Anthelmintic resistance of gastrointestinal nematodes in sheep grazing in irrigated and dry areas in the semiarid region of northeastern Brazil

Nascimento, Lauricia S; Evaristo, Anna M C F; Oliveira, Glauber Meneses Barboza de; Ferreira, Matheus Silva; Silva, Déborah L R; Azevêdo, Sérgio Santos de; Yamamoto, Sandra Mari; Araújo, Márcia Medeiros de; Horta, Maurício Cláudio

doi:10.1007/s11250-021-02647-w

Cited by 7 publications

(3 citation statements)

References 18 publications

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“…For decades, the control of gastrointestinal parasites has been based on the application of synthetic anthelmintics, and for horses, there are three classes of broad-spectrum anthelmintics: benzimidazoles (fenbendazole and oxibendazole), tetrahydropyrimidines (pyrantel), and macrocyclic lactones (ivermectin and moxidectin) [27]. Although for years these drugs were a successful control method due to the effectiveness they demonstrated in reducing the parasite load [71], frequent use and inadequate quantity caused their efficacy to decrease [72], and the parasites developed resistance to anthelmintics [2,73].…”

Section: Resistance Of Gastrointestinal Parasites To Synthetic Anthel...mentioning

confidence: 99%

Moringa oleifera as a Natural Alternative for the Control of Gastrointestinal Parasites in Equines: A Review

Elghandour,

Maggiolino,

Vázquez-Mendoza

et al. 2023

Plants

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Studies have shown a wide variety of parasites that infect horses, causing major gastrointestinal damage that can lead to death, and although the main method of control has been synthetic anthelmintics, there are parasites that have developed resistance to these drugs. For generations, plants have been used throughout the world as a cure or treatment for countless diseases and their symptoms, as is the case of Moringa oleifera, a plant native to the western region. In all its organs, mainly in leaves, M. oleifera presents a diversity of bioactive compounds, including flavonoids, tannins, phenolic acids, saponins, and vitamins, which provide antioxidant power to the plant. The compounds with the greatest antiparasitic activity are tannins and saponins, and they affect both the larvae and the oocytes of various equine gastrointestinal parasites. Therefore, M. oleifera is a promising source for the natural control of gastrointestinal parasites in horses.

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Section: Resistance Of Gastrointestinal Parasites To Synthetic Anthel...mentioning

confidence: 99%

Moringa oleifera as a Natural Alternative for the Control of Gastrointestinal Parasites in Equines: A Review

Elghandour,

Maggiolino,

Vázquez-Mendoza

et al. 2023

Plants

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“…Nevertheless, the excessive dependence on these substances has led to the development of anthelmintic resistance (AR) in all species of domestic ruminants to all classes of anthelmintics [15]. In Europe [16][17][18], Africa [19][20][21], Asia [22,23], Oceania [24][25][26] and the Americas [27][28][29][30], this phenomenon is associated with multiple drugs, threatening the viability of ruminant livestock production, especially small ruminants [18,31,32].…”

Section: Introductionmentioning

confidence: 99%

An Overview of Anthelmintic Resistance in Domestic Ruminants in Brazil

Macedo,

Silva,

Alves

et al. 2023

Ruminants

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Gastrointestinal nematodes (GIN) significantly, negatively impact livestock worldwide, and their control depends on the use of chemotherapy drugs. However, this approach is unsustainable as anthelmintic resistance (AR) is growing widespread. This article provides a comprehensive overview of the historical and current data published on AR in domestic ruminants in Brazil. Alternative measures of GIN control have been discussed to provide helpful information to prevent the development of AR in the country. This review consisted of a search of technical and scientific publications between January 1960 to January 2023, using online sources such as PubMed, Scielo and Google Scholar. Eighty-three articles published over the last six decades reporting AR in sheep (n = 43), goats (n = 20) and cattle (n = 20) were included. A total of 37.3%, 25.4% and 37.3% evaluated one, two and three or more molecule classes, respectively. Among all studies, 82.1% used fecal egg count reduction test as a method of AR diagnosis. In conclusion, AR is an urgent and emerging issue for ruminant production in Brazil. It is necessary to evaluate on a large scale the distribution and management of anthelmintic drugs and discuss strategies that delay this phenomenon’s development.

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“…In sheep, GIN can produce anemia, diarrhea and severe protein loss. In addition, parasitism can have indirect consequences on the metabolism by an increased susceptibility to other pathogens [ 1 , 2 , 3 ]. Benzimidazoles, salicylanilides, imidazothiazoles and macrocyclic lactones are widely used to control GIN [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Poloxamer 407/188 Binary Thermosensitive Gel as a Moxidectin Delivery System: In Vitro Release and In Vivo Evaluation

Ruan

et al. 2022

Molecules

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Moxidectin (MXD) is an antiparasitic drug used extensively in veterinary clinics. In this study, to develop a new formulation of MXD, a thermosensitive gel of MXD (MXD-TG) was prepared based on poloxamer 407/188. Furthermore, the gelation temperature, the stability, in vitro release kinetics and in vivo pharmacokinetics of MXD-TG were evaluated. The results showed that the gelation temperature was approximately 27 °C. MXD-TG was physically stable and can be released continuously for more than 96 h in vitro. The Korsmeyer–Peppas model provided the best fit to the release kinetics, and the release mechanism followed a diffusive erosion style. MXD-TG was released persistently for over 70 days in sheep. Part of pharmacokinetic parameters had a difference in female and male sheep (p < 0.05). It was concluded that MXD-TG had a good stability, and its release followed the characteristics of a diffusive erosion style in vitro and a sustained release pattern in vivo.

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Anthelmintic resistance of gastrointestinal nematodes in sheep grazing in irrigated and dry areas in the semiarid region of northeastern Brazil

Cited by 7 publications

References 18 publications

Moringa oleifera as a Natural Alternative for the Control of Gastrointestinal Parasites in Equines: A Review

Moringa oleifera as a Natural Alternative for the Control of Gastrointestinal Parasites in Equines: A Review

An Overview of Anthelmintic Resistance in Domestic Ruminants in Brazil

Poloxamer 407/188 Binary Thermosensitive Gel as a Moxidectin Delivery System: In Vitro Release and In Vivo Evaluation

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