Anthelmintic 2-(5-nitro-2-thienyl)-4-(substituted amino)quinazolines

2-(4-Chlorophenyl)-3-{[(1E)-(4-chlorophenyl)methylene]amino}-2,3-dihydroquinazolin-4(1H)-one

“…For related structures, see: Shi et al (2004aShi et al ( , 2004b; Shi, Li, Shi, Zhuang & Zhang (2004); ; Vembu et al (2006); Swamy & Ravikumar (2005); Chruszcz et al (2007). For related literature, see: Hodnett & Dunn (1970); Alaimo & Russel (1972); Alaimo & Hatton (1972); Cremer & Pople (1975); Misra et al (1981); Varma et al (1986); Singh & Dash (1988); Pandey et al (1999); El-Masry et al (2000); Desai et al (2001); Birch et al (2005). T min = 0.926, T max = 1.000 (expected range = 0.885-0.955) 16112 measured reflections 6303 independent reflections 2674 reflections with I > 2(I) .63 6303 reflections 252 parameters H atoms treated by a mixture of independent and constrained refinement Á max = 0.42 e Å À3 Á min = À0.40 e Å À3 Table 1 Hydrogen-bond geometry (Å , ).…”

“…Substituted 2,3-dihydroquinazolin-4(1H)-ones are found to be potent inhibitors of inosine 5′-monophosphate dehydrogenase type II (Birch et al, 2005) and also are found to possess antibacterial (Alaimo & Russel, 1972) and anthelmentic activities (Alaimo & Hatton, 1972). Schiff bases are used as substrates in the preparation of number of industrial and biologically active compounds via ring closure, cycloaddition and replacement reactions.…”

Progress in the Experimental Chemotherapy of Helminth Infections; Part I, Trematode and Cestode Infections

“…nana [314], while 4-[(2-hydroxyethyl)amino]-2-(5-nitro-2-thienyl)quinazoline (CXLVII), the most active of a series of nematocidal nitrothienylquinazolines, was reported to cause a 100% reduction in Hymenolepis nana in mice when administered at 25 mg/kg twice a day for 3 days [315]. In addition to some in vitro antiprotozoal activity, nitro-derivatives of arylsydnones CXL VIII were effective against H. nana in mice, showing taenicidal activity only a little inferior to that of quinacrine [316].…”

Synthesis and Antimicrobial Activity of 2-Substituted-3-((3-(6-Nitrobenzo[D]thiazol-2-yl)-4-oxo-3,4-Dihydroquinazolin-2-yl)Methyl)-1,3,4-thiadiazol-3-ium-5-thiolate

“…8 1,3,4-thiadiazolium-2-thiolates, being isoelectronic with Sydnone, 9 have also been widely reported for their biological activities. [10][11][12] Quinazolinones are important class of fused heterocycles that are of considerable interest on account of diverse range of their biological activities 13 like antihypertensive, 14 CNS depressants, 15 analgesic, 16 anti-histamine, 17,18 biofungicide, diuretic properties protein tyrosine, antihypertens, 19 antifolates inhibitor, 20,21 anticancer, 22 antidepressant, anthelmintic agent, 23 antiprion agent, 24 antibacterial, 25,26 cholecystokinin inhibitor, antimalarial activity, 27 antiallergic, antifungal, 28 antitumor, 29 antiproliferative activity, 30 anticonvulsant, 31 anti-HIV, 32,33 antagonists, [34][35][36] and several other useful and interesting properties. 37 Quinazolinones showed potent cytotoxic activity 38 against Human Gllioblasion Cells.…”