“…Free grafts and currently used intranasal flaps [e.g., HBF [11], posterior and anterior pedicled ITFs [1,8,10], middle turbinate flap [25], anterior pedicled lateral nasal wall flap [12], bipedicled anterior septal flap [3]] are inadequate for large skull base defects resulting from EEAs (especially combined approaches) [8], for which reconstruction with vascularized tissue has been inferior turbinate arteries, d1 lower nasal septal artery, d2 medial nasal septal artery, d3 upper nasal septal artery, e1, e2 arteries branching from the PLNA that anastomose the inferior turbinate artery and nasal septal artery networks, f branches of the anterior ethmoid artery, g branches from the branches of the facial artery shown to be fundamental in reducing the incidence of CSF leakage. The use of regional flaps is limited by the difficulty of their creation and application [7,28].…”