Anthelmintic activity of Cratyliamollis leaves against gastrointestinal nematodes in goats

Abstract

SUMMARY The present study assessed the in vivo anthelmintic activity of the C. mollis leaf decoction extract when administered orally to naturally infected goats with gastrointestinal nematodes. To this, animals were randomized into three groups:non-treated, control (treated with doramectin 1mL/50 kg b.w.) and C. mollis extract treated groups (2.5mg/kg b.w.). Blood and faecal samples were collected from each animal at day 0, and 30th day posttreatment to monitor immunological and parasitological parameters. A significant faecal egg reduction (61.1%) and an increase in IgA and eosinophils levels were observed in the C. mollis extract treated group, in comparison to the untreated and doramectin groups. Considering that gastrointestinal nematode infections in small ruminants are serious problems in the world, causing economic losses worldwide, associated to high anthelmintic cost, resistance to available anthelmintics and residue problems in meat and milk for human consumption, the plant extract use is an area of interest to search new anthelmintic agents. Thus, Cratyliamollis Mart. Ex Benth, an important medicinal plant from Brazilian Northeast semiarid region, is used to treat different types of diseases, and as forage supplementation. Therefore, the data indicated the potential anthelmintic activity of C. mollis extract; further research is thereby warranted to assess its value for therapeutic purposes.

In Vivo Anthelminthic Activity of <i>Ceratotheca sesamoïdes</i> Endl Whole Plant Powder

“…Similarly, to our study, Vitex thomasii bark powder administered to naturally infested goats did not result in a significant difference in weight evolution during 126 days of follow-up [29]. Aqueous extracts of Cratylia mollis administered to goats naturally infested with NGIs did not result in a significant difference in ADG of the animals after 30 days of follow-up which corroborates to our study although the species of animals are different with our study [23]. The whole plant powder of C. sesamoïdes caused an improvement in hematocrit level between D0 (27.66) and D21 (30.5) at the dose of 14g/kg body weight while the mean hematocrit level of the batch treated with 7g/kg body weight decreased slightly between D0 (27.33) and D21 (26.66) but no significant difference was revealed.…”

Effectiveness of Cratylia argentea as an animal feed supplement in the control of gastrointestinal nematodes in sheep

“…In addition to its nutritional qualities, the anthelmintic effects of Cratylia spp. have been reported empirically by producers of small ruminants in the interior of Brazil (ALBUQUERQUE et al, 2007), and by researchers in vitro (MENDONÇA-LIMA et al, 2016;MENEZES et al, 1991;SILVA et al, 2017). Thus, the aim of the present work was to evaluate for the first time the in vivo effectiveness of C. argentea on gastrointestinal nematodes of sheep in a "protein bank" type management system.…”