Anthelmintic and metabolomic analyses of chicory (Cichorium intybus) identify an industrial by-product with potent in vitro antinematodal activity

Pena-Espinoza, Miguel Angel; Valente, Angela H.; Bornancin, Louis; Simonsen, Henrik Toft; Thamsborg, Stig Milan; Williams, Andrew R.; López‐Muñoz, Rodrigo

doi:10.1016/j.vetpar.2020.109088

Cited by 22 publications

(18 citation statements)

References 49 publications

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“…Seaweed samples were extracted with two protocols leading to three extracts, using a similar approach as previously published ( Peña-Espinoza et al, 2020 ). For the hexane extraction, 30 g of seaweed was extracted three times at room temperature, with 100 ml of hexane and 10 min sonication.…”

Section: Methodsmentioning

confidence: 99%

Bio-Guided Fractionation and Molecular Networking Reveal Fatty Acids to Be Principal Anti-Parasitic Compounds in Nordic Seaweeds

Bonde

Bornancin

et al. 2021

Front. Pharmacol.

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Widespread use of antimicrobial drugs has led to high levels of drug-resistance in pathogen populations and a need for novel sources of anti-bacterial and anti-parasitic compounds. Macroalgae (seaweed) are potentially a rich source of bioactive compounds, and several species have traditionally been used as vermifuges. Here, we investigated the anti-parasitic properties of four common cold-water Nordic seaweeds; Palmaria palmata (Rhodophyta), Laminaria digitata, Saccharina latissima and Ascophyllum nodosum (Ochrophyta, Phaeophyceae). Screening of organic extracts against helminths of swine (Ascaris suum) and sheep (Teladorsagia circumcincta) revealed that S. latissima and L. digitata had particularly high biological activity. A combination of molecular networking and bio-guided fractionation led to the isolation of six compounds from extracts of these two species identified in both fermented and non-fermented samples. The six isolated compounds were tentatively identified by using MS-FINDER as five fatty acids and one monoglyceride: Stearidonic acid (1), Eicosapentaenoic acid (2), Alpha-Linolenic acid (3), Docosahexaenoic acid (4), Arachidonic acid (5), and Monoacylglycerol (MG 20:5) (6). Individual compounds showed only modest activity against A. suum, but a clear synergistic effect was apparent when selected compounds were tested in combination. Collectively, our data reveal that fatty acids may have a previously unappreciated role as natural anti-parasitic compounds, which suggests that seaweed products may represent a viable option for control of intestinal helminth infections.

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Section: Methodsmentioning

confidence: 99%

Bio-Guided Fractionation and Molecular Networking Reveal Fatty Acids to Be Principal Anti-Parasitic Compounds in Nordic Seaweeds

Bonde

Bornancin

et al. 2021

Front. Pharmacol.

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“…Recently, MolNetEnhancer was used to demonstrate that sesquiterpene lactones, flavonoids, fatty acids, and fatty acid amides of various chicory ( Cichorium intybus L.) cultivars displayed bioactivity against the parasitic helminth Ascaris suum . 71 Furthermore, the workflow was used to assess the wide range of natural products of the filamentous fungus Paecilomyces sp. CMAA1686 isolated from a cemetery in Brazil, which includes pharmacologically active scorpionicidal (against Tityus serrulatus ) terpene lactones, phenylpropanoids, and alkaloids.…”

Section: Network-based Ms-based Metabolomics Toolsmentioning

confidence: 99%

Advances in decomposing complex metabolite mixtures using substructure- and network-based computational metabolomics approaches

et al. 2021

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“…Drugs from herbal/natural sources are more striking than the drug prepared from synthetic means due to many reasons such as affordability, diversity, accessibility with lesser effects [58]. A huge diversity of bioactive components exists in variety of phytochemicals also draws the therapeutic significance of chicory [59,60]. The content of phytochemicals may differ in whole plant/precise section of the herb and in the extracted material.…”

Section: Need Of Cichorium Intybus For 'Phytotherapy'mentioning

confidence: 99%

“…Aqueous decoction Anti-ulcerogenesis [95] Ethyl acetate extract Antifungal [75] Ethanolic extract Tumor-inhibitory [105] Methanolic extract Wound healing [23] Aqueous extracts Antihepatotoxic [87] Aqueous extract Anti-malarial [106] Natural chicoric acid extract Anti-hyperglycemic [107] 'Magnolialide'(from root) Tumor-inhibitory [108] Aqueous-alcoholic extract Immunoactivity [109] Extract (rich in chicoric acid) Antidiabetic [19] Chicory root pulp Anthelmintic [60] Extracts rich in sesquiterpene lactones Anti-inflammatory [88] Alcoholic and aqueous extracts Hepatoprotective [86] Ethanolic and aqueous extracts Anti-inflammatory [3] Hydroalcoholic extract Beneficial effects on pyridoxine-induced peripheral neuropathy [110]…”

Section: Rootmentioning

confidence: 99%

Contemporary Insights on Antibacterial and Pharmacological Importance of Cichorium intybus: A Compendious Review

Upadhayay¹,

Pandey²,

Samantaray³

et al. 2021

BJSTR

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The astonishing medicinal herb Cichorium intybus is well-known for its huge therapeutic potential. It is an important element of ethnic medication systems practiced in different regions of globe and also consumed as salad or vegetable. A broad spectrum of phytochemicals (chicoric acid, cinnamic acid, caftaric acid, coumarin, anthocynine, triterpenoids, chlorogenic acids, sesquiterpene lactones, caffeic acid, phenolics, flavonoids, inulin, tannin and other chemical entities) in various plant parts have been explored, identified and validated for some medicinal uses. The antibacterial traits of herbal extracts have been depicted against bacteria to diminish the rampant use of synthetic antibiotics. The hepatoprotective, anti-diabetic antioxidant, anti-inflammation, antimalarial, antiproliferative, Immunoactivity and other pharmacological benefits of extract or bioactive compounds were compiled. In this study, a plenty of features including ethnic uses, phytochemical constituents, antibacterial activity, and pharmacological application of Cichorium intybus are described concisely, that may offer an authentic source for further development and exploration of Cichorium intybus for its promising medicinal application.

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Anthelmintic and metabolomic analyses of chicory (Cichorium intybus) identify an industrial by-product with potent in vitro antinematodal activity

Cited by 22 publications

References 49 publications

Bio-Guided Fractionation and Molecular Networking Reveal Fatty Acids to Be Principal Anti-Parasitic Compounds in Nordic Seaweeds

Bio-Guided Fractionation and Molecular Networking Reveal Fatty Acids to Be Principal Anti-Parasitic Compounds in Nordic Seaweeds

Advances in decomposing complex metabolite mixtures using substructure- and network-based computational metabolomics approaches

Contemporary Insights on Antibacterial and Pharmacological Importance of Cichorium intybus: A Compendious Review

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