Anterior segment angiography of the normal canine eye: A comparison between indocyanine green and sodium fluorescein

Pirie, Christopher G.; Alario, Anthony F.

doi:10.1016/j.tvjl.2013.12.011

Cited by 9 publications

(7 citation statements)

References 29 publications

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Section: Introductionmentioning

confidence: 99%

“…Due to the tendency of SF to leak through iridal vessels into the aqueous humor, 11 employing SF angiography in glaucomatous dogs may show increased leakage; if vascular compromise and subsequently increased vessel permeability exist. Unlike SF, the comparatively increased peak absorbance wavelength of ICG permits enhanced visualization of the iridal vasculature via reduced wavelength scatter and improved wavelength penetrability of pigmented structures, such as darkly pigmented irises 10 . Therefore, any existent delays in perfusion to the anterior segment vasculature should be detected by ICG.…”

Section: Introductionmentioning

confidence: 99%

“…The use and comparison of sodium fluorescein (SF) and indocyanine green (ICG) angiography to assess iridal vasculature in canines free of ophthalmic and systemic disease have been previously described. 10 Due to the tendency of SF to leak through iridal vessels into the aqueous humor, 11 employing SF angiography in glaucomatous dogs may show increased leakage; if vascular compromise and subsequently increased vessel permeability exist. Unlike SF, the comparatively increased peak absorbance wavelength of ICG permits enhanced visualization of the iridal vasculature via reduced wavelength scatter and improved wavelength penetrability of pigmented structures, such as darkly pigmented irises.…”

Section: Introductionmentioning

confidence: 99%

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Iris angiography in ADAMTS10 mutant dogs with open‐angle glaucoma (ADAMTS10‐OAG)

Pytak

Pirie

Harman

et al. 2023

Veterinary Ophthalmology

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ObjectiveTo evaluate anterior segment angiographic findings in hypertensive ADAMTS10‐open‐angle glaucoma (ADAMTS10‐OAG) eyes as compared to normotensive control eyes.Animals StudiedNine ADAMTS10‐OAG beagles and four wild‐type control dogs.ProceduresAnterior segment angiography was performed under general anesthesia following intravenous injection of indocyanine green (ICG; 1 mg/kg) and sodium fluorescein (SF; 20 mg/kg) using a Heidelberg Spectralis® confocal scanning laser ophthalmoscope. Time to onset of iridal angiographic phases and the presence/severity of dye leakage into the iris stromal and/or aqueous humor were recorded. Group findings were compared, and multiple linear regression analysis was performed to identify potential factor associations with disease status.ResultsTime to onset of all angiographic phases visualized using ICG was significantly prolonged while time to onset of SF leakage into the aqueous humor was significantly reduced in glaucomatous eyes compared to controls. Only glaucomatous eyes (n = 9) demonstrated evidence of SF stromal leakage. Mean intraocular pressure (IOP) and age were significantly higher, while mean cardiac pulse was significantly lower in glaucomatous eyes compared to controls. Blood pressure and ocular perfusion pressure were not significantly different between groups. Multiple linear regression analysis, controlling for age, IOP, and pulse demonstrated glaucoma, was not predictive of the time to onset of any angiographic phase, stromal, or aqueous humor leakage. However, pulse was a significant factor contributing to the severity of aqueous humor leakage.ConclusionsA compromised vascular supply to the anterior segment exists in dogs with ADAMTS10‐OAG. These observations warrant further exploration of what role altered perfusion and/or disruption to the blood–aqueous barrier may play.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Iris angiography in ADAMTS10 mutant dogs with open‐angle glaucoma (ADAMTS10‐OAG)

Pytak

Pirie

Harman

et al. 2023

Veterinary Ophthalmology

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“…Fluorescein and indocyanine green angiography have been described in domestic animals (dogs, cats, and horses) for assessment of both the posterior segment (retina) and anterior segment (iris) vasculature. [57][58][59][60][61][62][63][64][65][66][67][68] Fluorescein angiography (FA) and indocyanine green angiography (ICGA) are more commonly used in research studies using large and small animal experimental models such as non-human primates (NHP), rabbits, pigs, dogs, and rodent models of retinal neovascularization, vascular leakage, inherited retinal degenerations, retinal detachments, and other diseases. [69][70][71][72][73] Due to differences in physical characteristics, FA is preferred for the study of the retinal vessels whereas ICGA is used to study choroidal vasculature.…”

Section: Introductionmentioning

confidence: 99%

“…It is used as a diagnostic tool for the investigation of retino‐choroidal diseases in humans, and to a lesser extent in animals. Fluorescein and indocyanine green angiography have been described in domestic animals (dogs, cats, and horses) for assessment of both the posterior segment (retina) and anterior segment (iris) vasculature 57–68 . Fluorescein angiography (FA) and indocyanine green angiography (ICGA) are more commonly used in research studies using large and small animal experimental models such as non‐human primates (NHP), rabbits, pigs, dogs, and rodent models of retinal neovascularization, vascular leakage, inherited retinal degenerations, retinal detachments, and other diseases 69–73 …”

Section: Introductionmentioning

confidence: 99%

Non‐invasive optical coherence tomography angiography: A comparison with fluorescein and indocyanine green angiography in normal adult dogs and cats

Occelli

Pirie

Petersen‐Jones

2022

Veterinary Ophthalmology

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While the retinal vasculature can be assessed by simple funduscopy, a more detailed assessment can be performed by conventional angiography using dyes such as fluorescein or indocyanine green. The development of optical coherence tomography angiography (OCT-A) allows a non-invasive detailed examination of posterior segment vasculature. The purpose of this prospective study was to compare imaging of posterior segment vasculature in normal dogs and cats using OCT-A, fluorescein angiography (FA), and indocyanine green angiography (ICGA). Methods: Eight adult funduscopically normal dogs and 13 funduscopically normal cats were included in the study. Retinal vasculature was assessed by OCT-A followed by ICGA then FA. Regular fundus imaging was also performed. Results: High-resolution images of the different vascular layers within the retina and choroid could be acquired using OCT-A in both dogs and cats. The technique provided more detail than obtained with FA/ICGA. However, artifacts/errors can occur during OCT-A image acquisition/analysis/interpretation and must be considered. Furthermore, OCT-A only allows for a limited field of view compared to FA/ICGA. Conclusions: Optical coherence tomography angiography is a new non-invasive posterior segment imaging technique that is complementary to traditional dyebased angiographic techniques. Detailed imaging of the dog and cat posterior segment can be achieved under general anesthesia. OCT-A provides additional detail of the vasculature and can clearly demonstrate the anatomical depth of the imaged vessels. There are, however, some limitations to this new technique that may be overcome by future technological advances.

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Advanced Imaging of the Equine Eye

Gilger

2017

Veterinary Clinics of North America: Equine Practice

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Anterior segment angiography of the normal canine eye: A comparison between indocyanine green and sodium fluorescein

Cited by 9 publications

References 29 publications

Iris angiography in ADAMTS10 mutant dogs with open‐angle glaucoma (ADAMTS10‐OAG)

Iris angiography in ADAMTS10 mutant dogs with open‐angle glaucoma (ADAMTS10‐OAG)

Non‐invasive optical coherence tomography angiography: A comparison with fluorescein and indocyanine green angiography in normal adult dogs and cats

Advanced Imaging of the Equine Eye

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