Anterior Pituitary Failure

Carmichael, John D.

doi:10.1016/b978-0-12-380926-1.10010-0

Cited by 8 publications

(6 citation statements)

References 257 publications

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“…Table shows data from fifteen studies of cortisol levels in acute TBI. The American College of Critical Care Medicine, after a literature review, proposed a cortisol cut‐off 276 nmol/L as level defining adrenal deficiency in critical illness . Cohan et al advised using a 414 nmol/L (15 μg/dL) cut‐off to confirm AI in acute TBI after a study in which 80 victims were compared with a control group .…”

Section: Discussionmentioning

confidence: 99%

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Cortisol evaluation during the acute phase of traumatic brain injury—A prospective study

Bensalah¹,

Donaldson

Aribi³

et al. 2018

Clinical Endocrinology

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Section: Discussionmentioning

confidence: 99%

“…Adrenal insufficiency was defined using three cortisol cut‐offs: 83 nmol/L; a value accepted as indicating severe adrenal deficiency 276 nmol/L; a value indicating adrenal deficiency in critical illness according to the consensus statements from an international task force by the American College of Critical Care Medicine …”

Section: Methodsmentioning

confidence: 99%

Cortisol evaluation during the acute phase of traumatic brain injury—A prospective study

Bensalah¹,

Donaldson

Aribi³

et al. 2018

Clinical Endocrinology

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“…Occlusion of capillaries by lymphoma cells in multiple organs results in extremely variable clinical manifestations. In addition, patients with IVLBCL present with variable B symptoms, such as fever, weight loss, night sweats, malaise, fatigue, cutaneous lesions, neurological symptoms, gastrointestinal symptoms, edema, and dyspnea (Carmichael 2011). Laboratory findings of IVLBCL often show anemia, leukocytopenia, thrombocytopenia, hypoalbuminemia, and elevated C-reactive protein (CRP), LDH, and sIL-2R levels (Ferreri et al 2004;Ponzoni et al 2007;Shimada et al 2009).…”

Section: Discussionmentioning

confidence: 99%

“…A precise evaluation of pituitary function often requires provocative testing. Patients with hypopituitarism are usually treated with hormone replacement therapy (Carmichael 2011). Lymphoma is one of the potential causes for pituitary dysfunction, whereas there have been less than 20 case reports of hypopituitarism induced by IVLBCL.…”

Section: Introductionmentioning

confidence: 99%

Reversible Hypopituitarism Associated with Intravascular Large B-Cell Lymphoma: Case Report of Successful Immunochemotherapy

Sawada

Ishii

Koga

et al. 2016

Tohoku J. Exp. Med.

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Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of diffuse large B-cell lymphoma. There have been only a limited number of reports regarding pituitary dysfunction associated with IVLBCL. We present a 71-year-old woman with hypopituitarism without any hypothalamic/pituitary abnormalities as assessed by magnetic resonance imaging. She presented with edema, abducens palsy, and elevated levels of lactate dehydrogenase and soluble interleukin-2 receptor. Provocative testing showed that the peaks of luteinizing hormone, follicle-stimulating hormone, thyroid-stimulating hormone and adrenocorticotropic hormone were evoked to normal levels by simultaneous administration of luteinizing hormone-releasing hormone, thyrotropin-releasing hormone and corticotropin-releasing hormone, but the responses of these four pituitary hormones showed a delayed pattern. She was diagnosed with IVLBCL with cerebrospinal invasion by pathological findings of the bone marrow, skin, and cerebrospinal fluid. She achieved hematological remission after immunochemotherapy. Pituitary function was also restored without hormonal replacement, and the improvement of the pituitary function was confirmed by dynamic testing. We reviewed the literature with respect to hypopituitarism associated with IVLBCL. There were less than 20 case reports and most of the patients died. Endocrinological course was described in only two cases, and both of them required hormonal supplementation. To our knowledge, this is the first case of hypopituitarism induced by IVLBCL that was successfully managed by immunochemotherapy alone. This case suggests that early diagnosis and treatment of IVLBCL might improve anterior pituitary function and enable patients to avoid hormone replacement therapy.

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“…5,9,10 Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) deficiencies were presumed in the absence of pubertal signs in girls and boys older than 13 and 14 years old respectively associated with prepubertal gonadotropin values. 5,11 Antidiuretic hormone (ADH) deficiency was characterized by polyuria and polydipsia associated with plasma sodium >145mmol/L, serum osmolality >300mOsm/kg and urine osmolality <300mOsm/ kg. 5 We compared the growth velocity and height SDS just before and one year after the beginning of replacement therapy with rhGH.…”

Section: Introductionmentioning

confidence: 99%

Neuroimaging findings and severity of hypopituitarism in a cohort of 78 children

Castro¹,

Beserra²

2021

IJRRT

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Objectives: To evaluate neuroimaging abnormalities in children with hypopituitarism and correlate with the number of pituitary hormone deficiencies, age at diagnosis, severity of growth hormone deficiency and response in the first year of treatment with recombinant human growth hormone. Material and methods: It was a cross-sectional descriptive study. Children with hypopituitarism followed at a pediatric university hospital over a 10-year period were included. All neuroimaging were reviewed by the researcher and classified as: normal, with hypoplastic adenohypophysis, absent pituitary stalk, ectopic neurohypophysis or empty sella. The Fisher-exact and the Mann-Whitney tests were applied for categorical and numerical data, respectively. The distribution of numerical variables was assessed by Shapiro-Wilks test. The significance level adopted was 5%. Results: Seventy-eight patients aged between 0.5 and 17.82 years were included in the study. We found male predominance. Only 29.5% of patients had normal magnetic imaging resonance, with hypoplastic adenohypophysis being the most frequent abnormality. Half of the patients had neonatal complications history. The same proportion of isolated growth hormone deficiency and multiple pituitary hormones deficiencies were found. Severe growth hormone deficiency was found in 82% of patients with neuroimaging abnormalities. Appropriate response to therapy was observed in 76.6% of patients, being more prevalent in those with multiple pituitary hormones deficiencies. Conclusions: The presence of neuroimaging abnormalities was related to multiple pituitary hormones deficiencies, severe growth hormone deficiency and neonatal abnormalities, without however having relation to early-onset of disease.

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Anterior Pituitary Failure

Cited by 8 publications

References 257 publications

Cortisol evaluation during the acute phase of traumatic brain injury—A prospective study

Cortisol evaluation during the acute phase of traumatic brain injury—A prospective study

Reversible Hypopituitarism Associated with Intravascular Large B-Cell Lymphoma: Case Report of Successful Immunochemotherapy

Neuroimaging findings and severity of hypopituitarism in a cohort of 78 children

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