Anterior Uveitis and Diabetes mellitus: Immunological Study

Abstract

The association between anterior uveitis (AU) and diabetes mellitus (DM) has always been known. The purpose of this study was to estimate the incidence of this association and to consider a possible role ofthe cell-mediated immune system. During the years 1989–1992, 196 diabetics (66 patients affected by type I DM and 130 by type II DM) were studied. The study ofthe lymphocytic subsets and the measurement of the circulating immunocomplexes and autoantibodies (ANA, AMA, ADNA, ASMA, APCA) were carried out, and the results were compared with those of a control group. The results underline the correlation between AU and type I DM. Many immunological reactions could play a crucial role: the high levels of CD8 subsets found could be an expression ofthe unstable lymphocytic equilibrium.

Exacerbation of autoimmune uveitis by obesity occurs through the melanocortin 5 receptor

“…There have been reports that diabetic retinopathy can exacerbate uveitis and uveitis can accelerate diabetic retinopathy . While the HFD model we used only achieved moderate diabetes, it did exacerbate the uveitis.…”

Patterns of Uveitis among Nepalese population Presenting at a Tertiary Referral Eye Care Centre in Nepal

“…In our study there were 177 patient (3.69%) of anterior uveitis who had diabetes included under metabolic disorder. DM associated uveitis has been reported as rare disease and its pathophysiology has been attributed to immunological causes [41][42][43]. It is not certain whether our patients with medical history of DM accidentally suffered from idiopathic uveitis or if DM was the direct cause of uveitis Glycaemic improvements may prevent recurrence [44].…”

Glaucoma neovascular e esclerite necrosante com inflamação. Há uma relação?

“…(10) Níveis aumentados de TNF-α e MMP-9 foram detectados em lágrimas de pacientes com esclerite necrosante. (10) Castagna et al (11) e Ansari et al (12) encontraram uma associação significativa entre uveíte anterior e DM1. Essa relação entre diabetes mellitus e inflamação ocular é atribuída à disfunção da barreira hemato-ocular, o que inclui o aumento de fatores pró-inflamatórios como IL-1, IL-6, IL-8, proteína 10 induzida por interferon e TNF-α na RD.…”