Anthelmintic Activity of Curcuma Aeruginosa Roxb Extract on Fasciola gigantica in Vitro

Vanda, Henni; Parindra, Rizki; Hambal, Muhammad; Athaillah, Farida

doi:10.1051/e3sconf/202015101046

Cited by 6 publications

(8 citation statements)

References 8 publications

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“…Another plant which has anthelmintic potential against F. gigantica in vitro is Curcuma aeruginosa Robx [20]. The methanolic extract of this rhizome also could impact on tegument, reproductive organs, and gastrointestinal tract, all of which similar to the finding in our experiment.…”

Section: Mortality Time Of F Gigantica Histopathological Findingsupporting

confidence: 88%

Pathological Changes of Fasciola gigantica After Treatment with Nigella sativa in Vitro

Hambal¹,

Hidayah²,

Balqis³

et al. 2021

Advances in Biological Sciences Research

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Black cumin (Nigella sativa) has been traditionally used as medicine for various infectious and non-infectious diseases, such as skin infection, conjunctivitis, hypertension, gastrointestinal problems, diabetes, and diarrhea. This study aimed at finding out the effect of black cumin, N. sativa on the survival and pathological changes of liver flukes Fasciola gigantica in vitro. The seeds of N. sativa were extracted with maceration using methanol. Mature F. gigantica flukes were stored in PBS solution and treated with different concentrations of N. sativa extract namely 10% (T1), 25% (T2), and 50% (T3). Similar experiment using Albendazole 0.24 mg/ml and 1xPBS was used as positive (C1) and negative (C2) controls, respectively. All treatments were done at room temperature. The dead flukes were further examined for histopathological changes. The results showed that 50% concentration of extract killed all flukes within 15 minutes, much faster than caused by albendazole (30 minutes). In T2 (25% extract), all flukes were died in 31.5 minutes. The extract of N. sativa caused severe disruption of tegument, the alteration of internal organs, and the absence of tegument spine. The intestine showed inflammation with severity levels were in line with the extract concentration. There was also disintegration of testicular cells observed in the flukes treated with black cumin. In conclusion, N. sativa seed extract has potential medical property against F. gigantica in vitro.

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Section: Mortality Time Of F Gigantica Histopathological Findingsupporting

confidence: 88%

Pathological Changes of Fasciola gigantica After Treatment with Nigella sativa in Vitro

Hambal¹,

Hidayah²,

Balqis³

et al. 2021

Advances in Biological Sciences Research

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“…Jeyathilakan et al [15], who conducted similar research using Allium sativum, reported that 100 g/ml extract of A. sativum was effective in inhibiting and killing F. gigantica. Furthermore, Vanda et al [8] described that 25% and 50% Curcuma aeruginosa extract had the ability to kill F. gigantica within 48 and 60 minutes, respectively. Apparently, our results weres more comparable to the report of Vanda et al [8] than to the report of Jeyathilakan et al [15].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Vanda et al [8] described that 25% and 50% Curcuma aeruginosa extract had the ability to kill F. gigantica within 48 and 60 minutes, respectively. Apparently, our results weres more comparable to the report of Vanda et al [8] than to the report of Jeyathilakan et al [15].…”

Section: Discussionmentioning

confidence: 99%

“…Herbal medicine has several advantages over chemical drugs such as low cost, easy to obtain, abundant availability in nature, slight side effect, and less resistant. There are various plants which have been investigated for anthelmintic property, including Veitchia merrillii [7], Curcuma aeruginosa [8], Cymbopogan nardus and Azadirachta indica [9], Nigella sativa [10][11], and many more. Balqis et al [7] explored the use of V. merrillii as anthelmintic drug on Ascaridia galli adult worm, however not much information is available on the use of this plant extract on trematodes, especially on liver flukes F. gigantica.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Veitchia merrillii Extract on Mortality and Tegument Structure of Fasciola gigantica

Vanda¹,

Anwar²,

Ak³

et al. 2021

Advances in Biological Sciences Research

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This study was conducted to explore the effect of methanolic extract of Veithcia merrillii on mortality time and histopathological changes of Fasciola gigantica in vitro. This study used 25 adult flukes of F. gigantica, divided into five groups: C0 as negative control (0.9% PBS), C1 as positive control (0.024mg/ml albendazole), and treatment groups were P1, P2, and P3 used 10%, 25% and 50% extract, respectively. The observation was carried out every 15 minutes to monitor the motility and mortality of each treatment group. Mortality time of each group was determined by score index and analyzed descriptively. Dead flukes from each group were then prepared for histological examination. The results revealed that 50% of V. merrillii extract (P3) had the same mortality time as C1, where all the flukes died after 30 minutes of treatment. Group P2 had a longer mortality time at 45 minutes and P1 was at 75 minutes. Histopathological observation showed alteration on some organs for C1 and treatment groups, including separation of flukes tegument from parenchyma, vacuolization, and disintegration of testis. From the results it can be concluded that methanolic extract of V. merrillii at 25% and 50% concentration was effective as anthelmintic on F. gigantica in vitro.

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“…Due to this condition, C. aeruginosa has many vernacular names, a common informal name given by each origin where the plant grows. C. aeruginosa Roxb is usually known as Temu Hitam [25][26], Temu ireng [27], Kathali holud [9], Khamin-dam [6], Wanmahamek [6,24], Pink and blue ginger [7], Mahamek [28], Black Tumeric [29], Gajutsu [5], Kajeawdang [30], and Kali haldi [8,10].…”

Section: Vernacular Namementioning

confidence: 99%

Phytochemistry and Biological Activities of Curcuma aeruginosa (Roxb.)

Sari

Supratman

2022

Indones. J. Chem.

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Curcuma aeruginosa Roxb. is a stemless, aromatic rhizomatous plant, generally characterized by red corolla lobes, purple calyx, dark purple leaf sheath, purple-brown midrib, and greenish-blue rhizome. This species is usually blooming during the wet and rainy seasons, while the rhizome and leaves have an aromatic odor indicating the presence of volatile constituents. This plant has been used in many traditional medicines as a disinfectant, expectorant, and tonic, including treatment for the wound, diarrhea, dysmenorrhea, fever, coughs, and asthma. This paper aims to provide C. aeruginosa Roxb., summarized data regarding traditional uses, ethnopharmacology, phytochemistry, and pharmacological activities. From 1987 to 2021, about 34 phytochemicals have been isolated, and up to 223 compounds have been detected using Gas Chromatography-Mass Spectrometry. These metabolites differ from flavonoids, terpenoids, steroids, phenanthrenes, and so forth. Furthermore, various investigations demonstrated that the extracts and compounds obtained from the plant possess several pharmacological activities such as anticancer, antioxidant, antimicrobial, anti-dengue, immunostimulant, anthelmintic, anti-inflammatory, antiandrogenic, anti-nociceptive, and antipyretic, as well as uterine relaxant effect. Curcuma aeruginosa Roxb. is a promising medicinal herb and is usually used as oriental traditional medicine by local folks. Therefore, the result supports this plant as a potential source for therapeutic applications and drug development prospects.

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Anthelmintic Activity of Curcuma Aeruginosa Roxb Extract on Fasciola gigantica in Vitro

Cited by 6 publications

References 8 publications

Pathological Changes of Fasciola gigantica After Treatment with Nigella sativa in Vitro

Pathological Changes of Fasciola gigantica After Treatment with Nigella sativa in Vitro

Effect of Veitchia merrillii Extract on Mortality and Tegument Structure of Fasciola gigantica

Phytochemistry and Biological Activities of <i>Curcuma aeruginosa</i> (Roxb.)

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