Anterior Insular-nucleus Accumbens Pathway Controls Refeeding-induced Analgesia under Chronic Inflammatory Pain Condition

Lee, Grace J.; Kim, Yea Jin; Shim, Sang Wook; Lee, Kihwan; Oh, Seunghee

doi:10.1016/j.neuroscience.2022.05.025

Cited by 3 publications

(2 citation statements)

References 70 publications

(51 reference statements)

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“…Thus, different aINS projections may come from relatively distinct subgroup of aINS cells, with potential for different firing patterns. As noted above, aINS-NAcb has been related to several CLAD behaviors, and a recent preprint implicates it in expression of chronic pain [105]. Additionally, we find that that aINS-Locus Coeruleus Area contributes more to CLAD than AOD [34], similar to certain aspects of NMDA (see [23]) and orexin (see [106]) receptor signaling.…”

Section: Discussionsupporting

confidence: 63%

Anterior insular cortex firing links initial and sustained encoding during aversion-resistant alcohol consumption

Starski

Morningstar

Katner

et al. 2022

Preprint

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Compulsive-like alcohol drinking (CLAD), where intake persists despite adverse consequences, is often a core facet of alcohol use disorder. Recent work sheds light on underlying mechanisms, but much remains unknown about CLAD etiology. Previously, we showed that projections from anterior insula (aINS), a central mediator of emotion, motivation, and interoception, promote CLAD in rodents, and heavy human drinkers exhibit similar insula-circuit recruitment under compulsion-like conditions. However, global aINS inhibition also reduces alcohol-only drinking (AOD), and one major obstacle is the lack of information on aINS firing patterns that could promote different aspects of intake. Here, we recorded single-unit activity in right aINS from 15 rats during AOD or CLAD (10mg/L or 60mg/L quinine in alcohol). Neurons with a sustained-increase or sustained-decrease phenotype (SIP, SDP) showed no firing differences across drinking conditions. In contrast, aINS neurons with a phenotype of strong firing increase at initiation of responding (IRP) showed significantly greater activity across the rest of licking during CLAD versus AOD, concurring with our previous behavioral findings suggesting quick evaluation and response strategy adjustment under CLAD. There were also no condition-related differences in firing-phenotype abundance. Further, total responding only correlated with abundance of SDP cells, but SDP firing returned to baseline during pauses in licking, while IRP and SIP sustained responding through pauses in licking. Thus, only aINS cells with a particular strong firing at licking onset showd greater sustained responding under compulsion-like conditions, while other cells likely promoted drinking more generally, providing critical new information about how aINS activity could promote alcohol consumption under different drinking conditions.

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Section: Discussionsupporting

confidence: 63%

Anterior insular cortex firing links initial and sustained encoding during aversion-resistant alcohol consumption

Starski

Morningstar

Katner

et al. 2022

Preprint

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“…A change in frequency of feeding is commonly used as a pain indicator in both acute and chronic pain ( 107 ), and can of course be reflected in body weight changes. A recent study has also investigated refeeding-induced analgesia in inflammatory pain, determining that the mechanism of this response via neural activities in the nucleus accumbens and anterior insula cortex may be a target target for chronic pain management ( 107 ). Measuring bodyweight is often the mainstay method used by researchers to assess pain in biomedical research as part of daily animal health checks.…”

Section: Organic Responses Derived From Pain In Relation To Pain Asse...mentioning

confidence: 99%

The neurobiology of pain and facial movements in rodents: Clinical applications and current research

et al. 2022

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One of the most controversial aspects of the use of animals in science is the production of pain. Pain is a central ethical concern. The activation of neural pathways involved in the pain response has physiological, endocrine, and behavioral consequences, that can affect both the health and welfare of the animals, as well as the validity of research. The strategy to prevent these consequences requires understanding of the nociception process, pain itself, and how assessment can be performed using validated, non-invasive methods. The study of facial expressions related to pain has undergone considerable study with the finding that certain movements of the facial muscles (called facial action units) are associated with the presence and intensity of pain. This review, focused on rodents, discusses the neurobiology of facial expressions, clinical applications, and current research designed to better understand pain and the nociceptive pathway as a strategy for implementing refinement in biomedical research.

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Abnormal functional connectivity of the reward circuit associated with early satiety in patients with postprandial distress syndrome

Zhang,

Mao,

Gao

et al. 2024

Appetite

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Anterior Insular-nucleus Accumbens Pathway Controls Refeeding-induced Analgesia under Chronic Inflammatory Pain Condition

Cited by 3 publications

References 70 publications

Anterior insular cortex firing links initial and sustained encoding during aversion-resistant alcohol consumption

Anterior insular cortex firing links initial and sustained encoding during aversion-resistant alcohol consumption

The neurobiology of pain and facial movements in rodents: Clinical applications and current research

Abnormal functional connectivity of the reward circuit associated with early satiety in patients with postprandial distress syndrome

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