Anterior dislocation of the restrained shoulder: a seat-belt injury.

Salam, A A; Eyres, K. S.; Magides, A. D.; Cleary, J

doi:10.1136/emj.8.1.56

Cited by 4 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Intra-peritoneal rupture of distended urinary bladder may occur when the horizontal strap of the seatbelt increases the intra-vesical pressure [ 52 ]. Blunt traumatic aortic rupture [ 53 ], sternal fractures [ 41 ], clavicle fractures [ 32 ] and shoulder dislocations [ 54 ] were also reported as a complication of seatbelts. Cervical spinal injuries were noticed to be higher in restrained children than non-restrained children [ 19 , 32 , 55 ].…”

Section: Seatbelt-related Injuriesmentioning

confidence: 99%

Seatbelts and road traffic collision injuries

2011

View full text Add to dashboard Cite

Modification of seatbelts and their legislation played an important role in reducing morbidity and mortality of occupants in road traffic collisions. We aimed to review seatbelt development, its mechanism of action and its effects. Seatbelts reduce injury by preventing the occupant from hitting the interior parts of the vehicle or being ejected from the car. We have made a linear regression correlation between the overall seatbelt compliance and road traffic death rates in 46 high income countries to study the relationship between seatbelt use and mortality. There was a very highly significant negative correlation between the seatbelt compliance and road traffic death rates (R = - 0.77, F = 65.5, p < 0.00001). Seatbelt-related injuries include spinal, abdominal or pelvic injuries. The presence of a seatbelt sign must raise the suspicion of an intra-abdominal injury. These injuries can be reduced if seatbelts were applied correctly. Although seatbelts were recognized as an important safety measure, it still remains underused in many countries. Enforcement of seatbelt usage by law is mandatory so as to reduce the toll of death of road traffic collisions.

show abstract

Section: Seatbelt-related Injuriesmentioning

confidence: 99%

Seatbelts and road traffic collision injuries

2011

View full text Add to dashboard Cite

show abstract

“…Quantitative shotgun proteomics is now widely used as a potent technology for discovery-based analysis of complex biological systems. The approach of immunoaffinity enrichment followed by mass spectrometry allows identification of low abundance tyrosine phosphorylated proteins (22). A global study has identified several oncogenic kinases such as EGFR, c-MET, PDGFR␣, DDR1, and novel ALK and ROS fusions in non small cell lung cancer (NSCLC) cell lines (23) and tumor specimens (24).…”

mentioning

confidence: 99%

Quantitative Tyrosine Phosphoproteomics of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor-treated Lung Adenocarcinoma Cells Reveals Potential Novel Biomarkers of Therapeutic Response

Zhang

Maity

Kashyap

et al. 2017

Molecular & Cellular Proteomics

View full text Add to dashboard Cite

Mutations in the Epidermal growth factor receptor (EGFR) kinase domain, such as the L858R missense mutation and deletions spanning the conserved sequence LREA, are sensitive to tyrosine kinase inhibitors (TKIs). The gatekeeper site residue mutation, T790M accounts for around 60% of acquired resistance to EGFR TKIs. The first generation EGFR TKIs, erlotinib and gefitinib, and the second generation inhibitor, afatinib are FDA approved for initial treatment of EGFR mutated lung adenocarcinoma. The predominant biomarker of EGFR TKI responsiveness is the presence of TKI-sensitizing mutations. However, 30-40% of patients with mutations exhibit primary resistance to these TKIs, underscoring the unmet need of identifying additional biomarkers of treatment response. Here, we sought to characterize the dynamics of tyrosine phosphorylation upon EGFR TKI treatment of mutant EGFR-driven human lung adenocarcinoma cell lines with varying sensitivity to EGFR TKIs, erlotinib and afatinib. We employed stable isotope labeling with amino acids in cell culture (SILAC)-based quantitative mass spectrometry to identify and quantify tyrosine phosphorylated peptides. The proportion of tyrosine phosphorylated sites that had reduced phosphorylation upon erlotinib or afatinib treatment correlated with the degree of TKI-sensitivity. Afatinib, an irreversible EGFR TKI, more effectively inhibited tyrosine phosphorylation of a majority of the substrates. The phosphosites with phosphorylation SILAC ratios that correlated with the TKI-sensitivity of the cell lines include sites on kinases, such as EGFR-Y1197 and MAPK7-Y221, and adaptor proteins, such as SHC1-Y349/350, ERRFI1-Y394, GAB1-Y689, STAT5A-Y694, DLG3-Y705, and DAPP1-Y139, suggesting these are potential biomarkers of TKI sensitivity. DAPP1, is a novel target of mutant EGFR signaling and Y-139 is the major site of DAPP1 tyrosine phosphorylation. We also uncovered several off-target effects of these TKIs, such as MST1R-Y1238/Y1239 and MET-Y1252/1253. This study provides unique insight into the TKI-mediated modulation of mutant EGFR signaling, which can be applied to the development of biomarkers of EGFR TKI response.

show abstract

“… 2 We found one report in the literature addressing the relationship between anterior dislocation of the restrained shoulder and seatbelts. 3 We recently treated a restrained driver and a restrained front-seat passenger who had contra-lateral (mirror) anterior dislocation of the shoulders. Mirror injuries caused by 3-point seatbelts may involve both the driver and the front-seat passenger.…”

mentioning

confidence: 99%