Abstract:Schizophrenia is associated with deficits in memory, behavioural flexibility, and motivation, which can result in difficulties in decision-making. The anterior cingulate cortex (ACC) and ventral tegmental area (VTA) are two brain regions that are involved in decision-making, and display dysfunction in schizophrenia. We investigated ACC and VTA activity in the maternal immune activation (MIA) model of a schizophrenia risk factor. Control and MIA rats completed a cost-benefit decision-making task in a continuous… Show more
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