Anterior Chamber of the Eye

Alsbirk, Poul Helge

doi:10.1159/000152755

Cited by 19 publications

(1 citation statement)

References 8 publications

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“…Female gender was also associated with having shallower ACD than males. This is also in keeping with other studies 5,15,18 and confirms the long-term belief that females have lower ACD measurements than males. This association remained statistically significant after adjustment for body height, weight and body mass index.…”

Section: Discussionsupporting

confidence: 92%

<p>Ocular Biometry and Their Correlations with Ocular and Anthropometric Measurements Among Ethiopian Adults</p>

Gessesse

Debela

Anbesse

2020

OPTH

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Purpose: To determine the average values of ocular biometry dimensions and investigate their inter-correlations and their association with anthropometric measurements among Ethiopian adults with healthy eyes. Methods: A cross-sectional study was undertaken from June 2018 to July 2019. A total of 400 eyes of 200 subjects were included in the study. Univariable and multivariable linear regression were used to determine the association of demographic variables (age and sex) and anthropometric parameters (height, weight and BMI) with ocular biometric indices. Results: The mean age was 40.31±11.39 with a range from 18 to 69 years. The mean (SD) of horizontal corneal diameter, average corneal refractive power, anterior chamber depth (ACD), lens thickness (LT) and axial length (AL) were 11.45 (0.89) mm, 43.94 (9.78) diopter, 2.91 (0.43) mm, 4.29 (0.55) mm and 22.96 (0.82) mm, respectively. Age had a negative correlation with ACD (r= −0.196, p= <0.001) and positive correlation with lens thickness (r= 0.324, p<0.001). Height had a positive correlation with ACD (r=0.114, p=0.023) and LT (r= 0.206, p=<0.001) while negative correlation with LT (r=−0.129, p=0.01). In the multivariate linear regression, age (−0.009 (−0.013, −0.05), p-value <0.001) and sex (0.104 (0.01, 0.198), p-value=0.03) had a significant association with ACD and only gender (0.478 (0.302, 0.654), p-value <0.001) had a statistically significant association with lens thickness. Conclusion: This study determined the normative values for ocular biometric parameters among Ethiopian adults for the first time. Age, gender and height were associated with biometric indices. AL was significantly positively correlated with ACD and negatively correlated with LT. There was a negative correlation between LT and both AL and ACD.

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Section: Discussionsupporting

confidence: 92%

<p>Ocular Biometry and Their Correlations with Ocular and Anthropometric Measurements Among Ethiopian Adults</p>

Gessesse

Debela

Anbesse

2020

OPTH

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Confirmation of Linkage to Ocular Refraction on Chromosome 22q and Identification of a Novel Linkage Region on 1q

Klein¹,

Duggal

Lee

et al. 2007

Arch Ophthalmol

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To localize genes influencing ocular refraction in subjects in the Beaver Dam Eye Study. Previous studies establish that myopia clusters within families and linkage to myopia has been demonstrated on 2q, 4q, 12q, 17q, 18q, 22q, and Xq. Few studies have examined genetic effects across the entire range of refraction, though linkages to 1p, 3q, 4q, 8p, and 11p have been reported, and our previous analysis of the Beaver Dam Eye Study demonstrated substantial heritability for refraction (68%). Methods: We conducted nonparametric sibling-pair and genome-wide linkage analyses on spherical equivalent adjusting for age, education, and nuclear sclerosis, in 834 sibling pairs in 486 extended pedigrees. Results: We identified a novel region of suggestive linkage on 1q (multipoint, PϽ.00019) and replicated the 22q region (multipoint, P=.0033) previously linked to myopia. Additionally, there was some evidence of linkage to 7p (multipoint, P=.0023). Conclusion: Refraction is a complex trait influenced by both genes and environment. Our work confirms a previously reported linkage region on 22q and identifies 2 novel regions of linkage on 1q and 7p. Clinical Relevance: Further, genetic research is needed to finemap this trait to identify the causative gene. Modifying the actions of such a gene might lead to a reduction in the risk of refractive error.

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Secular Change in Anterior Chamber Depth, A Refractive Component of High Heritability

Alsbirk

1981

Documenta Ophthalmologica Proceedings Series

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Anterior Chamber of the Eye

Cited by 19 publications

References 8 publications

<p>Ocular Biometry and Their Correlations with Ocular and Anthropometric Measurements Among Ethiopian Adults</p>

<p>Ocular Biometry and Their Correlations with Ocular and Anthropometric Measurements Among Ethiopian Adults</p>

Confirmation of Linkage to Ocular Refraction on Chromosome 22q and Identification of a Novel Linkage Region on 1q

Secular Change in Anterior Chamber Depth, A Refractive Component of High Heritability

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