Anthocephalus cadamba (Roxb.) Miq., Rubiaceae, extract shows hypoglycemic effect and eases oxidative stress in alloxan-induced diabetic rats

Alam, Muhammad Ashraful; Subhan, Nusrat; Chowdhury, Sadia Afreen; Awal, Mohammad Abdul; Mostofa, M; Rashid, Mohammad A.; Hasan, Choudhury M.; Nahar, Lutfun; Sarker, Satyajit D.

doi:10.1590/s0102-695x2011005000033

Cited by 17 publications

(9 citation statements)

References 48 publications

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“…All drugs were diluted with saline (0.9%) in established doses and administered orally by gavage in a volume of 0.5 ml/100 g body weight (Trovato et al, 1996;Diehl et al, 2001). Glucose levels were measured before the rats received the treatment (zero time) and 30 min after glucose was administrated (4 g/kg) (Alam et al, 2011;Pereira et al, 2012). Blood samples were collected from the tail vein just prior to and 30, 60 and 180 min after glucose loading, and the glucose level (mg/dl) was assayed by a glucometer (Accu-Chek ® Performa).…”

Section: Oral Glucose Tolerance Curvementioning

confidence: 99%

Hypoglycemic and hypolipidemic effects of Solidago chilensis in rats

Schneider

Sachett

Schönell

et al. 2015

Revista Brasileira de Farmacognosia

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a b s t r a c tSolidago chilensis Meyen, Asteraceae, is traditionally used to treat inflammation. However, phytochemical and pharmacology investigations are lacking. This study evaluated the hypoglycemic and hypolipidemic effects of hydroalcoholic extract from S. chilensis aerial parts in rats. In oral glucose tolerance tests the rats received saline (0.5 ml/100 g) in control group (C), hydroalcoholic extract (125, 250 or 500 mg/kg p.o.; n = 6) or glibenclamide (10 mg/kg p.o.; n = 6). After 30 min, glucose (4 g/kg) was administered. Rats treated with hydroalcoholic extract 500 demonstrated decreased glucose levels at 180 min (−22.1%), when compared with group C, similar to glibenclamide. Moreover, treatment with hydroalcoholic extract 500 significantly increased the glycogen content in the liver and soleus muscle, and hydroalcoholic extract 250 specifically inhibited the enzyme maltase when compared with group C. Furthermore, all hyperglycemic rats treated with hydroalcoholic extract (125, 250 and 500) exhibited an accentuated decrease in total cholesterol levels (−36.8%, −36.7% and −41.3%, respectively). Our results suggest that hypoglycemic and hypolipidemic effects of hydroalcoholic extract could be associated with increased production and release of insulin as well as with insulinotropic and antioxidant effects.

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Section: Oral Glucose Tolerance Curvementioning

confidence: 99%

Hypoglycemic and hypolipidemic effects of Solidago chilensis in rats

Schneider

Sachett

Schönell

et al. 2015

Revista Brasileira de Farmacognosia

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“…The dynamic regulation of liver glucose metabolism is vital for systemic carbohydrate homeostasis, and the disorder of insulin secretion could lead to diabetes. Previous studies have reported that various extracts of N.cadamba can reduce the blood glucose level of hyperglycemic mice by increasing the glucose uptake [1,2,5,29]. Based on our bioinformatics prediction, PI3K/Akt pathway were targeted by N.cadamba miRNAs.…”

Section: Discussionmentioning

confidence: 83%

Exploration of miRNAs in Neolamarckia cadamba and their potential cross-kingdom functions

Rui

Chen

et al. 2020

ExRNA

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Neolamarckia cadamba (Roxb.) Bosser (Rubiaceae) is a widespread plant with medicine value and has been used for treating various diseases, such as coughs, fevers, anemia, blood disorders and stomach pains. It had been reported that plant miRNAs might enter mammalian intestines and exert a special ingredient across the different species. However, the knowledge about miRNAs in N.cadamba is scarce. In this study, we first applied high-throughput sequencing to identify miRNAs in N.cadamba. Sequencing revealed a total of 11,285,965 raw reads in the small RNA library of N.cadamba leaves. By bioinformatics analysis, we identified a total of 192 miRNAs, including 167 conserved miRNAs and 25 novel miRNAs, which were distributed among 30 families. Next, we used miRanda to predict the targets of those miRNAs in human, 4030 target genes were predicted. Furthermore, Gene ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses indicated that the identified miRNAs majored in binding, vibrio cholerae infection and insulin signaling, which were likely to provide valuable references for further understanding of medical functions of N. cadamba.

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“…All the drugs were administered four times on the first day (1, 2, 4, and 6 h) and single time on 2nd, 4th, 7th, and 14th day. The crude extracts from A. cadamba have been shown to possess biological activities viz., anti-inflammatory [7] antihepatotoxic activities [8], analgesic activity [9], antimicrobial and anthelmintic activities [10] and hypoglycemic activity [11]. The plant, Anthocephalus cadamba has been reported to contain glycans, saponins, glycoproteins, peptides, amino acids, terpenoids, alkaloids and flavonoids as their chief phytochemical constituents which has been credited for hypoglycemic activity [12][13][14].…”

Section: Preparation Of Test Samplementioning

confidence: 99%

Phytochemical analysis, exploration of antidiabetic and antioxidant potential of Anthocephalus cadamba (Roxb.)

Singh¹,

Irchhaiya²,

Verma³

et al. 2017

IJRDPL

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ABSTRACT:The most common disease nowadays is diabetes. In a fast-changing world, many means to treat diabetes naturally are explored by experts and clinicians today. Continuing use of insulin and other oral hypoglycemic agent creates undesirable side-effects, consequentially, unrestrained increase in blood sugar as well as complications associated with heart diseases; diabetics may have to face. To evade such glitches, herbal medications has superior advantages. As an alternative of using allopathic formulations, it is thus, gainful to use ayurvedic preparations for healthier regulation of diabetes mellitus. Current research was thus taken on to explore the antidiabetic and antioxidant activities of crude extracts and pure compound obtained from the bark of Anthocephalus cadamba. The methanolic extract exhibited promising antidiabetic and antioxidant activity. Grounded on these results, the methanolic extract was fractionated on a silica gel column chromatography in a bioassay-led fractionation resulting in one known isolate, cadambine showing potent anti-diabetic activity, more than that of the positive control, glibenclamide. The results indicated that Anthocephalus cadamba methanolic extract (ACME) and the isolated compound (Cadambine) are potential natural agents to control diabetes. Alloxan significantly induced hyperglycemia; Oral administration of test samples for 14 days caused a significant decrease in blood glucose levels. The possible mechanism by which ACME mediated its antidiabetic effect could be by potentiation of pancreatic secretion of insulin from existing β-cells of islets in the extract treated animals.

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Anthocephalus cadamba (Roxb.) Miq., Rubiaceae, extract shows hypoglycemic effect and eases oxidative stress in alloxan-induced diabetic rats

Cited by 17 publications

References 48 publications

Hypoglycemic and hypolipidemic effects of Solidago chilensis in rats

Hypoglycemic and hypolipidemic effects of Solidago chilensis in rats

Exploration of miRNAs in Neolamarckia cadamba and their potential cross-kingdom functions

Phytochemical analysis, exploration of antidiabetic and antioxidant potential of Anthocephalus cadamba (Roxb.)

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