Anthelmintic activity of essential oil of Ocimum sanctum and eugenol

Asha, M.K.; D’Souza, Paschal; Murali, B.; Agarwal, Amit

doi:10.1016/s0367-326x(01)00270-2

Cited by 112 publications

(66 citation statements)

References 3 publications

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“…The result of the present in vitro evaluation of geraniol against Contracaecum sp confirms the anthelminthic action of this compound, emphasizing the need for future in vivo tests for the use of this compound in the treatment of human and animal anisakiasis. The use of other monoterpene compounds has been investigated, such as eugenol against Caenorhabiditis elegans (20), showing a larvicidal effect with an ED 50 of 62.1 μg/mL. Other investigators evaluated the effect of eugenol against Anisakis simplex larvae but did not obtain a larvicidal effect at the maximum concentration tested of 12.5 μg/mL (13).…”

Section: Discussionmentioning

confidence: 99%

In vitro larvicidal activity of geraniol and citronellal against Contracaecum sp (Nematoda: Anisakidae)

Barros

Yamanaka

Silva

et al. 2009

Braz J Med Biol Res

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Section: Discussionmentioning

confidence: 99%

In vitro larvicidal activity of geraniol and citronellal against Contracaecum sp (Nematoda: Anisakidae)

Barros

Yamanaka

Silva

et al. 2009

Braz J Med Biol Res

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“…The antiproliferative activity of EU against melanoma (Ghosh et al, 2005), leukemia (Jaganathan et al, 2011), gastric (Benencia and Courreges, 2000), skin tumor (Chogo and Crank, 1981) and prostate cancer (Asha et al, 2001) cells has been confirmed by many researchers.…”

Section: Apoptotic Effects Of Eugenol-loaded Nanoemulsions In Human Cmentioning

confidence: 90%

Apoptotic Effects of Eugenol-loaded Nanoemulsions in Human Colon and Liver Cancer Cell Lines

Majeed¹,

Antoniou²,

Zhong³

2014

Asian Pacific Journal of Cancer Prevention

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Background: In this study eugenol (EU) loaded nanoemulsions (NEs) emulsified with modified starch were prepared and their apoptotic potential against liver and colon cancer cells was examined in comparison with bulk EU. Materials and Methods: We prepared stable EU loaded NEs whcih were characterized by dynamic light scattering, centrifugation and gas chromatography. Furthermore, cell viability was determined using MTT assay, and apoptosis and cell cycle analysess by flow cytometry. Results: HB8065 (liver) and HTB37 (colon) cells when treated with EU:CA NEs demonstrated greater apoptotic cells percentages as evidenced by microscopic images and flow cytometric evaluations. It was observed that EU and EU:CA NE induced apoptosis in both cell lines via reactive oxygen species (ROS) generation. Conclusions: The present study demonstrated that ROS plays a critical role in EU and EU:CA NE induced apoptosis in HB8065 and HTB37 cells. This is the first report on the antiproliferative mechanisms of EU loaded NE.

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“…It has been reported that EU is a phenolic compound that induces apoptosis in human colon cancer cells [16]. The antiproliferative activity of EU against melanoma [17], leukemia [18], gastric [19], skin tumor [20], and prostate cancer [21] cells has been confirmed by many researchers. Structure of phenylprepanoids, eugenol scaffold and its derivatives as anticancer as Fig.…”

Section: Introductionmentioning

confidence: 90%

Phenylpropanoids, Eugenol Scaffold, and Its Derivatives as Anticancer

Fadilah

Yanuar²,

Arsianti³

et al. 2017

Asian J Pharm Clin Res

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Eugenol (EU) is a phenylpropene, an allyl chain-substituted guaiacol. EU is a member of the phenylpropanoids class of chemical compounds. It is a colorless to pale yellow oily liquid extracted from certain essential oils especially from clove oil. Further, chemopreventive agents might be used singly or in combination with chemotherapy or radiotherapy for the more effective treatment of cancer by enhancing the efficacy of these modalities with minimal side effects and toxicity. Considering that EU scaffold may be a prospective chemopreventive agent, its potent antitumor ability to interfere with solid cancer cell growth and its molecular mechanism were evaluated as an initiative toward the development of a novel strategy for cancer treatment. This review article will conduct that EU as the antiproliferative activity and molecular mechanism of the EU induced apoptosis against the cancer cells and animal models.

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Anthelmintic activity of essential oil of Ocimum sanctum and eugenol

Cited by 112 publications

References 3 publications

In vitro larvicidal activity of geraniol and citronellal against Contracaecum sp (Nematoda: Anisakidae)

In vitro larvicidal activity of geraniol and citronellal against Contracaecum sp (Nematoda: Anisakidae)

Apoptotic Effects of Eugenol-loaded Nanoemulsions in Human Colon and Liver Cancer Cell Lines

Phenylpropanoids, Eugenol Scaffold, and Its Derivatives as Anticancer

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