Anthocyanins from the seed coat of black soybean reduce retinal degeneration induced by N-methyl-N-nitrosourea

Paik, Sun-Sook; Jeong, Eojin; Jung, Sung Won; Ha, Tae Joung; Kang, Seungbum; Sim, Sooyeon; Jeon, Ji Hyun; Chun, Myung-Hoon; Kim, In‐Beom

doi:10.1016/j.exer.2012.02.010

Cited by 52 publications

(37 citation statements)

References 42 publications

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“…Blackcurrant anthocyanin supplementation (50 mg/day) for 24 months increased ocular blood flow in 19 patients with open-angle glaucoma, however, there were no significant changes in the intraocular pressure [95]. Supplementation of anthocyanins (50 mg/kg body weight) from the seed coat of black soybean to N-methyl-N-nitrosourea-induced retinal degenerative rats also prevents retinal degeneration [94], and also suppresses human lens epithelial cell death under hydrogen peroxide-induced oxidative stress by 50–200 μg/ml of the extract [93]. Anthocyanin also predominates around 70% in purple corn seed [124], where purple corn seed extract decreases lens opacity together with lower malonaldehyde levels [92].…”

Section: Nutraceutical and Pharmaceutical Effects Of Anthocyaninsmentioning

confidence: 99%

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

Khoo

Azlan

Tang

et al. 2017

Food & Nutrition Research

1,930

1,327

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Anthocyanins are colored water-soluble pigments belonging to the phenolic group. The pigments are in glycosylated forms. Anthocyanins responsible for the colors, red, purple, and blue, are in fruits and vegetables. Berries, currants, grapes, and some tropical fruits have high anthocyanins content. Red to purplish blue-colored leafy vegetables, grains, roots, and tubers are the edible vegetables that contain a high level of anthocyanins. Among the anthocyanin pigments, cyanidin-3-glucoside is the major anthocyanin found in most of the plants. The colored anthocyanin pigments have been traditionally used as a natural food colorant. The color and stability of these pigments are influenced by pH, light, temperature, and structure. In acidic condition, anthocyanins appear as red but turn blue when the pH increases. Chromatography has been largely applied in extraction, separation, and quantification of anthocyanins. Besides the use of anthocyanidins and anthocyanins as natural dyes, these colored pigments are potential pharmaceutical ingredients that give various beneficial health effects. Scientific studies, such as cell culture studies, animal models, and human clinical trials, show that anthocyanidins and anthocyanins possess antioxidative and antimicrobial activities, improve visual and neurological health, and protect against various non-communicable diseases. These studies confer the health effects of anthocyanidins and anthocyanins, which are due to their potent antioxidant properties. Different mechanisms and pathways are involved in the protective effects, including free-radical scavenging pathway, cyclooxygenase pathway, mitogen-activated protein kinase pathway, and inflammatory cytokines signaling. Therefore, this review focuses on the role of anthocyanidins and anthocyanins as natural food colorants and their nutraceutical properties for health. Abbreviations: CVD: Cardiovascular disease VEGF: Vascular endothelial growth factor

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Section: Nutraceutical and Pharmaceutical Effects Of Anthocyaninsmentioning

confidence: 99%

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

Khoo

Azlan

Tang

et al. 2017

Food & Nutrition Research

1,930

1,327

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“…It should be noted, that even if Raman spectroscopy can be used in surface-sensitive mode (surface-enhanced Raman spectroscopy), [3] its main drawback is the indirect information, which is not easy to quantify in terms of sp 2 /sp 3 . In fact, both carbon bands named D and G, measurable in visible Raman spectroscopy, [4][5][6][7][8][9] are attributed to trigonal bonding: the G-band is a direct signal of sp 2 bonds, whereas the D-band is originating from the bond angle disorder in the sp 2 microdomains, which is induced by linking with the atoms in sp 3 configuration. [4,5] NEXAFS and HEELS are often considered as the most reliable techniques for the measurements of carbon hybridization.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopy of carbon: from diamond to nitride films

Kačiulis

2012

Surface & Interface Analysis

175

166

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Every surface scientist knows about the importance of carbon spectroscopy: the signals of C 1 s and C KLL usually are indicating the surface cleanness, whereas C 1 s peak is often used as a reference for the calibration of energy scale. Carbon spectroscopy becomes even more important in the case of the studies dedicated to new carbon-based materials, such as nanotubes, graphene, diamond-like carbon (DLC), carbon nitride, carbides, etc. It is well-known that the carbon atoms can be arranged in a great variety of crystalline and disordered structures, because their electrons can hybridize in sp 3 , sp 2 and even in linear sp configurations. Namely, the hybridization of carbon electrons defines the mechanical, electrical and optical properties of these materials. Indeed, between the pure diamond (sp 3 ) and graphite (sp 2 ), there are many phases of amorphous material characterized by different sp 2 /sp 3 ratios and generally named DLC. Electron spectroscopies (X-ray photoelectron spectroscopy, Auger electron spectroscopy and electron energy loss spectroscopy) are widely recognized as analytical techniques, able to identify the bonds of diamond, graphite and amorphous phases of carbon. The binding energy of C 1 s spectrum together with its plasmon losses, the shape of Auger peak and valence band spectra can be used to characterize the structure of carbon-based materials. In this study, an overview is reported on carbon spectroscopy, comparing different experimental methods. Their application for the characterization of DLC and carbon nitride films, including the determination of carbon's sp 2 /sp 3 ratio is discussed and illustrated by experimental results obtained for a series of thin films of these materials.

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“…Since MNU injection specifically induces apoptosis of retinal cells within several days in animals [30], MNU-induced retinal damage is a good model for RP. Using this model of retinal degeneration, previous studies have demonstrated retinoprotective effects of the apoptosis inhibitor 3-aminobenzamide [30], calcium antagonists nimodipine [36] and docosahexaenoic acid [37], anthocyanins extracted from black soy beans [38], nicotinamide [39], and curcumin [40]. In search of the remedy for RP, very low toxicity is a key requirement for compounds aimed at preventing retinopathy, since retinal damage in RP patients develops through a gradual process that progresses over decades.…”

Section: Discussionmentioning

confidence: 99%

Suppression of <i>N</i>-Methyl-<i>N</i>-Nitrosourea-Induced Retinal Damage in Mice by Oligonol, an Oligomerized Polyphenol Formulation

Kisugi¹,

Nasui²,

Wakame³

et al. 2014

ABC

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Oligonol is a lychee fruit-derived functional food that contains oligomerized polyphenol compounds. Oligonol exhibits a number of beneficial biological effects, primarily due to its antioxidant activity. Retinitis pigmentosa (RP) is an inherited chronic degenerative disease affecting retinal photoreceptor cells. There is currently no effective therapy capable of stopping or reversing the progression of the disease. In RP, apoptosis of photoreceptor cells resulting from oxidative damage is considered to be the final common pathway. In this report, we present an evaluation of the suppressive activity of Oligonol against N-methyl-N-nitrosourea (

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Anthocyanins from the seed coat of black soybean reduce retinal degeneration induced by N-methyl-N-nitrosourea

Cited by 52 publications

References 42 publications

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

Spectroscopy of carbon: from diamond to nitride films

Suppression of <i>N</i>-Methyl-<i>N</i>-Nitrosourea-Induced Retinal Damage in Mice by Oligonol, an Oligomerized Polyphenol Formulation

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Anthocyanins from the seed coat of black soybean reduce retinal degeneration induced by N-methyl-N-nitrosourea

Cited by 52 publications

References 42 publications

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

Spectroscopy of carbon: from diamond to nitride films

Suppression of &lt;i&gt;N&lt;/i&gt;-Methyl-&lt;i&gt;N&lt;/i&gt;-Nitrosourea-Induced Retinal Damage in Mice by Oligonol, an Oligomerized Polyphenol Formulation

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Suppression of <i>N</i>-Methyl-<i>N</i>-Nitrosourea-Induced Retinal Damage in Mice by Oligonol, an Oligomerized Polyphenol Formulation