Anterior Cruciate Ligament Reconstruction With LARS Artificial Ligament: A Multicenter Study With 3- to 5-Year Follow-up

Gao, Kai; Chen, Shiyi; Wang, Lide; Zhang, Weiguo; Kang, Yifan; Dong, Qirong; Zhou, Haibin; Li, Linan

doi:10.1016/j.arthro.2010.02.001

Cited by 134 publications

(141 citation statements)

References 26 publications

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“…Dericks [40] described his experience of 220 patients reported 3 infections (1.4%) and 9 ligament ruptures (4.1%) with 83% of patients returning to full sports by 6 mo (and 61% by as early as 4 mo). The largest published study of LARS ACL reconstructions is by Gao et al [41] who retrospectively report on 159 reconstructions. They describe 94% of patients achieving IKDC grade A or B at a mean of 50 mo follow-up.…”

Section: Graft Choicementioning

confidence: 99%

Anterior cruciate ligament reconstruction best practice: A review of graft choice

Shaerf

Pastides

Sarraf

et al. 2014

WJO

119

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There is much literature about differing grafts used in anterior cruciate ligament (ACL) reconstruction. Much of this is of poor quality and of a low evidence base. We review and summarise the literature looking at the four main classes of grafts used in ACL reconstruction; bone-patella tendon-bone, hamstrings, allograft and synthetic grafts. Each graft has the evidence for its use reviewed and then compared, where possible, to the others. We conclude that although there is no clear "best" graft, there are clear differences between the differing graft choices. Surgeon's need to be aware of the evidence behind these differences, in order to have appropriate discussions with their patients, so as to come to an informed choice of graft type to best suit each individual patient and their requirements.

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Section: Graft Choicementioning

confidence: 99%

Anterior cruciate ligament reconstruction best practice: A review of graft choice

Shaerf

Pastides

Sarraf

et al. 2014

WJO

119

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“…By analysing ruptured ACL artificial ligaments, Guidoin et al [5] observed a chronic inflammatory reaction with macrophages and giant cells in the polyester ligaments. In a three to five year follow-up multicentre study, Gao et al [6] reported that seven of 156 cases of ACL reconstruction using the LARS ligament were noted to exhibit graft failure at the bone tunnel, and they found that an interposed layer of fibrous scar tissue appears at the graft-bone interface at the second arthroscopic revision surgery. It was presumed that the inflammation at the graftbone interface might induce the scar tissue formation and hamper the graft osseointegration within the bone tunnel.…”

Section: Introductionmentioning

confidence: 99%

Cationised gelatin and hyaluronic acid coating enhances polyethylene terephthalate artificial ligament graft osseointegration in porcine bone tunnels

Cho

Chen

et al. 2012

International Orthopaedics (SICOT)

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Purpose The aim of this study was to investigate whether cationised gelatin and hyaluronic acid (CH) coating could induce polyethylene terephthalate (PET) artificial ligament graft osseointegration in the bone tunnel. Methods Surface modification of PET artificial ligament graft was performed by layer-by-layer (LBL) self-assembly CH coating. Six pigs underwent anterior cruciate ligament (ACL) reconstruction on the right knees, with three pigs receiving the CH-coated PET grafts and the other three pigs non-CH-coated PET grafts as controls. They were sacrificed at three months after surgery and the graft-bone complexes were acquired for computed tomography (CT) scan and histological examination. Results CT scans showed a significant difference at the distal femoral site (p00.031) or at the distal tibial site (p00.0078), but no significant difference in the bone tunnel areas' enlargement at other sites (p>0.05) between the CH group and the control group. Histologically, application of CH coating induced new bone formation between graft and bone at three months compared with the controls at the distal site. The interface width of the CH group was significantly lower than that of the control group at the distal femoral site (p00.0327) and at the distal tibial site (p00.0047). ConclusionsThe study has shown that CH coating on the PET artificial ligament surface has a positive biological effect in the induction of artificial ligament osseointegration within the bone tunnel at the distal site of the bone tunnel.

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“…Because it is a permanent artificial graft in the bone tunnel, the graft healing of the LARS artificial ligament is the major problem that must be considered, as the healing is directly related to the longterm stability of the graft in the bone tunnel. As reported previously [4,5], the LARS ligament appears to have poor osseointegration with the surrounding bone because of its hydrophobicity and chemical inertia. Often, a band of fibrous scar tissue forms between the artificial ligament graft and the bone tunnel, and subsequently results in ligament loosening and graft failure.…”

Section: Introductionmentioning

confidence: 81%

Enhancement of the osseointegration of a polyethylene terephthalate artificial ligament graft in a bone tunnel using 58S bioglass

Chen

et al. 2011

International Orthopaedics (SICOT)

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Purpose The aim of the study was to investigate whether a bioactive glass (BG) coating on the polyethylene terephthalate (PET) artificial ligament could enhance graft osseointegration by promoting bone regeneration at the interface between PET graft and bone tunnel. Methods Thirty New Zealand white rabbits underwent artificial ligament graft transplantation in proximal tibial tunnels bilaterally. One limb was implanted with a 58S BGcoated PET graft, and the contralateral limb was implanted with a non-BG-coated PET graft as a control. The rabbits were randomly sacrificed at three, six and 12 weeks after surgery for biomechanical and histological examinations. Results The maximum load to failures of the BG-coated experimental group were significantly higher than those of the control group at 12 weeks (p=0.0051). Histologically, at 12 weeks, the BG-coated PET graft induced great new bone formation between graft and host bone, and the average graft-bone interface width of the BG group became significantly lower than that of the control group. Furthermore, the BG coating on the ligament graft surface also stimulated greater expression of bone morphogenetic protein 2 (BMP-2) and vascular endothelial growth factor (VEGF) around the graft in vivo compared to the control group at three weeks (p<0.05).Conclusions This study has shown that a BG coating on the PET artificial ligament surface has a positive effect in the induction of artificial ligament osseointegration within the bone tunnel.

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Anterior Cruciate Ligament Reconstruction With LARS Artificial Ligament: A Multicenter Study With 3- to 5-Year Follow-up

Cited by 134 publications

References 26 publications

Anterior cruciate ligament reconstruction best practice: A review of graft choice

Anterior cruciate ligament reconstruction best practice: A review of graft choice

Cationised gelatin and hyaluronic acid coating enhances polyethylene terephthalate artificial ligament graft osseointegration in porcine bone tunnels

Enhancement of the osseointegration of a polyethylene terephthalate artificial ligament graft in a bone tunnel using 58S bioglass

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