“…Nitazoxanide is bio-transformed into active metabolite tizoxanide after absorption in mammals. Both nitazoxanide and tizoxanide have mitochondrial uncoupling effects 17 , 18 , 35 , 36 . Nitazoxanide has been a clinical antiprotozoal drug with good safety profile, in the present study, we found that nitazoxanide and its metabolite tizoxanide extended the healthspan of wild type C. elegans , improved the shortened C. elegans lifespan induced by high-glucose.…”