Anterior mediastinal seminoma with myasthenia gravis: A rare case report and literature review

Abstract

Background:Myasthenia gravis may be associated with thymic follicular hyperplasia or thymomas. We present a case of an anterior mediastinal tumor with myasthenia gravis, which turned out to be seminoma. We also review the literature on seminoma with myasthenia gravis in this article.Case presentation:A 34-year-old man presented to our hospital with a complaint of diplopia. Single fiber electromyography revealed ocular myasthenia gravis; chest computed tomography showed a 1.5 cm anterior mediastinum nodule suspected as thymoma. The patient underwent video-assisted thoracoscopic thymectomy. Histopathological findings revealed seminoma with thymic follicular hyperplasia.Conclusion:Anterior mediastinal seminoma with thymic follicular hyperplasia is rare and extremely rare with associated myasthenia gravis. Though rare, young male patient with anterior mediastinal tumor and myasthenia gravis, thymic seminoma is one possible cause. Testicular examination can be taken into consideration before operation.