Anthelmintic, anti-inflammatory and antioxidant effects of Garcinia mangostana extract in hamster opisthorchiasis

Aukkanimart, Ratchadawan; Boonmars, Thidarut; Sriraj, Pranee; Songsri, Jiraporn; Laummaunwai, Porntip; Waraasawapati, Sakda; Boonyarat, Chantana; Rattanasuwan, Panaratana; Boonjaraspinyo, Sirintip

doi:10.1016/j.exppara.2015.03.007

Cited by 11 publications

(5 citation statements)

References 32 publications

(34 reference statements)

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“…The DPPH results of YN oil indicate no antioxidant activity, which is similar to a previous report [26]. For the other two herbs, the analysis of IC 50 showed that R. nasutus and G. mangostana pericarp extracts have a high antioxidant activity, which is supported by previous studies [22,39]. This could be responsible for the added benefit of adding these two herbs in this study.…”

Section: Discussionsupporting

confidence: 90%

“…WC contains rhinacanthin, which has various activities, such as anti-inflammatory [ 36 ], melanogenesis suppression [ 37 ], and antifungal activities. Finally, the major compound of MG is alpha-mangostin, which exhibits anti-inflammatory and antioxidant activities [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…MG was purchased from a local market. MG extracts were prepared as in our previous study [ 22 ]. Briefly, fresh MG pericarps were incubated at 60°C, and then, the dried MG pericarps were macerated with ethanol at room temperature for 3 weeks.…”

Section: Methodsmentioning

confidence: 99%

“…G. mangostana, also known as mangosteen (MG), is a tropical fruit found in Southeast Asia. It has antioxidant, antiparasitic, and anticancer effects [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Dipterocarpus alatus oil combination with Rhinacanthus nasutus leaf and Garcinia mangostana pericarps against canine demodicosis

et al. 2021

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Background and Aim: Canine demodicosis is a skin disease that is a major global health problem in dogs. Ivermectin is a drug of choice for treatment, but it may cause toxicity in dogs carrying multidrug resistance mutation-1 gene mutations. Hence, alternative herbal medicines are used instead of the drug, such as Dipterocarpus alatus oil (YN oil), Rhinacanthus nasutus leaf (WC), and Garcinia mangostana pericarps (MG) extracts. This study aimed to determine the efficacy of D. alatus oil, R. nasutus leaf, and G. mangostana pericarp extracts on canine demodicosis in vivo. Materials and Methods: Twenty-five mixed-breed dogs with localized demodicosis were examined. Dogs were diagnosed with demodicosis through deep skin scraping and screened with the inclusion criteria. Five dogs of each group were treated in five treatment groups (ivermectin, YN oil, YN oil+WC, YN oil+MG, and YN oil+WC+MG) for 1 month. The individual dogs were clinically evaluated, and the dermatological lesions were monitored daily for 60 days. Results: Dermatological lesion improvement was predominantly observed in the group of dogs treated with YN oil+WC. This was evidenced by the disappearance of the hyperpigmentation and lichenification on day 28 post-treatment and alopecia on day 56 post-treatment. Moreover, no allergic or clinical signs were observed during treatment. Conclusion: YN oil+WC is an alternative herbal medicine that could be used for the treatment of localized canine demodicosis.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…G. mangostana, also known as mangosteen (MG), is a tropical fruit found in Southeast Asia. It has antioxidant, antiparasitic, and anticancer effects [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Dipterocarpus alatus oil combination with Rhinacanthus nasutus leaf and Garcinia mangostana pericarps against canine demodicosis

et al. 2021

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“…Mangostin is the most common of these xanthones (MAG) [4]. It serves a variety of purposes by acting as an anti-inflammatory, antioxidant, cancer-preventative, allergy-relieving, antibacterial, antifungal, antiviral and antimalarial agent [5][6][7][8][9][10][11][12][13][14][15]. Figure 1b depicts the chemical composition of MAG.…”

Section: Introductionmentioning

confidence: 99%

Green micellar spectrofluorimetric determination of α‐mangostin found in herbal products as antioxidant and other biological activities beneficial to human health

et al. 2023

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Pharmaceutical product quality control (QC) needs quick, sensitive and economical procedures to deliver high throughput at low cost, which is the key factor considered by such economic facilities. To lessen the risky effects of research laboratories, researchers must take into account the ecological impacts. α‐Mangostin (MAG) exhibit anti‐inflammatory, antioxidant, anticancer, anti‐allergic, antibacterial, antifungal, antiviral and antimalarial activities. Based on the spectrofluorimetric approach, a novel straightforward, sensitive and environmentally friendly method for MAG determination was developed and validated. Many variables were investigated to improve MAG native fluorescence, including solvent type, buffers, pH and additional surfactants. The best MAG fluorescence sensitivity was found in Britton–Robinson buffer (pH 4) at 450 nm after irradiation at 350 nm in the concentration range of 5–50 ng ml−1. The technique was successfully used to determine the presence of MAG in both its approved dose forms and in samples of spiked human plasma, as per FDA standards for validation. According to their evaluation on two recent greenness criteria (GAPI [Green Analytical Procedure Index] and AGREE [Analytical GREEnness]), the suggested approach has been shown to be environmentally beneficial because it normally uses biodegradable chemicals in solvent‐free aqueous phases.

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Mangosteen Xanthones: Bioavailability and Bioactivities

Failla

Gutiérrez‐Orozco

2017

Fruit and Vegetable Phytochemicals

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Anthelmintic, anti-inflammatory and antioxidant effects of Garcinia mangostana extract in hamster opisthorchiasis

Cited by 11 publications

References 32 publications

Efficacy of Dipterocarpus alatus oil combination with Rhinacanthus nasutus leaf and Garcinia mangostana pericarps against canine demodicosis

Efficacy of Dipterocarpus alatus oil combination with Rhinacanthus nasutus leaf and Garcinia mangostana pericarps against canine demodicosis

Green micellar spectrofluorimetric determination of α‐mangostin found in herbal products as antioxidant and other biological activities beneficial to human health

Mangosteen Xanthones: Bioavailability and Bioactivities

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