Anterior Uveitis After Treatment of Hepatitis C with Alpha Interferon: The Recurrence of a Previous Inflammatory Process due to Presumed Ocular Toxocariasis

Damasceno, Eduardo de França; Damasceno, Nadyr A

doi:10.3109/09273948.2011.615448

Cited by 6 publications

(2 citation statements)

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“…Symptomatic disease manifestations depend on the infection intensity, the duration of migration, the organs involved, and immune-and age-mediated host responses (20). Currently, both pediatric and adult patients with toxocariasis report a wide variety of inflammation-related conditions, such as asthma, pneumonia, lymphadenopathy, endomyocarditis, granulomatous hepatitis, generalized endophthalmitis, meningoencephalitis, and cutaneous manifestations (33,(62)(63)(64)(65)(66)(67)(68)(69). Notably, the focus of much research has been on the role of T. canis in neuropathological disorders, particularly epilepsy (70)(71)(72)(73).…”

Section: Types Of Human Toxocariasis and Immunopathogenesismentioning

confidence: 99%

Cerebral Toxocariasis: Silent Progression to Neurodegenerative Disorders?

et al. 2015

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SUMMARY Toxocara canis and T. cati are highly prevalent nematode infections of the intestines of dogs and cats. In paratenic hosts, larvae do not mature in the intestine but instead migrate through the somatic tissues and organs of the body. The presence of these migrating larvae can contribute to pathology. Toxocara larvae can invade the brains of humans, and while case descriptions of cerebral toxocariasis are historically rare, improved diagnosis and greater awareness have contributed to increased detection. Despite this, cerebral or neurological toxocariasis (NT) remains a poorly understood phenomenon. Furthermore, our understanding of cognitive deficits due to toxocariasis in human populations remains particularly deficient. Recent data describe an enhanced expression of biomarkers associated with brain injury, such as GFAP, AβPP, transforming growth factor β1 (TGF-β1), NF-L, S100B, tTG, and p-tau, in mice receiving even low doses of Toxocara ova. Finally, this review outlines a hypothesis to explore the relationship between the presence of T. canis larvae in the brain and the progression of Alzheimer's disease (AD) due to enhanced AD-associated neurodegenerative biomarker expression.

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Section: Types Of Human Toxocariasis and Immunopathogenesismentioning

confidence: 99%

Cerebral Toxocariasis: Silent Progression to Neurodegenerative Disorders?

et al. 2015

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“…The most common of these are retinal vein occlusion (RVO) [21,29,30,32,[49][50][51][52][53][54][55] , and non-arteritic anterior ischemic optic neuropathy (NAION) [28,49,[56][57][58][59] . Other atypical adverse events that have been reported include ocular myasthenia [60,61] , optic neuritis [62] , Vogt-Koyanagi-Harada disease [49,[63][64][65][66][67] , ocular sarcoidosis [68,69] , ocular toxocariasis [70] , neurovascular glaucoma [71] , conjunctival hemorrhage [20,26,35] , macular edema [72][73][74] , oculomotor nerve palsy [75] , trichomegaly [23] and retinal detachment [76] .…”

Section: Atypical Adverse Eventsmentioning

confidence: 99%

Ophthalmologic complications of antiviral therapy in hepatitis C treatment

O’Day

Gillies

Ahlenstiel

2013

WJG

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Antiviral therapy consisting of interferon-alpha and ribavirin for chronic hepatitis C infection is associated with multi-system side-effects. Ophthalmologic complications are common and can be classified into two groups: interferon-associated retinopathy and atypical adverse events. Interferon-associated retinopathy has been investigated by multiple observational studies that have found widely divergent results. The clinical importance of this complication is, consequently, controversial. This review examines the literature with the specific goal of identifying the most important ophthalmologic issues facing the hepatologist prescribing antiviral therapy. Accordingly, it assesses the incidence of interferon-associated retinopathy, as well as its risk factors, pathogenesis, clinical manifestations and options for management using data from the observational studies. The likely benefit of a screening program, especially one targeting patients with the highest risk of developing interferon-associated retinopathy, is analysed. Atypical ophthalmologic adverse events occur less frequently than interferon-associated retinopathy during antiviral therapy for chronic hepatitis C infection. They often, however, lead to irreversible vision loss. We examine the reports of these adverse events - in individual case reports or case series and in the observational studies investigating interferon-associated retinopathy - to describe the spectrum of these adverse events, the likely outcome for patients and to highlight the most important areas of future clinical research.

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Drug-induced ocular side effects

2015

Drug-Induced Ocular Side Effects

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Anterior Uveitis After Treatment of Hepatitis C with Alpha Interferon: The Recurrence of a Previous Inflammatory Process due to Presumed Ocular Toxocariasis

Abstract: immunostimulation could cause a relapse of the inflammatory reaction found in uveitis due to toxocariasis.

Cited by 6 publications

References 3 publications

Cerebral Toxocariasis: Silent Progression to Neurodegenerative Disorders?

Cerebral Toxocariasis: Silent Progression to Neurodegenerative Disorders?

Ophthalmologic complications of antiviral therapy in hepatitis C treatment

Drug-induced ocular side effects

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