Anterior cingulate volume predicts response to cognitive behavioral therapy in major depressive disorder

Fujino, Junya; Yamasaki, Nobuyuki; Miyata, Jun; Sasaki, Hirokazu; Matsukawa, Noriko; Takemura, Ariyoshi; Tei, Shisei; Sugihara, Genichi; Aso, Toshihiko; Fukuyama, Hidenao; Takahashi, Hidehiko; Inoue, Kazuomi; Murai, Toshiya

doi:10.1016/j.jad.2014.12.009

Cited by 43 publications

(16 citation statements)

References 17 publications

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“…The executive control of attention has been extensively related to the activity of several frontal and parietal areas (FPN37), and in particular to the activation of the ACC, which depends on the mesocortical DA system383940. Hypofunction and abnormal structure in ACC have been shown to be associated with major depression4142. Therefore, the impairment of executive control function in MDD may be caused by dysfunction of this region within the FPN.…”

Section: Discussionmentioning

confidence: 99%

Venlafaxine treatment reduces the deficit of executive control of attention in patients with major depressive disorder

Tian

Spagna

Mackie

et al. 2016

Sci Rep

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Attention plays an essential role in supporting other cognitive functions and behavior, and disturbance of attention is one of the most common symptoms in major depressive disorder (MDD). Although treatment with venlafaxine for MDD symptoms has been shown to reduce deficits in cognition and emotion regulation, it remains unclear whether venlafaxine improves specific attentional functions. We used the Attention Network Test to measure the attentional functions of alerting, orienting, and executive control before and after treatment with venlafaxine in patients with MDD compared to untreated healthy controls. Before treatment, the MDD group showed a selective impairment in alerting and executive control of attention, while there were no significant group differences in the orienting function. The interaction between group and session was significant for executive control, and after treatment with venlafaxine, the performance of the MDD group on executive control of attention was not significantly different from that of controls. Reported symptoms of MDD were also significantly reduced after treatment with venlafaxine. These results demonstrate that treatment with venlafaxine selectively normalizes the executive control function of attention in addition to improving clinical symptoms in MDD.

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Section: Discussionmentioning

confidence: 99%

Venlafaxine treatment reduces the deficit of executive control of attention in patients with major depressive disorder

Tian

Spagna

Mackie

et al. 2016

Sci Rep

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“…Absent from these studies, however, has been analysis of the anterior cingulate cortex (AnCg), a brain region centrally involved in the regulation of mood, affect and cognition (Drevets et al, 2008, Ebert and Ebmeier, 1996, Mayberg et al, 1999, Posner and DiGirolamo, 1998). Alterations in AnCg function have been increasingly linked to mood disorders with AnCg activity previously demonstrated to differentiate patients with unipolar versus bipolar depression (Diler et al, 2014) and also to predict successful pharmaceutical and cognitive treatment response (Fujino et al, 2015, Mulert et al, 2007, Pizzagalli et al, 2001, Salvadore et al, 2009). Further work has also established alterations in various systems within AnCg in MDD and BP disorders, including dysregulation in the fibroblast growth factor (FGF) system and clock genes (Bunney et al, 2015, Cheng et al, 2007, Evans et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

The microRNA network is altered in anterior cingulate cortex of patients with unipolar and bipolar depression

Azevedo

Carter

Meng

et al. 2016

Journal of Psychiatric Research

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MicroRNAs (miRNAs) are small, non-coding RNAs acting as post-transcriptional regulators of gene expression. Though implicated in multiple CNS disorders, miRNAs have not been examined in any psychiatric disease state in anterior cingulate cortex (AnCg), a brain region centrally involved in regulating mood. We performed qPCR analyses of 29 miRNAs previously implicated in psychiatric illness (major depressive disorder (MDD), bipolar disorder (BP) and/or schizophrenia (SZ)) in AnCg of patients with MDD and BP versus controls. miR-132, miR-133a and miR-212 were initially identified as differentially expressed in BP, miR-184 in MDD and miR-34a in both MDD and BP (although none survived multiple correction testing and must be considered preliminary). In silico target prediction algorithms identified putative targets of differentially expressed miRNAs. Nuclear Co-Activator 1 (NCOA1), Nuclear Co-Repressor 2 (NCOR2) and Phosphodiesterase 4B (PDE4B) were selected based upon predicted targeting by miR-34a (with NCOR2 and PDE4B both targeted by miR-184) and published relevance to psychiatric illness. Luciferase assays identified PDE4B as a target of miR-34a and miR-184, while NCOA1 and NCOR2 were targeted by miR-34a and 184, respectively. qPCR analyses were performed to determine whether changes in miRNA levels correlated with mRNA levels of validated targets. NCOA1 showed an inverse correlation with miR-34a in BP, while NCOR2 demonstrated a positive correlation. In sum, this is the first study to demonstrate miRNA changes in AnCg in psychiatric illness and validate miR-34a as differentially expressed in CNS in MDD. These findings support a mechanistic role for miRNAs in the regulation of stress-responsive genes disrupted in psychiatric illness.

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“…Studies with volumetric data are not that extensive. Anterior cingulate volumes have demonstrated to predict faster and higher symptom improvement after 8‐week fluoxetine treatment, and the caudal portion is correlated positively with symptom improvement in another study with a 16‐week cognitive behavioral therapy …”

Section: Discussionmentioning

confidence: 97%

Naturalistic Course of Major Depressive Disorder Predicted by Clinical and Structural Neuroimaging Data: A 5-Year Follow-Up

et al. 2016

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Anterior cingulate volume predicts response to cognitive behavioral therapy in major depressive disorder

Cited by 43 publications

References 17 publications

Venlafaxine treatment reduces the deficit of executive control of attention in patients with major depressive disorder

Venlafaxine treatment reduces the deficit of executive control of attention in patients with major depressive disorder

The microRNA network is altered in anterior cingulate cortex of patients with unipolar and bipolar depression

Naturalistic Course of Major Depressive Disorder Predicted by Clinical and Structural Neuroimaging Data: A 5-Year Follow-Up

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