Anterior cruciate ligament prostheses using biotextiles☆

Laflamme, M.; Lamontagne, J.; Guidoin, R.

doi:10.1016/b978-1-78242-017-0.00007-6

Cited by 2 publications

(3 citation statements)

References 142 publications

(149 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rather than non-degradable materials to compose permanent scaffolds, biodegradable materials degenerate in surgically created bone tunnels after implantation and leave space for natural tissue to creep back, thus have been employed in artificial ligament fabrication in recent years. Biodegradable materials used in artificial ligament composition, including natural polymers like collagen, silk, CHI, HA, synthetic polymers such as PLA, PGA, PLGA, PCL, and biodegradable based polymeric composites, have been used to produce scaffolds for biodegradable tendon and ligament tissue engineering as gels, membranes, or three-dimensional fibrous scaffolds [ [55] , [56] , [57] ]. Although these biodegradable scaffolds have been confirmed with good histocompatibility and osteoinductivity by previous research claiming that these scaffolds could promote healing between the graft and bone tunnels by leaving space for autologous tissue creep replacement, poor biomechanical properties have restricted them from further clinical application.…”

Section: Strategies For Promotion Of Artificial Ligament Bioactivitymentioning

confidence: 99%

“…Popular artificial ligaments are woven, knitted, or braided in various ways and possess different textiles, which largely accounts for prostheses' overall behavior. For artificial ligament prostheses, an interconnected pore network, in an order to allow the adhesion and migration of cells and growth of autologous tissue that creeps back, has been considered the essential morphological requirement aside from mimicking mechanical responses of native ACL [ 57 , 94 ].…”

Section: Manufacturing Technologies For Artificial Ligament Bioactivi...mentioning

confidence: 99%

See 1 more Smart Citation

Current strategies for enhancement of the bioactivity of artificial ligaments: A mini-review

Wang

et al. 2022

Journal of Orthopaedic Translation

View full text Add to dashboard Cite

Section: Strategies For Promotion Of Artificial Ligament Bioactivitymentioning

confidence: 99%

Section: Manufacturing Technologies For Artificial Ligament Bioactivi...mentioning

confidence: 99%

Current strategies for enhancement of the bioactivity of artificial ligaments: A mini-review

Wang

et al. 2022

Journal of Orthopaedic Translation

View full text Add to dashboard Cite

“…Guidoin et al [ 188 ] reported that a thick collagenous tissue partly penetrated the outer layers of the braided structure of a UHMWPE prosthesis. This collagen penetration caused the expansion and separation of the multifilament yarns into individual fibers.…”

Section: Relationship Between Human Ligament and Uhmwpementioning

confidence: 99%

Functional Ultra-High Molecular Weight Polyethylene Composites for Ligament Reconstructions and Their Targeted Applications in the Restoration of the Anterior Cruciate Ligament

et al. 2022

View full text Add to dashboard Cite

The selection of biomaterials as biomedical implants is a significant challenge. Ultra-high molecular weight polyethylene (UHMWPE) and composites of such kind have been extensively used in medical implants, notably in the bearings of the hip, knee, and other joint prostheses, owing to its biocompatibility and high wear resistance. For the Anterior Cruciate Ligament (ACL) graft, synthetic UHMWPE is an ideal candidate due to its biocompatibility and extremely high tensile strength. However, significant problems are observed in UHMWPE based implants, such as wear debris and oxidative degradation. To resolve the issue of wear and to enhance the life of UHMWPE as an implant, in recent years, this field has witnessed numerous innovative methodologies such as biofunctionalization or high temperature melting of UHMWPE to enhance its toughness and strength. The surface functionalization/modification/treatment of UHMWPE is very challenging as it requires optimizing many variables, such as surface tension and wettability, active functional groups on the surface, irradiation, and protein immobilization to successfully improve the mechanical properties of UHMWPE and reduce or eliminate the wear or osteolysis of the UHMWPE implant. Despite these difficulties, several surface roughening, functionalization, and irradiation processing technologies have been developed and applied in the recent past. The basic research and direct industrial applications of such material improvement technology are very significant, as evidenced by the significant number of published papers and patents. However, the available literature on research methodology and techniques related to material property enhancement and protection from wear of UHMWPE is disseminated, and there is a lack of a comprehensive source for the research community to access information on the subject matter. Here we provide an overview of recent developments and core challenges in the surface modification/functionalization/irradiation of UHMWPE and apply these findings to the case study of UHMWPE for ACL repair.

show abstract

Anterior cruciate ligament prostheses using biotextiles☆

Cited by 2 publications

References 142 publications

Current strategies for enhancement of the bioactivity of artificial ligaments: A mini-review

Current strategies for enhancement of the bioactivity of artificial ligaments: A mini-review

Functional Ultra-High Molecular Weight Polyethylene Composites for Ligament Reconstructions and Their Targeted Applications in the Restoration of the Anterior Cruciate Ligament

Contact Info

Product

Resources

About