Anthelmintic activity of Pistacia lentiscus foliage in two Middle Eastern breeds of goats differing in their propensity to consume tannin-rich browse

Landau, S.; Azaizeh, Hassan; Muklada, H.; Glasser, Tzach; Ungar, Eugene D.; Baram, H.; Abbas, Nadeem; Markovics, Alex

doi:10.1016/j.vetpar.2010.07.006

Cited by 52 publications

(19 citation statements)

References 26 publications

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“…These include inhibition of L3 migration and L4 motility with Ascaris suum, as well as L1 feeding inhibition, adult motility assays of Ostertagia ostertagi and Cooperia oncophora, and larval exsheathment inhibition of Haemonchus contortus and Trichostrongylus colubriformis of L3 larvae (Brunet and Hoste 2006;Quijada et al, 2015;Desrues et al, 2016a;Ramsay et al, 2016). These in vivo trials found better host resilience and lower fecal egg counts of H. contortus, Teladorsagia circumcincta, and T. colubriformis and of a mixed gastrointestinal nematode infection, which were attributed to lower worm fecundity (Niezen et al, 1995(Niezen et al, , 1998aPaolini et al, 2005;Landau et al, 2010), and also lower Eimeria oocyst counts . These in vivo trials found better host resilience and lower fecal egg counts of H. contortus, Teladorsagia circumcincta, and T. colubriformis and of a mixed gastrointestinal nematode infection, which were attributed to lower worm fecundity (Niezen et al, 1995(Niezen et al, , 1998aPaolini et al, 2005;Landau et al, 2010), and also lower Eimeria oocyst counts .…”

Section: Antiparasitic Effects Of Prodelphinidins and Galloylated Conmentioning

confidence: 96%

Benefits of Condensed Tannins in Forage Legumes Fed to Ruminants: Importance of Structure, Concentration, and Diet Composition

et al. 2019

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Condensed tannins (CTs) account for up to 20% of the dry matter in forage legumes used as ruminant feeds. Beneficial animal responses to CTs have included improved growth, milk and wool production, fertility, and reduced methane emissions and ammonia volatilization from dung or urine. Most important is the ability of such forages to combat the effects of gastrointestinal parasitic nematodes. Inconsistent animal responses to CTs were initially attributed to concentration in the diet, but recent research has highlighted the importance of their molecular structures, as well as concentration, and also the composition of the diet containing the CTs. The importance of CT structural traits cannot be underestimated. Interdisciplinary research is the key to unraveling the relationships between CT traits and bioactivities and will enable future on‐farm exploitation of these natural plant compounds. Research is also needed to provide plant breeders with guidelines and screening tools to optimize CT traits, in both the forage and the whole diet. In addition, improvements are needed in the competitiveness and agronomic traits of CT‐containing legumes and our understanding of options for their inclusion in ruminant diets. Farmers need varieties that are competitive in mixed swards and have predictable bioactivities. This review covers recent results from multidisciplinary research on sainfoin (Onobrychis Mill. spp.) and provides an overview of current developments with several other tanniniferous forages. Tannin chemistry is now being linked with agronomy, plant breeding, animal nutrition, and parasitology. The past decade has yielded considerable progress but also generated more questions—an enviable consequence of new knowledge!

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Section: Antiparasitic Effects Of Prodelphinidins and Galloylated Conmentioning

confidence: 96%

Benefits of Condensed Tannins in Forage Legumes Fed to Ruminants: Importance of Structure, Concentration, and Diet Composition

et al. 2019

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“…Goat kids from the Mamber breed, which generally exhibit low propensity to consume the antiparasitic shrub Pistacia lentiscus [56], increased their preference for this plant following infection with 10,000 L3 larvae of mixed gastrointestinal nematodes, suggesting therapeutic self-medication [2]. In contrast, goat kids from the Damascus breed typically ingest high amounts of the aforementioned plant irrespective of infection [25], thus exhibiting prophylactic self-medication.…”

Section: Evidence Of Self-medication In Parasitized Ruminantsmentioning

confidence: 99%

“…Indeed, Mediterranean goats in tannin-rich environments will typically ingest 1 g/kg BW of PEG-binding tannins [25], which is the dose needed to suppress fecal excretion of nematode eggs almost entirely [56]. However, many antiparasitic medicines found in nature are secondary compounds, which evolved to deter herbivory by inducing negative post-ingestive effects [66].…”

Section: The Triggers For Self-medication In Ruminantsmentioning

confidence: 99%

“…Mediterranean goats consume tannin-rich Pistacia lentiscus even at times of plentiful green herbage, and educate their kids to consume the plant in high (Damascus goats) or moderate amounts (Mamber goats) [24]. This could be the basis of self-medication behavior, as ingesting P. lentiscus foliage decreases the incidence of nematode eggs in feces to almost zero [56] and impairs development of gastrointestinal larvae [4]. By educating their kids to consume P. lentiscus moderately [24], Mamber does prepare the ground for therapeutically increased intake of this shrub in case of infection.…”

Section: The Triggers For Self-medication In Ruminantsmentioning

confidence: 99%

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Ruminant self-medication against gastrointestinal nematodes: evidence, mechanism, and origins

et al. 2014

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Gastrointestinal helminths challenge ruminants in ways that reduce their fitness. In turn, ruminants have evolved physiological and behavioral adaptations that counteract this challenge. Ruminants display anorexia and avoidance behaviors, which tend to reduce the incidence of parasitism. In addition, ruminants appear to learn to self-medicate against gastrointestinal parasites by increasing consumption of plant secondary compounds with antiparasitic actions. This selective feeding improves health and fitness. Here, we review the evidence for self-medication in ruminants, propose a hypothesis to explain self-medicative behaviors (based on post-ingestive consequences), and discuss mechanisms (e.g., enhanced neophilia, social transmission) that may underlie the ontogeny and spread of self-medicative behaviors in social groups. A better understanding of the mechanisms that underlie and trigger self-medication in parasitized animals will help scientists devise innovative and more sustainable management strategies for improving ruminant health and well-being.

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“…The GIN parasites constrain small ruminant production and thus reduce the growth, milk yield, and death of animals in pastoral grazing systems in Eastern Africa (Waller 1997). It has been demonstrated that feeding high PA content diets to goats significantly reduced the count of gastrointestinal nematode and helminth fecal egg (Kahiya et al 2003;Shaik et al 2006;Terrill et al 2009;Landau et al 2010;Debela et al 2012), which were also demonstrated in sheep (Max et al 2007(Max et al , 2009. The anthelmintic effects of PA were a dosedependent way (Molan et al 2003), while high levels of PAs also have anti-nutritive effects (Tanner et al 1995).…”

Section: Introductionmentioning

confidence: 99%

Production and transcriptional regulation of proanthocyanidin biosynthesis in forage legumes

Zhou

Wei

Sun

et al. 2015

Appl Microbiol Biotechnol

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Proanthocyanidins (PA), also known as condensed tannins, contribute to important forage legumes traits including disease resistance and forage quality. PA in forage plants has both positive and negative effects on feed digestibility and animal performance. The analytical methods and their applicability in measuring the contents of PA in forage plants are essential to studies on their nutritional effects. In spite of important breakthroughs in our understanding of the PA biosynthesis, important questions still remain to be answered such as the PA polymerization and transport. Recent advances in the understanding of transcription factor-mediated gene regulation mechanisms in anthocyanin and PA biosynthetic pathway in model plants suggest new approaches for the metabolic engineering of PA in forage plants. The present review will attempt to present the state-of-the-art of research in these areas and provide an update on the production and metabolic engineering of PA in forage plants. We hope that this will contribute to a better understanding of the ways in which PA production to manipulate the content of PA for beneficial effects in forage plants.

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Anthelmintic activity of Pistacia lentiscus foliage in two Middle Eastern breeds of goats differing in their propensity to consume tannin-rich browse

Cited by 52 publications

References 26 publications

Benefits of Condensed Tannins in Forage Legumes Fed to Ruminants: Importance of Structure, Concentration, and Diet Composition

Benefits of Condensed Tannins in Forage Legumes Fed to Ruminants: Importance of Structure, Concentration, and Diet Composition

Ruminant self-medication against gastrointestinal nematodes: evidence, mechanism, and origins

Production and transcriptional regulation of proanthocyanidin biosynthesis in forage legumes

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