Anterior cingulate cortex γ-aminobutyric acid deficits in youth with depression

Gabbay, Vilma; Bradley, Kailyn; Mao, Xiangling; Ostrover, Reynolds; Kang, Guoguo; Shungu, Dikoma C.

doi:10.1038/tp.2017.187

Cited by 72 publications

(73 citation statements)

References 48 publications

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“…A small percentage of studies (13.8%) included sex as a variable to assess potential interactions with STBs. Five studies (3.8%) reported sex-related findings, though no relationship with STBs [36,146,[193][194][195][196] and one study (0.8%) reported more females than males studied were SAs but reported no neuroimaging-related findings [197]. Chase et al [198], in a study that controlled for sex, noted that one participant identified as transmale.…”

Section: Future Directionsmentioning

confidence: 99%

Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

et al. 2019

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Identifying brain alterations that contribute to suicidal thoughts and behaviors (STBs) are important to develop more targeted and effective strategies to prevent suicide. In the last decade, and especially in the last 5 years, there has been exponential growth in the number of neuroimaging studies reporting structural and functional brain circuitry correlates of STBs. Within this narrative review, we conducted a comprehensive review of neuroimaging studies of STBs published to date and summarize the progress achieved on elucidating neurobiological substrates of STBs, with a focus on converging findings across studies. We review neuroimaging evidence across differing mental disorders for structural, functional, and molecular alterations in association with STBs, which converges particularly in regions of brain systems that subserve emotion and impulse regulation including the ventral prefrontal cortex (VPFC) and dorsal PFC (DPFC), insula and their mesial temporal, striatal and posterior connection sites, as well as in the connections between these brain areas. The reviewed literature suggests that impairments in medial and lateral VPFC regions and their connections may be important in the excessive negative and blunted positive internal states that can stimulate suicidal ideation, and that impairments in a DPFC and inferior frontal gyrus (IFG) system may be important in suicide attempt behaviors. A combination of VPFC and DPFC system disturbances may lead to very high risk circumstances in which suicidal ideation is converted to lethal actions via decreased top-down inhibition of behavior and/or maladaptive, inflexible decision-making and planning. The dorsal anterior cingulate cortex and insula may play important roles in switching between these VPFC and DPFC systems, which may contribute to the transition from suicide thoughts to behaviors. Future neuroimaging research of larger sample sizes, including global efforts, longitudinal designs, and careful consideration of developmental stages, and sex and gender, will facilitate more effectively targeted preventions and interventions to reduce loss of life to suicide.

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Section: Future Directionsmentioning

confidence: 99%

Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

et al. 2019

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“…The connection between gut microbiota and central nervous systems occurs by several pathways, which involve microbial metabolites (short-chain fatty acids), immune cells, tryptophan metabolism along with neural (vagus nerve), and endocrine pathways (the hypothalamic-pituitary-adrenal axis) [164,165]. Bacterial commensals in the gastrointestinal tract are also responsible for the production of γ-aminobutyric acid, which is the main inhibitory neurotransmitter in the central nervous system and may induce neuropsychiatric symptoms [166][167][168][169][170][171][172]. Dopamine, noradrenaline, and histamine, as well as brain-derived neurotrophic factor (BDNF) levels, can also be affected by gut microbiota [173].…”

Section: The Impact Of Gut Microbiota On the Cnsmentioning

confidence: 99%

Alterations in the Nervous System and Gut Microbiota after β-Hemolytic Streptococcus Group A Infection—Characteristics and Diagnostic Criteria of PANDAS Recognition

Baj

Sitarz

Forma

et al. 2020

IJMS

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The objective of this paper is to review and summarize conclusions from the available literature regarding Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS). The authors have independently reviewed articles from 1977 onwards, primarily focusing on the etiopathology, symptoms, differentiation between similar psychiatric conditions, immunological reactions, alterations in the nervous system and gut microbiota, genetics, and the available treatment for PANDAS. Recent research indicates that PANDAS patients show noticeable alterations within the structures of the central nervous system, including caudate, putamen, globus pallidus, and striatum, as well as bilateral and lentiform nuclei. Likewise, the presence of autoantibodies that interact with basal ganglia was observed in PANDAS patients. Several studies also suggest a relationship between the presence of obsessive-compulsive disorders like PANDAS and alterations to the gut microbiota. Further, genetic predispositions—including variations in the MBL gene and TNF-α—seem to be relevant regarding PANDAS syndrome. Even though the literature is still scarce, the authors have attempted to provide a thorough insight into the PANDAS syndrome, bearing in mind the diagnostic difficulties of this condition.

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“…This study used an integrated approach to measure group RSFC, cortical GABA+/Creatine (GABA + /Cr) concentrations and peripartum plasma NAS in women who developed PPD during pregnancy up to 8 weeks postpartum as compared to healthy peripartum women. Our main aims were to (1) examine RSFC networks with nodes in the ACC/MPFC due to previous reports of altered connectivity of regions within the DMN and SN [10]; (2) measure cortical GABA+/Cr in the pregenual (pg) ACC/MPFC given reduced pgACC GABA in MDD [28] (3) examine associations between pgACC GABA+/Cr and RSFC; and (4) measure peripartum NAS to examine their relationship with PPD, patterns of RSFC and pgACC GABA+/Cr. A validation aim was to measure GABA+/Cr in the OCC, given its use as a region of interest in MDD MRS studies [16] and to compare to the one previous PPD GABA MRS study [18].…”

Section: Introductionmentioning

confidence: 99%

Resting-state functional connectivity, cortical GABA, and neuroactive steroids in peripartum and peripartum depressed women: a functional magnetic resonance imaging and spectroscopy study

Deligiannidis

Fales

Kroll‐Desrosiers

et al. 2018

Neuropsychopharmacol

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Postpartum depression (PPD) is associated with abnormalities in resting-state functional connectivity (RSFC) but the underlying neurochemistry is unclear. We hypothesized that peripartum GABAergic neuroactive steroids (NAS) are related to cortical GABA concentrations and RSFC in PPD as compared to healthy comparison women (HCW). To test this, we measured RSFC with fMRI and GABA+/Creatine (Cr) concentrations with proton magnetic resonance spectroscopy ( 1 H MRS) in the pregenual anterior cingulate (pgACC) and occipital cortices (OCC) and quantified peripartum plasma NAS. We examined between-group differences in RSFC and the relationship between cortical GABA+/Cr concentrations with RSFC. We investigated the relationship between NAS, RSFC and cortical GABA+/Cr concentrations. Within the default mode network (DMN) an area of the dorsomedial prefrontal cortex (DMPFC) had greater connectivity with the rest of the DMN in PPD (peak voxel: MNI coordinates (2, 58, 32), p = 0.002) and was correlated to depression scores (peak HAM-D17 voxel: MNI coordinates (0, 60, 34), p = 0.008). pgACC GABA+/Cr correlated positively with DMPFC RSFC in a region spanning the right anterior/posterior insula and right temporal pole (r = +0.661, p = 0.000). OCC GABA+/Cr correlated positively with regions spanning both amygdalae (right amygdala: r = +0.522, p = 0.000; left amygdala: r = +0.651, p = 0.000) as well as superior parietal areas. Plasma allopregnanolone was higher in PPD (p = 0.03) and positively correlated with intra DMPFC connectivity (r = +0.548, p = 0.000) but not GABA+/Cr. These results provide initial evidence that PPD is associated with altered DMN connectivity; cortical GABA+/Cr concentrations are associated with postpartum RSFC and allopregnanolone is associated with postpartum intra-DMPFC connectivity.Neuropsychopharmacology (2019) 44:546-554; https://doi.org/10.1038/s41386-018-0242-2 (DMN) [8] and salience networks (SN) [9] in PPD [10]. The DMN is a network of connected brain regions most active at rest and involved in monitoring of the external environment and internal mentation. Although studies differ, this network often includes the medial prefrontal cortex (MPFC), posterior cingulate cortex, precuneus and inferior parietal lobule [11]. The SN is a paralimbic-limbic network active both at rest and during taskrelated activity which integrates sensory, emotional and cognitive information to contribute to social behavior and self-awareness. The SN often includes the dorsal ACC, anterior insula, amygdala, ventral striatum, dorsomedial thalamus, hypothalamus and the substantia nigra/ventral tegmental area [12] Γ-aminobutyric acid (GABA) is believed to contribute to intrinsic functional connectivity of a network [13][14][15] and has been

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Anterior cingulate cortex γ-aminobutyric acid deficits in youth with depression

Cited by 72 publications

References 48 publications

Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

Alterations in the Nervous System and Gut Microbiota after β-Hemolytic Streptococcus Group A Infection—Characteristics and Diagnostic Criteria of PANDAS Recognition

Resting-state functional connectivity, cortical GABA, and neuroactive steroids in peripartum and peripartum depressed women: a functional magnetic resonance imaging and spectroscopy study

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