Anterior Segment Optical Coherence Tomography Parameters in Subtypes of Primary Angle Closure

Guzman, Celeste; Gong, Tianxia; Nongpiur, Monisha E.; Perera, Shamira A.; How, Alicia C.; Lee, Hwee Kuan; Cheng, Li; He, Mingguang; Baskaran, Mani; Aung, Tin

doi:10.1167/iovs.13-12285

Cited by 86 publications

(74 citation statements)

References 22 publications

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“…A recent finding shows that AAC eyes have thicker IT compared with other subgroups of angle closure glaucoma. 9 However, in the study by Sihota et al 22 , AAC eyes had similar IT as PACG eyes, but it was less than that in control eyes. Henzan et al 29 did not find any difference in IT among eyes with PAC, PACS, and controls.…”

Section: Discussionmentioning

confidence: 85%

“…6,7 Iris curvature (I-curve) has been proposed to be an indicator of pupillary block. 8,9 As I-curve is reported to be only moderately correlated with increased LV, pupillary block may not be the only mechanism by which increased LV causes angle closure. 9,10 In fact, there are some cases with exaggerated LV in which the iris appears to drape the anterior surface of the lens, giving rise to a 'volcano-like configuration' without an increase in I-curve.…”

Section: Introductionmentioning

confidence: 99%

“…8,9 As I-curve is reported to be only moderately correlated with increased LV, pupillary block may not be the only mechanism by which increased LV causes angle closure. 9,10 In fact, there are some cases with exaggerated LV in which the iris appears to drape the anterior surface of the lens, giving rise to a 'volcano-like configuration' without an increase in I-curve. 2,11 Exaggerated LV has been defined quantitatively as LV more than one-third the distance between the corneal endothelium and a line drawn to connect the nasal and temporal scleral spurs.…”

Section: Introductionmentioning

confidence: 99%

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Role of lens vault in subtypes of angle closure in Iranian subjects

Moghimi

Vahedian

Zandvakil

et al. 2014

Eye

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Purpose The purpose of this study is to quantify anterior chamber (AC) parameters and to determine the proportion of eyes with exaggerated lens vault (LV) in different subtypes of angle closure disease using anterior segment optical coherence tomography (AS-OCT). Patients and methods In this prospective study, 115 eyes of 115 Iranian patients with angle closure disease were included and categorized into three groups: (1) fellow eyes of acute angle closure (AAC; 40 eyes); (2) primary angle closure glaucoma (PACG; 39 eyes); and (3) primary angle closure suspect (PACS; 36 eyes). Complete ophthalmic examination including gonioscopy, A-scan biometry, and AS-OCT were performed. Angle parameters, LV, and iris thickness (IT) were measured using AS-OCT. An exaggerated LV was defined as LV more than one-third the distance between the corneal endothelium and a line drawn to connect the nasal and temporal scleral spurs. Results Fellow eyes of AAC had the shallower AC (P ¼ 0.01), greater iris curvature (I-curve; P ¼ 0.01), and higher LV (P ¼ 0.02) as compared with PACS and PACG eyes. There was no statistically significant difference in the mean IT at 750 mm from scleral spur among the three groups (P ¼ 0.45). Exaggerated LV was found in 67.5, 35.9, and 40% of fellow eyes of AAC, PACG, and PACS, respectively, (P ¼ 0.008) with an odds ratio of 1.92 (P ¼ 0.005) for fellow vs PACG and 1.68 (P ¼ 0.01) for fellow vs PACS. Conclusions Exaggerated LV is highly prevalent in fellow eyes of AAC. These eyes have shallower AC depth, greater I-curve, and higher LV when compared with PACG and PACS.

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of lens vault in subtypes of angle closure in Iranian subjects

Moghimi

Vahedian

Zandvakil

et al. 2014

Eye

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“…For example, Foo et al [10] performed a linear regression modeling with trabecular-iris space area at 750 μm (TISA 750 ) and angle opening distance at 750 μm (AOD 750 ) from the scleral spur as the two dependent angle width variables; whereas Guzman et al [11] even identified that the TISA 750 is one of the major determinants of acute angle closure.…”

Section: Discussionmentioning

confidence: 99%

Anterior Segment Parameters Associated to Acute Glaucoma with Slit Lamp Optical Coherence Tomography

Argones¹,

Díaz²,

Deustua³

et al. 2014

OJOph

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The acute primary angle closure is an ophthalmological urgency which requires immediate treatment to prevent permanent damaged.The population studies reveal that more than a half of predispose individuals will not manifest the disease. This reality, the cost of laser prophylactic treatment, the risk of ocular complications and the low accessibility to the technology in some populations justify that proper investigations go on to define the morphological and/or functional factors that determine the acute presentation of the disease [1].The optical coherence tomography is a high resolution, non invasive technology that offers the possibility to

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“…[12][13] Chen et al 14 found significant correlation between decreasing ACD and increasing risk of PAC (odds ratio ¼ 3.59 for 0.2 mm decrease in ACD). Therefore, attention should be paid to CLR and ACD, in addition to the parameters specific to the angle itself when monitoring patients with MPS.…”

Section: Anterior Chamber and Angle Morphologymentioning

confidence: 99%

Anterior segment OCT imaging in mucopolysaccharidoses type I, II, and VI

Ahmed

Turnbull

Attridge

et al. 2014

Eye

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Purpose To describe the anterior segment optical coherence tomography (AS-OCT) characteristics of patients with ocular manifestations of mucopolysaccharidoses type I (Hurler), II (Hunter), and VI (Maroteaux-Lamy). Methods Prospective, observational study of nine consecutive patients with variants of mucopolysaccharidosis (MPS) attending the Paediatric Ophthalmology service at Manchester Royal Eye Hospital, UK. All patients underwent Visante AS-OCT imaging as part of their ophthalmic assessment. Results Ocular involvement tended to be symmetrical. Angle-to-angle distance was significantly lower in MPS VI than in MPS I (P ¼ 0.04). Anterior chamber depth, angle opening distance, trabecular-iris space area, and scleral spur angle tended to be lower in MPS VI than in MPS I, but did not reach statistical significance. Corneal thickness in the central 0-2 mm zone was greater in MPS VI than in MPS I, approaching but not attaining statistical significance (P ¼ 0.07). The 2-5 and 5-7 mm zones were significantly thicker in MPS VI than MPS I (P ¼ 0.04, P ¼ 0.04). There was no difference in corneal thickness between MPS I and MPS VI in the peripheral 7-10 mm zone (P ¼ 0.57). Measurements of the patient with MPS II resembled the mean values of the MPS I group. Conclusion AS-OCT is valuable in quantifying anterior segment pathology in MPS. It suggests more crowded anterior segments and greater corneal thickness in patients with MPS VI than MPS I. AS-OCT is useful in evaluating the risk and mechanism of glaucoma in MPS patients, and may improve our assessment of the efficacy of systemic treatment.

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Anterior Segment Optical Coherence Tomography Parameters in Subtypes of Primary Angle Closure

Cited by 86 publications

References 22 publications

Role of lens vault in subtypes of angle closure in Iranian subjects

Role of lens vault in subtypes of angle closure in Iranian subjects

Anterior Segment Parameters Associated to Acute Glaucoma with Slit Lamp Optical Coherence Tomography

Anterior segment OCT imaging in mucopolysaccharidoses type I, II, and VI

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