Anthelmintic resistance: is a solution possible?

Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain

“…However, due to the widespread use of anthelmintic drugs, extensive anthelmintic drug resistance has developed in many parasitic nematode species of livestock [ 12 ]. Anthelmintic resistance has been reported in Haemonchus contortus , Cooperia spp., and Ostertagia ostertagi infecting sheep in Europe [ 13 ].…”

“…Anthelmintic resistance has been reported in Haemonchus contortus , Cooperia spp., and Ostertagia ostertagi infecting sheep in Europe [ 13 ]. In addition, anthelmintic-resistant parasitic nematodes in sheep, cattle and goats have been reported in a number of countries, including Brazil, Argentina, the United States, Australia, New Zealand, and South Africa (reviewed [ 12 ]). Furthermore, there are growing concerns that mass drug administration (MDA) programs are selecting for anthelmintic resistance among helminths that infect humans [ 14 , 15 ].…”

Natural products as anthelmintics: safeguarding animal health

“…We also draw attention to several recent reviews that have analysed plant anthelmintics, including crude extracts. [10][11][12][13][14][15][16][17][18][19] 3.1 Alkaloids Emetine (3.01) is the major alkaloid of the Central American owering plant Carapichea ipecacuanha (Rubiaceae, synonym Cephaelis ipecacuanha; common name ipecacuanha), whose root has traditionally been used as an emetic (a substance to induce vomiting). 20,21 Of note, 3.01 was active (EC 100 3 mg kg −1 ) when administered intramuscularly in an F. hepatica (immature liver uke) sheep infection model.…”

Bringing livestock back into the fold: Animal research in the Annals of Applied Biology—Past, present and future

“…Obviously, our knowledge and understanding of these issues has expanded, sometimes exponentially, but the challenges caused by animal disease and infestation and compromised health and welfare continue. For example, parasites and their impact on animal health and food security remain as salient in the 21st century as they were in the 20th, further complicated by the increasing development of parasite resistance to therapeutic veterinary pharmaceutical products, particularly anthelmintics (Ahuir-Baraja, Cibot, Llobat, & Garijo, 2021). This increasing resistance problem hinders our ability to treat livestock to kill the external and internal parasites causing health and welfare problems, and makes applied research and new husbandry methods and technologies as relevant as ever (Fitzpatrick, 2013).…”