Anterior cingulate cortex: An MRI-based parcellation method

McCormick, Laurie M.; Ziebell, Steven; Nopoulos, Peg; Cassell, Martin D.; Andreasen, Nancy C.; Brumm, Michael C.

doi:10.1016/j.neuroimage.2006.04.227

Cited by 75 publications

(77 citation statements)

References 38 publications

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“…Masks were binarized images of the NAcc, insula, dACC, thalamus, OFC, and caudate from the Harvard-Oxford Cortical and Subcortical Probability Atlas, set at a probability of 50%. For the dACC, the subgenual part of the ACC was removed at MNI coordinate y ¼ 32 (McCormick et al, 2006). Thresholding was performed using GRF-theory-based maximum height thresholding, with a corrected significance threshold of p ¼ 0.05 (Worsley, 2001).…”

Section: Data Processing and Analysismentioning

confidence: 99%

Dopamine Modulates Reward System Activity During Subconscious Processing of Sexual Stimuli

Oei

Rombouts

Soeter

et al. 2012

Neuropsychopharmacol

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Dopaminergic medication influences conscious processing of rewarding stimuli, and is associated with impulsive-compulsive behaviors, such as hypersexuality. Previous studies have shown that subconscious subliminal presentation of sexual stimuli activates brain areas known to be part of the 'reward system'. In this study, it was hypothesized that dopamine modulates activation in key areas of the reward system, such as the nucleus accumbens, during subconscious processing of sexual stimuli. Young healthy males (n ¼ 53) were randomly assigned to two experimental groups or a control group, and were administered a dopamine antagonist (haloperidol), a dopamine agonist (levodopa), or placebo. Brain activation was assessed during a backward-masking task with subliminally presented sexual stimuli. Results showed that levodopa significantly enhanced the activation in the nucleus accumbens and dorsal anterior cingulate when subliminal sexual stimuli were shown, whereas haloperidol decreased activations in those areas. Dopamine thus enhances activations in regions thought to regulate 'wanting' in response to potentially rewarding sexual stimuli that are not consciously perceived. This running start of the reward system might explain the pull of rewards in individuals with compulsive reward-seeking behaviors such as hypersexuality and patients who receive dopaminergic medication.

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Section: Data Processing and Analysismentioning

confidence: 99%

Dopamine Modulates Reward System Activity During Subconscious Processing of Sexual Stimuli

Oei

Rombouts

Soeter

et al. 2012

Neuropsychopharmacol

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“…For the volumetric measurements of BA24sg (SGPFC), we relied primarily on the protocol of Drevets et al (1997), but also benefited from the studies of McCormick et al (2006) and Fornito et al (2008) as well as the human brain atlas of Mai et al (1997). We used previously published studies (Bremner et al, 2002;McCormick et al, 2006) and the human brain atlas of Mai et al (1997) to measure the volume of BA25. The most posterior border on the coronal plane was set as the slice anterior to the slice where putamen was first visible and the most anterior border was the anterior most point of the corpus callosum (rostral tip of the genu).…”

Section: Ventral-rostral Acc Measurementmentioning

confidence: 99%

“…The inferior border was the cingulate sulcus. We used previously published studies (Bremner et al, 2002;McCormick et al, 2006) and the human brain atlas of Mai et al (1997) to measure the volume of BA25 (subcallosal gyrus). We set our anterior border coronally as the last slice in which internal capsule was visible, separating the caudate from the putamen; in other words the first slice in which putamen was visible.…”

Section: Ventral-rostral Acc Measurementmentioning

confidence: 99%

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Anterior Cingulate Volumes in Never-Treated Patients with Major Depressive Disorder

Yücel

McKinnon

Chahal

et al. 2008

Neuropsychopharmacol

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The anterior cingulate cortex (ACC) is implicated in the cognitive and affective abnormalities observed in mood disorders. Bilateral ACC volume reductions have been reported in patients with major depressive disorder (MDD) when compared to healthy controls. We compared regional brain volumes in the subgenual prefrontal cortex (SGPFC; Brodmann area (BA) 24 sg ), subcallosal gyrus (BA25), and paracingulate gyrus (BA32) in 65 patients receiving a first course of treatment for MDD and 93 healthy control subjects. Patients with more than three episodes of untreated MDD had smaller subcallosal gyrus volumes than healthy controls, while those with three or fewer past untreated episodes did not differ from controls. We also found preliminary evidence that medication-exposed patients had smaller SGPFC volumes than patients with no exposure to medication and healthy controls. There was no evidence that these effects related to mood state, duration of untreated illness, or to patient age. No differences were apparent in paracingulate gyrus volumes between patients and controls. These findings confirm the presence of ACC volume reductions in untreated patients with MDD and suggest that illness burden and short-term medication exposure mediate this change.

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“…17 Interestingly, one study found that the volume and the cortical thickness in subparts of this region were related to the morphologic characteristics of the cingulate and paracingulate sulcus. 18 Thus, if a paracingulate sulcus was present, then an increase in paracingulate cortex and decrease of anterior cingulate cortex volume was found in the same hemispheres.…”

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confidence: 99%

A Comparison Between Volumetric Data Generated by Voxel-Based Morphometry and Manual Parcellation of Multimodal Regions of the Frontal Lobe

Lindberg

Manzouri

Westman

et al. 2012

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Volumetric measurements on structural MR images are an established method to investigate pathology-related volume changes in cortex. Manual volumetric methods have sometimes been referred to as the reference standard for quality control of automatic volumetric methods. While some automatic methods, like VBM, may rely on a template, manual methods use sulci as indirect landmarks for the subdivision of cortex. The purpose of this study was to compare volumetric data generated by MM and VBM on 4 multimodal regions in the frontal lobe.

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Anterior cingulate cortex: An MRI-based parcellation method

Cited by 75 publications

References 38 publications

Dopamine Modulates Reward System Activity During Subconscious Processing of Sexual Stimuli

Dopamine Modulates Reward System Activity During Subconscious Processing of Sexual Stimuli

Anterior Cingulate Volumes in Never-Treated Patients with Major Depressive Disorder

A Comparison Between Volumetric Data Generated by Voxel-Based Morphometry and Manual Parcellation of Multimodal Regions of the Frontal Lobe

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