Anthelmintics for the control of nematode infections in the brushtail possum (<i>Trichosurus vulpecula</i>)

Ralston, M.J.; Stankiewicz, M.; Dd, Heath

doi:10.1080/00480169.2001.36206

Cited by 3 publications

(1 citation statement)

References 2 publications

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“…This is partially demonstrated by our results, where double-dose moxidectin produced a greater decline in FECs than did the other two treatments. In a study of the efficacy of anthelmintics in another marsupial, the common brushtail possum (Trichosurus vulpecula), Ralston et al (2001) found that 5-7 times the manufacturer's recommended dose of various anthelmintics was required to effectively control nematodes (Parastrongyloides trichosuri and Paraustrostrongylus trichosuri).…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Anthelmintic Drugs Against Nematodes Infecting Free-Ranging Eastern Grey Kangaroos, Macropus Giganteus

Cripps

Beveridge

Coulson

2013

Journal of Wildlife Diseases

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ABSTRACT:Effective anthelmintics are valuable tools for biologists conducting manipulative field experiments to examine effects of parasites on wildlife. However, before such experiments are carried out the efficacy of these drugs must be determined. We conducted three field experiments (May 2010-September 2011) on free-ranging eastern grey kangaroos (Macropus giganteus) at a golf course in Victoria, Australia, treating animals with the anthelmintic drugs moxidectin (subcutaneous, 1 mg/kg, 2 mg/kg), ivermectin (subcutaneous, 200 mg/kg), and albendazole (oral, 3.8 mg/kg). After treatment we monitored strongylid fecal egg counts (FECs) over time and assessed anthelmintic efficacy using fecal egg count reduction tests (FECRTs). We also performed a larval development assay (LDA) to evaluate directly the efficacy in the nematode population. Unexpectedly, moxidectin and ivermectin had low efficacy with maximum FEC reductions of 82% and 28%, respectively. However, treatment with albendazole reduced FECs by 100% in all kangaroos and egg counts remained low for up to 3 mo. The results from the LDA supported the FECRTs, with low macrocyclic lactone efficacy and high albendazole efficacy. Macrocyclic lactones, at recommended dose rates, were much less effective against strongylid nematodes in kangaroos than has been reported for domestic herbivores. This may be partly due to pharmacokinetics in the host and partly due to low susceptibility in some of the nematodes infecting eastern grey kangaroos.

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Section: Discussionmentioning

confidence: 99%

The Efficacy of Anthelmintic Drugs Against Nematodes Infecting Free-Ranging Eastern Grey Kangaroos, Macropus Giganteus

Cripps

Beveridge

Coulson

2013

Journal of Wildlife Diseases

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Parastrongyloides trichosuri, a nematode parasite of mammals that is uniquely suited to genetic analysis

Grant

Stasiuk

Newton-Howes

et al. 2006

International Journal for Parasitology

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Comparative Efficacy of the Selected Indigenous Medicinal Plants With a Patent Drug Levamisole Against Ascariasis in Village Poultry

Sarker

Mostofa

Awal

et al. 1970

Bangl. J. Vet. Med.

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The experiment was conducted at the Department of Pharmacology, Bangladesh Agricultural University, Mymensingh, during the period from July 2005 to November 2006 to study the comparative efficacy of indigenous medicinal plants Neem (Azadirachta indica) and Bothua (Chenopodium album) with a patent drug Levamisole (Poulnex®) against Ascariasis. Sixty ascarid infected chickens were randomly divided into 6 equal groups and treatment schedule were as follows: Group A = Controlled (Infected), Group B = Levamisole 30mg/kg b. wt; Group C = Neem 1gm/kg b. wt. (Alcoholic extract); Group D = Neem 1gm/kg b. wt. (crude extract); Group E = Bothua 1gm/kg body wt. (Alcoholic extract) Group F = Bothua 1gm/kg body wt. (Crude extract) orally once at a time and closely observed for 28 days. Fecal egg count (EPG) were 100% reduced in Levamisole and Neem (alcoholic and water extract) treated groups. On the other hand EPG were somewhat increased in other three groups. Body weight TEC, Hb and PCV were increased significantly in above mentioned three groups (Levamisole and both groups of Neem) and decreased in rest three groups but TLC and ESR were decreased significantly. After post mortem examination no parasites were found in three groups of treated poultry (Levamisole and both groups of Neem). Parasites were remained available (17-24 numbers) in rest three groups. So it is concluded that Neem (Azadirachta indica) and levamisole is equally effective but Bothua (Chenopodium album) is completely ineffective against Ascariasis in village poultry.

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Anthelmintics for the control of nematode infections in the brushtail possum (Trichosurus vulpecula)

Abstract: The doses of anthelmintics required to effectively control nematodes in possums were higher than those recommended for animals for which they are currently registered. Possums tolerate the high dose rates of anthelmintics used in this study without apparent adverse effects.

Cited by 3 publications

References 2 publications

The Efficacy of Anthelmintic Drugs Against Nematodes Infecting Free-Ranging Eastern Grey Kangaroos, Macropus Giganteus

The Efficacy of Anthelmintic Drugs Against Nematodes Infecting Free-Ranging Eastern Grey Kangaroos, Macropus Giganteus

Parastrongyloides trichosuri, a nematode parasite of mammals that is uniquely suited to genetic analysis

Comparative Efficacy of the Selected Indigenous Medicinal Plants With a Patent Drug Levamisole Against Ascariasis in Village Poultry

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