Anterior uveitis onset after bnt162b2 vaccination: is this just a coincidence?

Renisi, Giulia; Lombardi, Andrea; Stanzione, Massimo; Invernizzi, Alessandro; Bandera, Alessandra; Gori, Andrea

doi:10.1016/j.ijid.2021.07.035

Cited by 66 publications

(56 citation statements)

References 11 publications

(5 reference statements)

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“… 1 Ocular involvement after vaccination is rare and a few reported cases have been recently published after COVID-19 vaccination. 2 , 3 , 4 The development of new imaging technologies in ophthalmology, such as optical coherence tomography (OCT), has significantly changed the understanding, diagnosis, and management of many ocular diseases, including those resulting from posterior uveitis. 5 …”

Section: Introductionmentioning

confidence: 99%

Bilateral acute macular neuroretinopathy in a young woman after the first dose of Oxford–AstraZeneca COVID-19 vaccine

Gabrielle

Baudin

Ghezala

et al. 2022

American Journal of Ophthalmology Case Reports

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Purpose To report a case of bilateral acute macular neuroretinopathy following the first dose of Oxford-AstraZeneca COVID-19 (coronavirus disease 2019) vaccine in a young, Caucasian, and healthy woman. Observations A 25-year-old Caucasian female patient presented to the ophthalmology department of Dijon University Hospital with a 3-week history of black spots and paracentral scotoma in both eyes. She had no past medical history and was using the combined estrogen-progestin oral contraceptive (COC). These symptoms occurred 24 h after receiving the first Oxford-AstraZeneca COVID-19 vaccination dose. The ophthalmologic signs were preceded a few hours earlier by fever and flu-like symptoms. Ophthalmologic examination revealed a preserved visual acuity with a quiet anterior segment and normal fundus in both eyes. Findings on multimodal retinal imaging, particularly near-infrared reflectance (NIR) and optical coherence tomography (OCT) imaging, were classical of an acute macular neuroretinopathy in both eyes. Conclusions and importance: COVID-19 vaccination is justified as an essential public health measure. Acute macular neuroretinopathy may occur in patient receiving a COVID-19 vaccination dose. Further reports are needed to confirm this association. Physicians should be aware of this complication and request an eye examination with at least OCT or NIR imaging in the case of any visual symptoms after vaccination, notably in young women using COC.

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Section: Introductionmentioning

confidence: 99%

Bilateral acute macular neuroretinopathy in a young woman after the first dose of Oxford–AstraZeneca COVID-19 vaccine

Gabrielle

Baudin

Ghezala

et al. 2022

American Journal of Ophthalmology Case Reports

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“…The literature of COVID-19 vaccines-related uveitis was rare. Renisi et al reported a case of anterior uveitis 14 days after the second dose of BNT162b2 COVID ( 8 ). The precise pathogenesis frequently remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Associated Ocular Adverse Reactions With Inactivated COVID-19 Vaccine in China

et al. 2022

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The vaccine is still the best clinical measure for effective prevention and control of coronavirus disease 2019 (COVID-19). The vaccine-associated ocular adverse reactions should be noted in detail among the medical community. We reported twelve eyes of 9 patients presented at the Department of Ophthalmology, Qilu Hospital of Shandong University from March to August 2021 with ocular complaints following COVID-19 vaccination. The main inclusion criterion was the development of ocular symptoms within 14 days after receiving a dose of an inactivated COVID-19 vaccine. The mean (SD) age was 44.7 ± 16.5 years (range, 19–78 years), among which seven (77.8%) cases were women. The mean time of ocular adverse events was 7.1 days (range, 1–14 days) after receiving the inactivated COVID-19 vaccine. One patient was diagnosed with choroiditis, 1 with uveitis, 4 with keratitis, 1 with scleritis, 1 with acute retinal necrosis, and 1 with iridocyclitis. Although the causal relationship between vaccines and ocular adverse events cannot be established from this case series report, physicians should pay attention to the ocular adverse reactions following the COVID-19 vaccine administration.

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“…It has been speculated that mRNA vaccines induce strong activation of the cellular and humoral immune responses, resulting in molecular mimicry that may lead to immune cross-reactivity, triggering an autoimmune disease like anterior uveitis. 13 The original uveitis and its recurrence were relatively unusual and severe for uveitis as is the association with CRVO and rubeosis. The patient was advised to refrain from the previously scheduled second COVID-19 vaccine shot.…”

Section: Discussionmentioning

confidence: 99%

Anterior uveitis onset after bnt162b2 vaccination: is this just a coincidence?

Cited by 66 publications

References 11 publications

Bilateral acute macular neuroretinopathy in a young woman after the first dose of Oxford–AstraZeneca COVID-19 vaccine

Bilateral acute macular neuroretinopathy in a young woman after the first dose of Oxford–AstraZeneca COVID-19 vaccine

Case Report: Associated Ocular Adverse Reactions With Inactivated COVID-19 Vaccine in China

Severe panuveitis with iridis rubeosis activation and cystoid macular edema after BioNTech-Pfizer COVID-19 vaccination in a 17-year-old

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