Anthelmintic resistance in non-strongylid parasites of horses

Reinemeyer, Craig R.

doi:10.1016/j.vetpar.2011.10.009

Cited by 71 publications

(63 citation statements)

References 21 publications

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“…However, these results support the recommendation that the efficacy of available drug classes against Parascaris spp. and other equine parasites should be monitored regularly by FECR testing (Veronesi et al 2009;Reinemeyer 2012). In addition, although the animals were selected for being infected by Parascaris spp., the appearance of other parasites pre-and post-treatment might indicate some resistance which needs further investigations.…”

Section: Discussionmentioning

confidence: 99%

A field study on the anthelmintic resistance of Parascaris spp. in Arab foals in the Riyadh region, Saudi Arabia

Alanazi

Mukbel

Alyousif

et al. 2017

Veterinary Quarterly

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Background: In the last decade, Parascaris spp. resistance to anthelmintics has been recorded in many countries. In Saudi Arabia, there are limited data available on Parascaris spp. resistance to anthelmintics. Objective: To determine the current status of ivermectin, abamectin and praziquantel combined, and fenbendazole resistance to Parascaris spp. in horses in Saudi Arabia. Methods: Three hundred and forty-one foals from eleven different farms were examined by faecal egg count (FEC). The foals were all Arab horses aged 17.2 § 4.5 (SD) months. Ivermectin (n = 46 foals), abamectin and praziquantel combined (n = 46), and fenbendazole (n = 46) were administered on day 0 and faeces were collected on day 14. The study comprised 41 untreated foals as controls. Animals that have FEC of 100 eggs per gram (EPG) were used to measure anthelmintic efficacy. Parascaris spp. populations were considered susceptible when faecal egg count reduction (FECR) was 95% associated with a lower 95% confidence limit (LCL) >90%, suspected resistant when FECR 90% or LCL <90% and resistant when FECR <90% and LCL <90%. Results: Prevalence of Parascaris spp. infection was 53% (179/341 horses). Anthelmintic resistance to Parascaris spp. were highest following fenbendazole (55% of farms and 65% of foals) and to a lower extent following ivermectin or the combination of abamectin and praziquantel which comprised 27% of farms (and 46% of foals) and 18% of farms (and 10% of foals), respectively. Conclusion: These data indicate that anthelmintics-resistant Parascaris spp. populations are present on horse farms in Saudi Arabia.

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Section: Discussionmentioning

confidence: 99%

A field study on the anthelmintic resistance of Parascaris spp. in Arab foals in the Riyadh region, Saudi Arabia

Alanazi

Mukbel

Alyousif

et al. 2017

Veterinary Quarterly

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“…Gene expression studies in phenotypes that are resistant and susceptible to helminth infection have primarily been conducted in sheep, cattle, and rodent models; however, the results are difficult to compare for a number of reasons, e.g., different tissues examined (mucosa, lymph nodes), infection with different parasite species, use of different gene expression platforms (microarray, qPCR), or use of host animals that cannot easily be compared between studies. As an example, some use different breeds or rodent strains whereas others compare resistant and susceptible lines from resource flocks developed by selection and assortative mating for several generations (Pernthaner et al 2005;Ingham et al 2008), or measure gene expression in the most resistant and susceptible animals in a flock after trickle or natural infection (Araujo et al 2009;Zaros et al 2010;Gossner et al 2012;2013). Nevertheless, ovine studies using lymph nodes or lymph cells have found an increased expression of IL-13 but not IL-4 in resistant animals compared to susceptible animals (Pernthaner et al 2005;Gossner et al 2013).…”

Section: Disscussionmentioning

confidence: 99%

Transcriptional immune response in mesenteric lymph nodes in pigs with different levels of resistance to Ascaris suum

Skallerup

Nejsum

Cirera

et al. 2017

Acta Parasitologica

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“…Ivermectin wirkt beim Pferde sowohl gegen die migrierenden Larven als auch gegen die intestinalen Stadien, wodurch das Refugium im Wirt eliminiert wird (Reinemeyer 2012 Anwendung des Prinzips der selektiven Entwurmung, zeigte sich bei Felduntersuchungen in Dänemark, wo eine individuelle Befunderhebung vor anthelminthischer Behandlung seit einigen Jahren vorgeschrieben ist (Nielsen et al 2006(Nielsen et al , 2012a(Nielsen et al , 2012b. Pferde auf Betrieben die angaben grundsätzlich nach den Prinzipien der selektiven Entwurmung vorzugehen, zeigten eine Pferde-resp.…”

Section: Refugium Parascaris Equorum/univalensunclassified

Current state of anthelmintic resistance in horses with a special focus on the situation in Germany

Ertelt¹,

Samson‐Himmelstjerna²,

Gehlen³

2016

PHK

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Current state of anthelmintic resistance in horses with a special focus on the situation in GermanyThe occurrence of anthelmintic resistance has been reported soon after the introduction of well tolerated broad-spectrum anthelmintics in the 1960s. Like in bacteria the development of resistance in gastro-intestinal parasites of equines is a consequence of repeated drug application and represents an evolutionary process. In Germany, resistance has been detected in small strongyles to benzimidazole (several studies with up to ca. 80 % resistance frequency) and tetrahydropyrimidine (several studies with up to ca. 25 % resistance frequency), in ascarids to macrocyclic lactones (single study on one farm) and recently in pinworms to ivermectin (macrocyclic lactone) (single study on one farm). Once anthelmintic resistance is established it remains in the worm population even if the particular drug class is not used over a longer period of time. Today different tests are available for detection of anthelmintic resistance. Despite limitations, the FECRT remains the test of choice in horses. Different worm control concepts have been established to delay the development of resistance. Any sustainable worm control strategy targets the least frequent application of anthelmintics that does not harm the health and well-being of the horse. The targeted selective treatment that has been developed for the prevention of anthelmintic resistance in small ruminants can only be used in horses with limitations and will be further discussed in this review.

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Anthelmintic resistance in non-strongylid parasites of horses

Cited by 71 publications

References 21 publications

A field study on the anthelmintic resistance of Parascaris spp. in Arab foals in the Riyadh region, Saudi Arabia

A field study on the anthelmintic resistance of Parascaris spp. in Arab foals in the Riyadh region, Saudi Arabia

Transcriptional immune response in mesenteric lymph nodes in pigs with different levels of resistance to Ascaris suum

Current state of anthelmintic resistance in horses with a special focus on the situation in Germany

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