Anthocyanin pharmacokinetics and dose-dependent plasma antioxidant pharmacodynamics following whole tart cherry intake in healthy humans

Seymour, Eric; Warber, Sara M.; Kirakosyan, Ara; Noon, Kathleen R.; Gillespie, Brenda W.; Uhley, Virginia; Wunder, Jenna; Urcuyo, Daniel E.; Kaufman, Peter B.; Bolling, Steven F.

doi:10.1016/j.jff.2014.08.007

Cited by 33 publications

(20 citation statements)

References 26 publications

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“…The most recent papers published on the subject are summarized in Table 2 [96,101,[140][141][142][143][144][145][146][147][148][149][150][151]. Anthocyanins are metabolized to a structurally diverse range of metabolites that exhibit dynamic kinetic profiles.…”

Section: Flavonoids -From Biosynthesis To Human Health 212mentioning

confidence: 99%

“…Pharmacokinetic trial to evaluate the bioavailability of anthocyanins and colonic polyphenol metabolites after consumption of aronia berry extract in plasma and urine [96] Evaluation of the protective effects of protocatechuic acid [140] Effects of black raspberry extract and protocatechuic acid on DNA adduct formation and mutagenesis in rat oral fibroblasts [141] Influence of ethanol on the bioavailability and pharmacokinetics of blackberry anthocyanins [142] Pharmacokinetic trial to evaluate the of nanoencapsulation of a phenol extract from grape pomace on human plasma [143] Pharmacokinetic characterization of anthocyanins in overweight adults on the basis of meal timing [97] Determination of cyanidin 3-glucoside in rat brain, liver and kidneys: a short-term pharmacokinetic study [144] Pharmacokinetics, bioavailability and regional brain distribution of polyphenols from apple-grape seed extract mixture and bilberry extract [145] Evaluation of changes in metabolic parameters, and in cardiovascular and liver structure and function in rat due to administration of either cyanidin 3-glucoside or Queen Garnet plum juice [146] Bioavailability and uptake of anthocyanins and their metabolites from an anthocyanins-rich grape/ blueberry juice and smoothie in vivo and in vitro [101] Effects of anthocyanins and their corresponding anthocyanidins on the expression levels of organic anion transporting polypeptides in primary human hepatocytes [147] Effect of flavan-3-ols and anthocyanins against inflammatory-related diseases [148] Anthocyanin pharmacokinetics and dose-dependent plasma antioxidant pharmacodynamics by intake of Montmorency tart cherries in healthy humans [149] Pharmacokinetics of the metabolites of cyanidin-3-glucoside [150] Abundance and persistence of metabolites of anthocyanins in human urine [151] …”

Section: Comments Referencesmentioning

confidence: 99%

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Antioxidant Capacity of Anthocyanin Pigments

Martín¹,

Kuskoski²,

Navas³

et al. 2017

Flavonoids - From Biosynthesis to Human Health

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Anthocyanins are a family of natural pigments classified into the group of flavonoids, considered to be responsible for the color and taste of many fruits and vegetables, i.e. berries. Anthocyanins are common components of the human diet. Besides their interest as colorant because of their coloring properties, the study of anthocyanin compounds stems from their wide applicability in the prevention and even in the treatment of various human diseases. However, various aspects of the pharmacological roles of anthocyanins remain in the dark, having still several obstacles to the development of robust diets or prescribing lines on consumption of anthocyanins. The chemical structure of anthocyanins determines in large measure its capacity and efficacy as an antioxidant agent. In this study, the following aspects are reviewed: the antioxidant effect of anthocyanin pigments; the oxidative stress, the bioavailability after intake and biological aspects of anthocyanins, the method for measuring the antioxidant activity of anthocyanins, the relationship between structure and activity; and the influence of the anthocyanins in the antioxidant activity of wines. Finally an overview of some potential uses in food industry is attempted mainly focusing in the anthocyanin encapsulation topic. Attention has been paid to the more recent publications in the field.

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Section: Flavonoids -From Biosynthesis To Human Health 212mentioning

confidence: 99%

Section: Comments Referencesmentioning

confidence: 99%

Antioxidant Capacity of Anthocyanin Pigments

Martín¹,

Kuskoski²,

Navas³

et al. 2017

Flavonoids - From Biosynthesis to Human Health

View full text Add to dashboard Cite

show abstract

“…An acknowledged limitation of the current study is that the analysis was not exhaustive, and so not every intake [14,19]. As a result, the timeframe of the analysis in the current study may be regarded as a potential 346 limitation.…”

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confidence: 95%

Phytochemical uptake following human consumption of Montmorency tart cherry (L. Prunus cerasus) and influence of phenolic acids on vascular smooth muscle cells in vitro

et al. 2015

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“…An investigation on the bioavailability of anthocyanins observed an association between colon microbiota metabolism of anthocyanins and a significant increase in the content of generated polyphenols in the brain. There is a possibility that the peak levels observed at 6h is as a result of re-uptake of polyphenols in the colon [58,59]. For this reason, repeat cognitive tasks were administered 6 h post consumption of the plum juice for our study.…”

mentioning

confidence: 99%