Anthocyanin‐rich extracts suppress the DNA‐damaging effects of topoisomerase poisons in human colon cancer cells

Esselen, Melanie; Fritz, Jessica; Hutter, Melanie; Teller, Nicole; Baechler, Simone A.; Boettler, Ute; Marczylo, Tim; Gescher, Andreas J.; Marko, Doris

doi:10.1002/mnfr.201000315

Cited by 31 publications

(21 citation statements)

References 41 publications

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“…Anthocyanins were also able to inhibit cell growth and are an inducer of cell apoptosis in colon cancer cells by modulating DNA damage [22][23][24] , inducing a cell cycle arrest [12,25] or are responsible for demethylation of tumour suppressor genes [26] .…”

Section: Discussionmentioning

confidence: 99%

Anthocyanins Prevent Colorectal Cancer Development in a Mouse Model

et al. 2017

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BACKGROUND Colorectal cancer is the main leading cause of cancer-related deaths worldwide. Present data suggest that plant-derived anthocyanins have anti-inflammatory and chemopreventive properties. This study was aimed at evaluating the effect of an anthocyanin-rich extract from bilberries on colorectal tumour development and growth in the administration of azoxymethan (AOM)/dextran sodium sulfate (DSS) mouse model. METHODS Colonic carcinogenesis was induced by AOM and DSS 3 or 5%, respectively, in 50 female Balb/c mice. Mice received either normal food (controls) or a diet containing either 10 or 1% anthocyanin-rich bilberry extract. Colonoscopy took place at week 4 and 9 after initiation of carcinogenesis. After termination at week 9, colon samples were analysed macroscopically and microscopically. RESULTS Mice receiving 10% anthocyanins showed significantly (p < 0.004) less reduced colon length (12.1 cm [8.5-14.4 cm]) as compared to controls (11.2 cm [9.8-12.3]) indicating less inflammation. Mice fed with 10% anthocyanin-rich extract revealed significantly less mean tumour numbers (n = 1.2) compared to control (n = 14) and anthocyanin 1% treated mice (n = 10.6, p < 0.001). CONCLUSION Anthocyanins prevented the formation and growth of colorectal cancer in AOM/DSStreated Balb/c mice. Further studies should investigate the mechanisms of how anthocyanins influence the development of colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

Anthocyanins Prevent Colorectal Cancer Development in a Mouse Model

et al. 2017

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“…Anthocyanins are a type of flavonoids which possesses Antioxidant and antimicrobial activity. Anthocyanins are good for neural disorders and it can also neutralise the toxins which can impair the normal cells during chemotherapeutic treatment of cancer [6] [7] . Black Carrot can be considered as a good candidate for producing red/pink/purple food colours as a better and acceptable alternative instead of carmine from Arthropods.…”

Section: Daucuscarota Ssp Sativus (Black Carrot)mentioning

confidence: 99%

Study of Daucus carota ssp. Sativus and Butea monosperma to analyse their Applicability in Pharmaceutical Industry as Antimicrobial Agents

Bhalla

Kumar²,

Shukla

2018

ijpm

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Human Beings have been using plant products to heal the Wounds and Diseases from the inception of humankind. Even when it was not known that microorganisms exist, People have been using antimicrobial agents prepared from plants. These antimicrobial products were prepared by extracting the plant in a suitable solvent. Antimicrobial property is conferred to plants by the presence of various phytochemicals which are the products of several Secondary metabolic pathways. The aim of this project was to decipher the potential use of Daucus carota ssp. Sativus and Butea monosperma in the pharmaceutical industry. In this research, Qualitative phytochemical screening and antimicrobial potential of Black carrot and Kamarkas has been studied.Black carrot showed good antimicrobial activity against A. brasiliensis, E. coli and S. enterica, arranged in descending order of the Slope obtained in each antimicrobial assay. Phytochemical screening showed the presence of Flavonoids, Soluble Phenolic Compounds, Naphthoquinone and traces of Saponins and Alkaloids. The Kamarkas showed antimicrobial activity against S. aureus and to some extent against A. brasiliensis. Phytochemical analysis of Kamarkas showed positive for all phytochemicals.

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“…Treatment of human monocytic THP-1 cells with bilberry extract showed reduction in pro-inflammatory gene expression, interferon γ (IFN-γ), and cytokine secretion [125]. Moreover, bilberry extract exerts the ability to induce apoptosis and arrest growth in GI cancer ( Figure 2) [126]. Bilberry extract has been reported to diminish topoisomerase catalytic activity in colon carcinoma cells, showing a protective DNA effect [127].…”

Section: Ellagic Acidmentioning

confidence: 99%

Phytochemicals and Gastrointestinal Cancer: Cellular Mechanisms and Effects to Change Cancer Progression

2020

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Gastrointestinal (GI) cancer is a prevailing global health disease with a high incidence rate which varies by region. It is a huge economic burden on health care providers. GI cancer affects different organs in the body such as the gastric organs, colon, esophagus, intestine, and pancreas. Internal and external factors like smoking, obesity, urbanization, genetic mutations, and prevalence of Helicobacter pylori and Hepatitis B and Hepatitis C viral infections could increase the risk of GI cancer. Phytochemicals are non-nutritive bioactive secondary compounds abundantly found in fruits, grains, and vegetables. Consumption of phytochemicals may protect against chronic diseases like cardiovascular disease, neurodegenerative disease, and cancer. Multiple studies have assessed the chemoprotective effect of selected phytochemicals in GI cancer, offering support to their potential towards reducing the pathogenesis of the disease. The aim of this review was to summarize the current knowledge addressing the anti-cancerous effects of selected dietary phytochemicals on GI cancer and their molecular activities on selected mechanisms, i.e., nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), detoxification enzymes, adenosine monophosphate activated protein kinase (AMPK), wingless-related integration site/β-catenin (wingless-related integration site (Wnt) β-catenin, cell apoptosis, phosphoinositide 3-kinases (PI3K)/ protein kinase B AKT/ mammalian target of rapamycin (mTOR), and mitogen-activated protein kinase (MAPK). In this review phytochemicals were classified into four main categories: (i) carotenoids, including lutein, lycopene, and β-carotene; (ii) proanthocyanidins, including quercetin and ellagic acid; (iii) organosulfur compounds, including allicin, allyl propyl disulphide, asparagusic acid, and sulforaphane; and (iv) other phytochemicals including pectin, curcumins, p-coumaric acid and ferulic acid. Overall, phytochemicals improve cancer prognosis through the downregulation of β-catenin phosphorylation, therefore enhancing apoptosis, and upregulation of the AMPK pathway, which supports cellular homeostasis. Nevertheless, more studies are needed to provide a better understanding of the mechanism of cancer treatment using phytochemicals and possible side effects associated with this approach.

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Anthocyanin‐rich extracts suppress the DNA‐damaging effects of topoisomerase poisons in human colon cancer cells

Abstract: These results raise the possibility that high intake of berry extracts may protect DNA and thus counteract the therapeutic effectiveness of orally applied topoisomerase poisons during chemotherapy.

Cited by 31 publications

References 41 publications

Anthocyanins Prevent Colorectal Cancer Development in a Mouse Model

Anthocyanins Prevent Colorectal Cancer Development in a Mouse Model

Study of <em>Daucus carota ssp. Sativus</em> and <em>Butea monosperma</em> to analyse their Applicability in Pharmaceutical Industry as Antimicrobial Agents

Phytochemicals and Gastrointestinal Cancer: Cellular Mechanisms and Effects to Change Cancer Progression

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