Anthocyanins and Flavonols: Therapeutic Implications of Natural Compounds on Cancer

Assmann, Charles Elias; Weis, Grazielle Castagna Cezimbra; Rosa, Jéssica Righi da; Bonadiman, Beatriz da Silva Rosa; Alves, Audrei de Oliveira; Borsoi, Felipe Tecchio; Bagatini, Margarete Dulce

doi:10.1007/978-981-15-9411-3_139

Cited by 1 publication

(1 citation statement)

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“…Quercetin can regulate the expression of E-cadherin, NF-κB, p65, anti-TLR4, cannabinoid receptor CB1-R, and EMT markers (E-catenin, Ncatenin, Wnt/β-catenin, and Snail). Current studies on the effects of quercetin in colorectal cancer indicate that this flavonoid can inhibit the cell viability of CT26 and MC38 cancer cells and induce apoptosis via MAPK pathways [36]. Similarly, studies have concluded that 8-C-(E-phenylethenyl) quercetin, a quercetin derivative, triggers G2 phase arrest in colorectal cancer cells and inhibits proliferation.…”

Section: Phenolic Acids and Flavonoidsmentioning

confidence: 99%

Mechanisms of Action of Fruit and Vegetable Phytochemicals in Colorectal Cancer Prevention

Alzate-Yepes,

Pérez-Palacio,

Martínez

et al. 2023

Molecules

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Colorectal cancer (CRC) is the third most common cancer worldwide and its incidence is expected to increase by almost 80% by 2030. CRC apparition is related to poor diet, mainly due to low consumption of phytochemicals present in fruits and vegetables. Hence, this paper reviews the most promising phytochemicals in the literature, presenting scientific evidence regarding potential CRC chemopreventive effects. Moreover, this paper reveals the structure and action of CRC mechanisms that these phytochemicals are involved in. The review reveals that vegetables rich in phytochemicals such as carrots and green leafy vegetables, as well as some fruits such as pineapple, citrus fruits, papaya, mango, and Cape gooseberry, that have antioxidant, anti-inflammatory, and chemopreventive properties can promote a healthy colonic environment. Fruits and vegetables in the daily diet promote antitumor mechanisms by regulating cell signaling and/or proliferation pathways. Hence, daily consumption of these plant products is recommended to reduce the risk of CRC.

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Section: Phenolic Acids and Flavonoidsmentioning

confidence: 99%