentiation to explore their promising therapeutic application in repressing bone loss and helping fragility fracture healing. Better understanding the role and mechanisms of ACNs on bone regeneration is helpful for the prevention or treatment of osteoporosis and also for the exploration of new bone regenerative medicine.

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Section: Anthocyanins and Their Biological Effects On Chronic Diseasesmentioning

confidence: 99%

Research Progress of the Role of Anthocyanins on Bone Regeneration

et al. 2021

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“…Several studies have suggested that treatment with protective compounds that inhibit oxidative stress and inflammation could reduce the amount of photoreceptor cell death in animal models of light-induced retinal damage (LD) [ 8 , 9 , 10 ]. In particular, exogenous compounds belonging to carotenoid or anthocyanin families, such as lutein and cyanidin-3-glucoside (C3G), have been recognized among the most promising substances capable to prevent/counteract oxidative stress through a direct free radical scavenging effect [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Additional efficacy of C3G depends on its capability to stimulate rhodopsin regeneration in the outer retina [ 20 ]. In response to oxidative stress, the antioxidant and anti-inflammatory properties of lutein or C3G result in improved retinal function presumably through reduced photoreceptor death [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary Supplementation of Antioxidant Compounds Prevents Light-Induced Retinal Damage in a Rat Model

et al. 2021

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Light-induced retinal damage (LD) is characterized by the accumulation of reactive oxygen species leading to oxidative stress and photoreceptor cell death. The use of natural antioxidants has emerged as promising approach for the prevention of LD. Among them, lutein and cyanidin-3-glucoside (C3G) have been shown to be particularly effective due to their antioxidant and anti-inflammatory activity. However, less is known about the possible efficacy of combining them in a multicomponent mixture. In a rat model of LD, Western blot analysis, immunohistochemistry and electroretinography were used to demonstrate that lutein and C3G in combination or in a multicomponent mixture can prevent oxidative stress, inflammation, gliotic and apoptotic responses thus protecting photoreceptor cells from death with higher efficacy than each component alone. Combined efficacy on dysfunctional electroretinogram was also demonstrated by ameliorated rod and cone photoreceptor responses. These findings suggest the rationale to formulate multicomponent blends which may optimize the partnering compounds bioactivity and bioavailability.

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“…Moreover, anthocyanins, cyanidin, and their derivatives possess cardioprotective activity due to their antioxidant, anti-inflammatory actions, and inhibiting endothelial dysfunction and NO production. 56 Chlorogenic acid and quercetin- O -glucoside also had a cardioprotective, 57,58 and anti-depressant actions. 59,60 …”

Section: Resultsmentioning

confidence: 99%