Anterior Segment Optical Coherence Tomography for Imaging the Sub-Tenon Space

Kumar, Dhivya Ashok; Agarwal, Amar; Karnathi, Saraswathy; Patadiya, Rasik

doi:10.1159/000354381

Cited by 7 publications

(5 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean thickness of the anterior Tenon's capsule in this previous study was 0.21 6 0.07 mm. In Figure 2 of the Kumar et al 5 study, Tenon's capsule showed a similar reflectance with splitting fibers similar to the findings for the Tenon's capsule in the posterior segment in our current study.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Optical Coherence Tomographic Imaging of Posterior Episclera and Tenon's Capsule

Ohno‐Matsui

Fang

Morohoshi

et al. 2017

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 91%

“…2A, 2C, 2E). Using highspeed anterior segment OCT, Kumar et al 5 examined the anterior Tenon's capsule in 12 eyes which received a drug injection into the posterior sub-Tenon space for the therapy of uveitis. The mean thickness of the anterior Tenon's capsule in this previous study was 0.21 6 0.07 mm.…”

Section: Discussionmentioning

confidence: 99%

Optical Coherence Tomographic Imaging of Posterior Episclera and Tenon's Capsule

Ohno‐Matsui

Fang

Morohoshi

et al. 2017

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…Firstly, higher CP concentration at the delivery site could be obtained via SMS due to slower clearance rate. It has been shown that the vascular density is low in sub-Tenon’s area, 33 which can decrease drug clearance by blood flow. Furthermore, the concentration gradient can enhance drug penetration from the scleral surface to the retina/vitreous.…”

Section: Discussionmentioning

confidence: 99%

“…Firstly, higher CP concentration at the delivery site could be obtained via SMS due to slower clearance rate. It has been shown that the vascular density is low in sub-Tenon's area, 33 which can decrease drug clearance by blood flow. Furthermore, the concentration gradient can enhance drug penetration from the scleral surface to the retina/vitreous.- [34][35][36] Thus, the longer period for CP loading at the injection site, the higher possibility for CP penetrating into the sclera and getting to the ocular tissue.…”

Section: Discussionmentioning

confidence: 99%

<p>Efficacy of Sub-Tenon Micro-Perfusion of Cyclophosphamide in Rabbits with Severe Ocular Inflammation</p>

Zhao

Peng

Lin

et al. 2020

DDDT

View full text Add to dashboard Cite

Purpose To explore the feasibility of cyclophosphamide (CP) via a sub-Tenon micro-perfusion system (SMS) in rabbits, and assess its therapeutic efficacy in severe ocular inflammation. Materials and Methods Distribution and pharmacokinetics of CP were evaluated in vivo, and the concentrations of CP in plasma, vitreous humor, and retina/choroid were quantitated by ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) at different time points. After induction of severe experimental uveitis, rabbits were divided into three groups (n=8 in each): the SMS group, subconjunctival injection (SI) group, and control group. Clinical inflammatory score was assessed in rabbits. Electroretinography and histopathology were performed on post-treatment day 8. Statistical analyses were performed using Mann–Whitney and Kruskal–Wallis tests. P -value less than 0.05 was considered significant. Results The concentrations of CP in vitreous humor and retina/choroid in the SMS group were significantly higher than that of the SI group at 3, 6, 10, and 24 hours ( P <0.01), while plasmatic CP concentrations were comparable at all time points in the SMS group and SI group ( P >0.05). The SMS group showed significantly less inflammation compared to the control group and SI group. Furthermore, the restoration of retinal structure and function were more obvious in the SMS group compared with conventional SI application. Conclusion Sub-Tenon micro-perfusion of CP exhibited satisfied therapeutic efficacy in rabbits with severe ocular inflammation and may provide a promising alternative for controlling ocular inflammatory disease and immune-mediated ocular diseases.

show abstract

“…TC has a dense amorphous histological structure and contains broblasts [13][14][15][16][17]. Being one connective tissue, TC heals completely by brosis, [7,14,19,20] compromising its mobility and providing poor TRAB outcomes. Furthermore, the TC adheres only weakly to the episclera, and is separated from it by the STS [20].…”

Section: Introductionmentioning

confidence: 99%

Preservation of the Tenon’s capsule and Sub-Tenon’s space after the autologous limbal-conjunctival transplantation in pterygium surgery

Vidal¹,

Cronemberger²,

Massote³

2021

Preprint

View full text Add to dashboard Cite

Background No previous studies have evaluated the scarring of the conjunctiva and Tenon’s capsule (TC) separately when only the conjunctiva is removed, and TC is preserved in the upper part of the bulb: the site designated for trabeculectomy. Thus, this cohort interventional study aims to investigate the scarring of the donor area after autologous limbal-conjunctival transplantation (ALCT) using anterior segment optical coherence tomography (AS-OCT). Methods Twenty-three eyes with pterygium were submitted to resection and local reconstruction with ALCT. AS-OCT images obtained from each eye preoperatively served as postoperative control. ALCT was removed superiorly with preservation of TC. The cure of this donor area occurred by secondary intention. AS-OCT was performed preoperatively and 30 and 180 days postoperatively in the donor area, measuring the thickness of the conjunctiva (epithelium and stroma) and TC. The sub-Tenon’s space (STS) was clinically assessed. Results The mean thickness of the conjunctival epithelium was 48.04 ± 11.37µm in the preoperative period and 51.87±15.04µm 180 days after surgery, without statistically significant difference (P=0.282). A statistically significant increase (P=0.005) in the mean thickness of the conjunctival stroma, from 85.35±23.10µm in the preoperative period to 101.61±20.19µm 180 days after surgery was found. TC had no significant changes, slightly increasing from 117.13±24.26µm preoperatively to 118.09±19.24µm (P=0.808) 180 days after surgery. STS was found in 19 (82%) eyes 180 days after surgery. Conclusions Following ALCT with TC preservation, scarring took place in the conjunctiva, epithelium, and stroma. The TC and the STS were preserved not showing any significant changes.

show abstract

Anterior Segment Optical Coherence Tomography for Imaging the Sub-Tenon Space

Cited by 7 publications

References 22 publications

Optical Coherence Tomographic Imaging of Posterior Episclera and Tenon's Capsule

Optical Coherence Tomographic Imaging of Posterior Episclera and Tenon's Capsule

<p>Efficacy of Sub-Tenon Micro-Perfusion of Cyclophosphamide in Rabbits with Severe Ocular Inflammation</p>

Preservation of the Tenon’s capsule and Sub-Tenon’s space after the autologous limbal-conjunctival transplantation in pterygium surgery

Contact Info

Product

Resources

About