Anthocyanin oligomer (grape skin extract) administration improves dry eye disease: A randomised, double‐blind, placebo‐controlled study

Abstract

Background Dry eye disease is a chronic, progressive ocular disease characterised by ocular discomfort and is one of the most common ophthalmological disorders that affects people's lives. Methods This study investigated the clinical efficacy of anthocyanin oligomers (grape skin extract) for the treatment of dry eye. One hundred and eight patients with dry eye were randomly divided into placebo and treatment groups, each with 54 cases. The placebo group received maltodextrin (800 mg/day) and the treatment group received anthocyanin oligomers (800 mg/day). Clinical efficacy, clinical indices, and occurrence of adverse reactions were compared between the two groups. Results Anthocyanin oligomers were safe and effective in mild‐to‐moderate dry eye disease, improving the tear break‐up time, intraocular pressure, ocular surface disease, and patient symptomatology. Conclusions The use of oral anthocyanin oligomers in the treatment of dry eye patients can enhance the therapeutic effect and improve the quality of life of patients while ensuring the safety of treatment, making this therapeutic option suitable for wider application.

Anthocyanin Oligomers Induce Apoptosis and Autophagy by Inhibiting the mTOR Signaling Pathway in Human Breast Cancer Cells

“…According to a previous study, an AO produced by the Aspergillus niger -based fermentation of grape skin extract was more biologically active than the monomeric anthocyanin ( Figure 1 A) [ 7 ]. Furthermore, it has been reported that the antioxidant activity of this AO mixture improved symptoms in a mouse model of dry eye disease and promoted the browning of white adipocytes by increasing fat metabolism [ 8 , 9 , 10 ]. However, though much research has been conducted on the anti-cancer effects of plant-sourced AOs, comparatively little is known about the anti-cancer effects of AOs synthesized by fermentation.…”