Anterior thalamic radiation structural and metabolic changes in obsessive-compulsive disorder: A combined DTI-MRS study

Fan, Qing; Zhang, Zongfeng; Chen, Yongjun; Zhu, Yajing; Li, Yao

doi:10.1016/j.pscychresns.2018.05.004

Cited by 12 publications

(9 citation statements)

References 40 publications

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“…Two studies that combined DTI and MRS targeting the dorsal ACC and anterior thalamic radiation (ATR) found positive correlation between choline levels and FA in dorsal ACC and negative correlation between choline levels and fiber length in the right ATR[5051] as shown in Table 4. In addition, FA in the ACC and right ATR correlated with Y-BOCS symptom severity.…”

Section: Magnetic Resonance Spectroscopymentioning

confidence: 99%

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Neuroimaging findings in obsessive–compulsive disorder: A narrative review to elucidate neurobiological underpinnings

Hazari

Narayanaswamy

Venkatasubramanian

2019

Indian J Psychiatry

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Obsessive compulsive disorder (OCD) is a common psychiatric illness and significant research has been ongoing to understand its neurobiological basis. Neuroimaging studies right from the 1980s have revealed significant differences between OCD patients and healthy controls. Initial imaging findings showing hyperactivity in the prefrontal cortex (mainly orbitofrontal cortex), anterior cingulate cortex and caudate nucleus led to the postulation of the cortico-striato-thalamo-cortical (CSTC) model for the neurobiology of OCD. However, in the last two decades emerging evidence suggests the involvement of widespread associative networks, including regions of the parietal cortex, limbic areas (including amygdala) and cerebellum. This narrative review discusses findings from structural [Magnetic Resonance Imaging (MRI), Diffusion Tensor Imaging(DTI)], functional [(functional MRI (fMRI), Single photon emission computed tomography (SPECT), Positron emission tomography (PET), functional near-infrared spectroscopy (fNIRS)], combined structural and functional imaging studies and meta-analyses. Subsequently, we collate these findings to describe the neurobiology of OCD including CSTC circuit, limbic system, parietal cortex, cerebellum, default mode network and salience network. In future, neuroimaging may emerge as a valuable tool for personalised medicine in OCD treatment.

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Section: Magnetic Resonance Spectroscopymentioning

confidence: 99%

“…In addition, FA in the ACC and right ATR correlated with Y-BOCS symptom severity. [5051] The summary of combined structural and functional imaging studies (DTI + MRS) is shown in Table 4.…”

Section: Magnetic Resonance Spectroscopymentioning

confidence: 99%

Neuroimaging findings in obsessive–compulsive disorder: A narrative review to elucidate neurobiological underpinnings

Hazari

Narayanaswamy

Venkatasubramanian

2019

Indian J Psychiatry

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“…In healthy adults, WM NAA explained a significant proportion of variability in the FA values, particularly in the splenium of corpus callosum (Wijtenburg et al, 2013). Although a handful of studies have attempted to correlate WM integrity to H1-MRS profile in schizophrenia (Steel et al, 2001; Tang et al, 2007; Rowland et al, 2009; Chiappelli et al, 2015; Reid et al, 2016), the relationship between WM integrity and brain biochemistry in OCD patients remains understudied (Wang et al, 2017, 2018). In the first combined DTI-MRS study, Wang et al found a positive correlation between FA in the dorsal ACC and choline.…”

Section: Introductionmentioning

confidence: 99%

An MRI Study of the Metabolic and Structural Abnormalities in Obsessive-Compulsive Disorder

Andrade

Ferreira

Suo

et al. 2019

Front. Hum. Neurosci.

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Obsessive-compulsive disorder (OCD) is a neuropsychiatric illness characterized by obsessions and/or compulsions. Its pathophysiology is still not well understood but it is known that the cortico-striatal-thalamic-cortical (CSTC) circuitry plays an important role. Here, we used a multi-method MRI approach combining proton magnetic resonance spectroscopy (H1-MRS) and diffusion tensor imaging (DTI) techniques to investigate both the metabolic and the microstructural white matter (WM) changes of the anterior cingulate cortex (ACC) in OCD patients as compared to healthy controls. Twenty-three OCD patients and 21 age-, sex-, and education-matched healthy volunteers participated in the study. Our 1H-MRS findings show increased levels of Glx in ACC in OCD. Further, significantly lower fractional anisotropy (FA) values were observed in OCD patients’ left cingulate bundle (CB) as compared to healthy controls. Finally, there was a negative correlation between FA in the left CB and level of obsessions, as well as the duration of the illness. Our findings reinforce the involvement of CSTC bundles in pathophysiology of OCD, pointing to a specific role of glutamate (glutamine) and WM integrity.

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“…Abnormalities in other white matter tracts have also been reported in OCD. Abnormal (decreased or increased) FA has been reported in the genu [20, 26, 27], body [28, 29], and splenium [27, 30] of the corpus callosum and/or anterior projecting fibers, including the anterior corona radiata, anterior thalamic radiation, and/or anterior limb of the internal capsule [21, 25, 31, 32]. These findings are less consistent across studies than those regarding the cingulum bundle, however.…”

Section: Introductionmentioning

confidence: 99%

Reduced focal fiber collinearity in the cingulum bundle in adults with obsessive-compulsive disorder

Versace

Graur

Greenberg

et al. 2019

Neuropsychopharmacol.

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Obsessive-compulsive disorder (OCD) is a disabling condition, often associated with a chronic course. Given its role in attentional control, decision-making, and emotional regulation, the anterior cingulate cortex is considered to have a key role in the pathophysiology of the disorder. Notably, the cingulum bundle, being the major white matter tract connecting to this region, has been historically a target for the surgical treatment of intractable OCD. In this study, we aimed to identify the extent to which focal—more than diffuse—abnormalities in fiber collinearity of the cingulum bundle could distinguish 48 adults with OCD (mean age [SD] = 23.3 [4.5] years; F/M = 30/18) from 45 age- and sex-matched healthy control adults (CONT; mean age [SD] = 23.2 [3.8] years; F/M = 28/17) and further examine if these abnormalities correlated with symptom severity. Use of tract-profiles rather than a conventional diffusion imaging approach allowed us to characterize white matter microstructural properties along (100 segments), as opposed to averaging these measures across, the entire tract. To account for these 100 different segments of the cingulum bundle, a repeated measures analysis of variance revealed a main effect of group (OCD < CONT; F[1,87] = 5.3; P = 0.024) upon fractional anisotropy (FA, a measure of fiber collinearity and/or white matter integrity), in the cingulum bundle, bilaterally. Further analyses revealed that these abnormalities were focal (middle portion) within the left and right cingulum bundle, although did not correlate with symptom severity in OCD. Findings indicate that focal abnormalities in connectivity between the anterior cingulate cortex and other prefrontal cortical regions may represent neural mechanisms of OCD.

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Anterior thalamic radiation structural and metabolic changes in obsessive-compulsive disorder: A combined DTI-MRS study

Cited by 12 publications

References 40 publications

Neuroimaging findings in obsessive–compulsive disorder: A narrative review to elucidate neurobiological underpinnings

Neuroimaging findings in obsessive–compulsive disorder: A narrative review to elucidate neurobiological underpinnings

An MRI Study of the Metabolic and Structural Abnormalities in Obsessive-Compulsive Disorder

Reduced focal fiber collinearity in the cingulum bundle in adults with obsessive-compulsive disorder

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