“…Assessment of the AF surface area (AFSA) is routine in infant (Duc and Largo, 1986) and fetal examination as three-dimensional (3D) ultrasound techniques have made in utero assessment of craniofacial morphology, including the AF, possible Faro et al, 2005Faro et al, , 2006. Such assessment is critical as irregular development in this structure may indicate abnormal craniofacial growth (Davies et al, 1975;Philip, 1978;Paladini et al, 2007Paladini et al, , 2008. For example, reduction of AFSA is common among premature infants with intrauterine growth retardation (Davies et al, 1975;Philip, 1978) and fetuses with craniosynostosis (Kreiborg et al, 1993;Cohen and MacLean, 2000), whereas large fontanelles (including the AF) are common among fetuses with Down syndrome (Paladini et al, 2007(Paladini et al, , 2008 and congenital hypothyroidism .…”