Anterior Segment Measurements Using Digital Photography: A Simple Technique

VanRoekel, R.C.; Bower, Kraig S.; Burka, Jenna M.; Howard, Robin S.

doi:10.1097/01.opx.0000221404.40296.ba

Cited by 11 publications

(10 citation statements)

References 9 publications

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“…While prospective in nature and making extensive use of computational analysis of digital corneal photographs, this study focused on corneal neovascularization rather than corneal ulceration and did not have a separate study to validate this methodology. VanRoekel and colleagues 20 presented an exploratory study assessing the area of 69 epithelial defects from digital slit-lamp pictures using Adobe Photoshop. The assessment performed by two physicians led to an excellent ICC of 0.99.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Fungal Keratitis using a Newly Developed Computer Program, Optscore, for Grading Digital Corneal Photographs

Toutain-Kidd

Porco

Kidd

et al. 2014

Ophthalmic Epidemiology

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Purpose To validate computer software developed to assess digital corneal photographs of fungal keratitis in clinical research. Methods A cornea specialist and five medical students (after training) graded on two occasions 100 corneal photographs of patients with fungal keratitis using Optscore software. Variables assessed were lesion area, location, degree of opacity, percentage of the ulcer lying within a central 4mm circle of the cornea. Intraclass correlation coefficients (ICCs) were used to assess intragrader reliability, agreement of the students with the corneal specialist, and the reliability of the group mean of the student raters. The area determined using Optscore was compared to the area estimated from slit lamp and to visual acuity. Results As a group, medical students achieved an ICC greater than 0.9 for five out of the seven assessed variables. Similar levels of consistency were found after analyzing the graders’ individual results compared to the specialist. The area estimated using slit lamp examination was highly correlated with the mean area determined by Optscore, as was the logarithm of the minimum angle of resolution visual acuity at enrollment. Conclusions Non-expert graders using Optscore to assess digital photographs of fungal keratitis are self-consistent, agree with an expert grader both as a group and individually, and measurements of ulcer area obtained from Optscore are highly correlated with measurements of the same patients obtained on clinical examination. These observations support the validity of Optscore for assessing corneal pathology associated with fungal keratitis and make it a promising clinical research tool.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Fungal Keratitis using a Newly Developed Computer Program, Optscore, for Grading Digital Corneal Photographs

Toutain-Kidd

Porco

Kidd

et al. 2014

Ophthalmic Epidemiology

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“…This was achieved by first outlining the limbus and the area of corneal neovascularization on the baseline images; the size of the neovascularized area was then measured in terms of pixels as described in a previous publication (Figure 1). 26 The location of subconjunctival vessels at the baseline visit was used to correct the magnification and fixation errors of the sequential images of each patient. Secondary outcome measures included the occurrence of adverse events, patient subjective observations, and the need for repeat surgery.…”

Section: Methodsmentioning

confidence: 99%

Single and multiple injections of subconjunctival ranibizumab for early, recurrent pterygium

Hürmeriç¹,

Vaddavalli²,

Pérez³

et al. 2013

OPTH

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PurposeTo assess the effect of single versus multiple subconjunctival ranibizumab injections in patients with an early pterygium recurrence.SettingSingle-center, academic practice.Study populationNine patients with early pterygium recurrence.Observational procedureSubconjunctival ranibizumab (0.5 mg/0.05 mL) was administered adjacent to pterygium recurrence. Group 1 (n = 5) received one injection; group 2 (n = 4) received three injections (time points 0, 2, and 4 weeks) with the ability to retreat as needed.Main outcome measuresEffect of ranibizumab on conjunctival hyperemia and corneal neovascular area over a 6-month follow-up period.ResultsIn the single injection group, a decrease in conjunctival hyperemia was noted in all patients on postinjection day 1. At follow up, hyperemia grade fluctuated, although all patients had less hyperemia than at baseline. In the recurrent injection group, the median number of injections was 8.5 (range 7 to 9) over the 6 months. In spite of the repeated injections, the pattern of conjunctival hyperemia was similar to that of the single injection group. In group 1, corneal neovascularization remained relatively unchanged over the 6-month period in four patients and decreased in one patient by 24%. In group 2, corneal neovascularization increased in one patient by 39%, remained stable in one patient, and decreased in two patients by 34% and 44%.ConclusionThis is the first study to evaluate the role of ranibizumab in the treatment of an early pterygium recurrence and the first to compare multiple versus single injections. Recurrent injections did not appear to be superior to a single injection with regards to conjunctival hyperemia.

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“…The size of the neovascularized area was then measured in terms of pixels as described in a previous publication. 25 The third measurement encompassed the corneal opacification area in front of the neovascularizated area of recurrent pterygium and its area determined in mm 2 was calculated using the method proposed by VanRoekel et al 25…”

Section: Outcome Measuresmentioning

confidence: 99%

Triple Subconjunctival Bevacizumab Injection for Early Corneal Recurrent Pterygium: One-Year Follow-Up

Nava-Castañeda

Ulloa-Orozco

Garnica-Hayashi

et al. 2015

Journal of Ocular Pharmacology and Therapeutics

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Anterior Segment Measurements Using Digital Photography: A Simple Technique

Abstract: This simple method, which allows accurate measurements from digital images using common off-the-shelf software, is a valuable tool for clinical documentation as well as for research purposes.

Cited by 11 publications

References 9 publications

Evaluation of Fungal Keratitis using a Newly Developed Computer Program, Optscore, for Grading Digital Corneal Photographs

Evaluation of Fungal Keratitis using a Newly Developed Computer Program, Optscore, for Grading Digital Corneal Photographs

Single and multiple injections of subconjunctival ranibizumab for early, recurrent pterygium

Triple Subconjunctival Bevacizumab Injection for Early Corneal Recurrent Pterygium: One-Year Follow-Up

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