Anthelmintic studies: III. A taeniacidal testing technique

Steward, J. S.

doi:10.1017/s0031182000027621

Cited by 19 publications

(13 citation statements)

References 4 publications

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“…The screening technique followed was essentially that of Steward (1955) with slight modifications. The animals were infected by feeding 200 mature viable ova of H. nana.…”

Section: R=n0 2 2r=nh 2 3r=ncsmentioning

confidence: 99%

Anticestode activity of 3, 5-dibromo-2' -chlorosalicylanilide-4' -isothiocyanate—a preliminary report

et al. 1980

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Many compounds have been claimed to possess powerful taenicidal activity but only a few are able to remove the tapeworms complete with scolices; accordingly better drugs are still needed. A series of 3, 5-dibromosalicylanilides, possessing a molecular framework similar to that of niclosamide (Gönnert and Schraufstätter, 1960) was tested for taenicidal activity; the most potent anticestode compound was found to be 3, 5-dibromo-2' -chlorosalicylanilide-4' -isothiocyanate (CDRI Compound 77–6). The present communication compares the efficacy of Compound 77–6 with niclosamide, N-(2' -chloro-4-nitrophenyl)-5-chlorosalicylamid (Bayer, power with 75% active ingredient) and praziquantel, 2-cyclohexylcarbonyl-1–3, 4, 6, 7, 11 b-hexahydro-2H-Pyrazino [2–1-a], isoquinoline-4-one (Droncit, E. Merck & Bayer, powder, 100% pure) (Seubert et al., 1977) in rats and mice.

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“…The screening technique followed was essentially that of Steward (1955) with slight modifications. The animals were infected by feeding 200 mature viable ova of H. nana.…”

Section: R=n0 2 2r=nh 2 3r=ncsmentioning

confidence: 99%

Anticestode activity of 3, 5-dibromo-2' -chlorosalicylanilide-4' -isothiocyanate—a preliminary report

et al. 1980

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“…fraterna: The parasite, isolated from mice, was maintained in a survival medium at 37°C and subjected to the fractions at decreasing doses, according to the methods described by Steward (1955), Sen & Hawking (1960), Crowley (1961), Cavier & Leger (1966) and Un (1966). fraterna: The parasite, isolated from mice, was maintained in a survival medium at 37°C and subjected to the fractions at decreasing doses, according to the methods described by Steward (1955), Sen & Hawking (1960), Crowley (1961), Cavier & Leger (1966) and Un (1966).…”

Section: Bioassaysmentioning

confidence: 99%

Anthelmintic properties of Polygonum glabrum

Muddathir

Balansard²,

Timon‐David³

et al. 1987

Journal of Pharmacy and Pharmacology

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A pure anthelmintic substance (PGA) has been isolated from the methanol-aqueous extract of the leaf of Polygonum glabrum Willd., a semi-aquatic Sudanese species of the family Polygonaceae. The antiparasitic in-vitro activity of several fractions isolated from the plant, has been examined comparatively with that of PGA. PGA also showed molluscicidal activity against Biomphalaria glabrata and Limnea truncatula Müll. Structural determination of PGA was attempted following data analysis of UV, IR, 13C NMR, 1H NMR and MS spectra and suggests that PGA is a terpenoid.

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“…In spite of countless attempts it appears not to have been possible to create an entirely reliable method by which the anthelmintic activity could easily be evaluated. In the screening work recently performed, the dwarf tape worm (Hymenolepis nuna) has been used for in vitro and in vivo tests of mice (Blakemore & others, 1964 ;Bowden, Broadbent & ROSS, 1965 ;Steward, 1955 ;Sen & Hawking, 1960). Unfortunately, results obtained with these methods have proved inconsistent with controlled clinical tests (Rosenghrd, S., Hackman, C .…”

Section: Biological Evaluation Of Dryopteris Constituentsmentioning

confidence: 99%