Antepartum and postpartum uterine artery impedance in women with pre-eclampsia: a case control study

Maged, Ahmed M.; Shoab, Amira Y; Dieb, Amira S.

doi:10.1080/01443615.2018.1563054

Cited by 5 publications

(5 citation statements)

References 21 publications

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“…Although ROS production is known to be induced by ischemic placenta in PE, ROS are also produced by systemic blood vessels during the second phase of PE onset. In some studies, placental homogenates derived from patients with PE show 39% higher hydrogen peroxide production than those derived from normal pregnant women [3,25]. We also found a significant increase in the level of H 2 O 2 in a mouse model of PE induced by Hif-1α.…”

Section: Overexpression Of Dram1 Promotes Mitochondrial Fusion Fissisupporting

confidence: 62%

“…Preeclampsia (PE) is characterized by hypertension with or without proteinuria after the 20th week of pregnancy and is associated with endothelial dysfunction, oxidative stress, systemic vasoconstriction, inflammation, intrauterine growth restriction, and multiorgan dysfunction [1,2]. The World Health Organization reports that more than 60,000 pregnant women worldwide die of eclampsia each year [3]. Women with PE and their offspring have an increased risk of developing cardiovascular disease later in life [4].…”

Section: Introductionmentioning

confidence: 99%

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The role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice

Lin

Chen

Zeng

et al. 2019

Preprint

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Background: Preeclampsia (PE) is a pregnancy complication that is diagnosed by the new onset of hypertension and proteinuria. Although the pathogenesis of PE is still not fully understood, growing evidence indicates that oxidative stress and mitochondrial dysfunction may contribute to the progression of PE. Therefore, we aimed to determine the role of mitophagy in mitochondrial dysfunction and oxidative stress in PE. Moreover, we aimed to evaluate the role of DNA damage-regulated autophagy modulator 1 (DRAM1) in the development of PE. Results: In this study, we first constructed a mouse model of PE induced by Hif-1α and found a high level of oxidative stress, apoptosis and mitochondrial dysfunction in the placentas of PE mice. Additionally, the activity of mitophagy was decreased, and the level of DRAM1 was significantly decreased in the placentas of PE mice. To further explore the role of DRAM1 in mitophagy, DRAM1 was overexpressed in the placental tissues of PE mice. It was found that the overexpression of DRAM1 effectively improved the symptoms of PE mice and that blood lipid and urine protein levels were significantly reduced. Furthermore, DRAM1 overexpression also improved mitochondrial function and reduced oxidative stress in the placentas of PE mice. In addition, it improved mitochondrial fusion and fission and enhanced mitophagy.Conclusions: our results indicate a key role of DRAM1 in mitophagy in contributing to the regulation of PE. To our knowledge, this is the first study to confirm the role of DRAM1 in PE, and the study provides a new understanding of the pathophysiological mechanisms of PE.

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Section: Overexpression Of Dram1 Promotes Mitochondrial Fusion Fissisupporting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

The role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice

Lin

Chen

Zeng

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Decreased placental blood flow can cause fetal acidosis, which can lead to chronic fetal hypoxemia 19 . These changes may also occur in preeclampsia, where fetoplacental blood flow is severely impaired, and transplacental gas exchange is weakened 20–22 . Many studies have shown that the prevalence of fetal acidosis is higher in pregnant women complicated with preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Cord blood gas results of pregnancies complicated by preeclampsia and the relationship of these results with the amount of proteinuria

Demir

Şal

Özalp

et al. 2021

J of Obstet and Gynaecol

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Aim To evaluate whether there is a statistically significant difference between the cord blood gas parameters of pregnancies complicated with preeclampsia and uncomplicated pregnancies and to show whether the amount of proteinuria affects fetal cord blood gas parameters in pregnancies complicated with preeclampsia. Methods The study was designed retrospectively. Between 2016 and 2019, the neonatal results and cord blood gas results of 109 pregnant women who were diagnosed with preeclampsia and 75 nonpreeclamptic randomly selected pregnant women were compared. The preeclampsia group was divided into groups according to amount of proteinuria. SPSS 21.0 statistics program was used, and comparative analysis was carried out. Results The data of the 109 preeclampsia cases and 75 control groups included in the study were compared, and there was no statistical difference between the fetal cord blood gas parameters between the groups (p > 0.05). The median first and fifth minute Apgar scores were found significantly lower in the preeclampsia group compared to the control group (6, 8 and 8, 9, respectively; p < 0.001). Also, the amount of proteinuria does not alter cord blood gas parameters (p > 0.05). Conclusion Preeclampsia poses a risk for the neonatal period as it reduces the neonatal Apgar scores due to the chronic hypoxic process it creates. However, it was observed that the amount of proteinuria, which is one of the diagnostic criteria, did not affect neonatal results on Apgar scores or fetal cord blood gas parameters.

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“…Although ROS production is known to be induced by the ischemic placenta in PE, ROS are also produced by systemic blood vessels during the second phase of PE onset ( 12 ). Certain studies have revealed that placental homogenates derived from patients with PE show 39% higher H 2 O 2 production than those derived from healthy pregnant women ( 3 , 42 ). The present study also found a significant increase in the level of H 2 O 2 in a mouse model of PE induced by Hif-1α.…”

Section: Discussionmentioning

confidence: 99%

“…Preeclampsia (PE) is characterized by hypertension with or without proteinuria after the 20th week of pregnancy, and is associated with endothelial dysfunction, oxidative stress, systemic vasoconstriction, inflammation, intrauterine growth restriction and multiorgan dysfunction ( 1 , 2 ). The World Health Organization reports that >60,000 pregnant women worldwide die of preeclampsia each year ( 3 ). Women with PE and their offspring are also at increased risk of developing cardiovascular disease later in life ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice

et al. 2020

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Preeclampsia (Pe) is a complication during pregnancy that is diagnosed by a new onset of hypertension and proteinuria. although the pathogenesis of Pe is not fully understood, a growing body of evidence indicates that oxidative stress and mitochondrial dysfunction might contribute to the progression of Pe. Therefore, the aim of the present study was to determine the role of mitophagy in mitochondrial dysfunction and oxidative stress in Pe, and to evaluate the role of dna damage-regulated autophagy modulator 1 (draM1) in the development of Pe. First, a mouse model of Pe induced by hypoxia-inducible factor 1α was established, and high levels of oxidative stress, apoptosis and mitochondrial dysfunction were found in the placentas of Pe mice. additionally, the placentas of Pe mice exhibited decreased mitophagy and significantly decreased DRAM1 expression. To further explore the role of draM1 in mitophagy, draM1 was overexpressed in the placental tissues of Pe mice, and this overexpression effectively improved the symptoms of Pe mice and significantly reduced blood lipid and urine protein levels. draM1 overexpression also improved mitochondrial function and reduced oxidative stress in the placentas of Pe mice. in addition, the overexpression of draM1 improved mitochondrial fusion and fission, and enhanced mitophagy. altogether, these results indicated a key role for draM1 in mitophagy that contributed to the regulation of Pe. To the best of the authors' knowledge, the present study provided the first evidence of a role for draM1 in Pe, and offered novel insight into the pathophysiological mechanisms of Pe.

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Antepartum and postpartum uterine artery impedance in women with pre-eclampsia: a case control study

Cited by 5 publications

References 21 publications

The role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice

The role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice

Cord blood gas results of pregnancies complicated by preeclampsia and the relationship of these results with the amount of proteinuria

Role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice

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