Antepartum and postpartum maternal plasma levels of E-selectin and VE-cadherin in preeclampsia, gestational proteinuria and gestational hypertension

Papakonstantinou, Katerina; Economou, Emanouel; Koupa, Elena; Babameto, Ilias; Hasiakos, D; Vitoratos, N.

doi:10.3109/14767058.2010.545907

Cited by 6 publications

(7 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cellular forms of these molecules can be detected in the blood, and their levels are altered dramatically in conditions such as sepsis, acute coronary syndromes and rheumatoid arthritis [9]. Circulating concentrations of the adhesion molecules P-selectin [9,10], vascular cellular adhesion molecule-1 (VCAM-1 [11,12]), E-selectin [9,10,13] and intercellular adhesion molecule-1 (ICAM-1 [9]) are reported to be elevated in women with established preeclampsia, indicating endothelial dysfunction. Few studies have examined these molecules in longitudinal studies throughout pregnancy.…”

mentioning

confidence: 98%

Early pregnancy soluble E-selectin concentrations and risk of preeclampsia

Carty

Anderson

Freeman

et al. 2012

Journal of Hypertension

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 98%

Early pregnancy soluble E-selectin concentrations and risk of preeclampsia

Carty

Anderson

Freeman

et al. 2012

Journal of Hypertension

View full text Add to dashboard Cite

show abstract

“…In a small study of 12 women with severe PE, there was a significant increase in soluble E-selectin (sE-selectin) in cases compared to controls at 3-6 days and then 12-15 weeks postpartum. 51 Similarly, Chambers et al reported higher levels in cases 3 years postpartum. 42 Nonetheless, other studies have demonstrated no difference in sE-selectin at 1 and 2.5 years postpartum when comparing cases and controls.…”

Section: Biomarkers Of Endothelial Function Soluble Intercellular Adh...mentioning

confidence: 90%

Novel Cardiovascular Biomarkers Associated with Increased Cardiovascular Risk in Women With Prior Preeclampsia/HELLP Syndrome: A Narrative Review

2021

View full text Add to dashboard Cite

Evidence has shown that women with a history of preeclampsia or haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome have an increased risk of cardiovascular disease later in life. Recommendations for screening, prevention and management after such pregnancies are not yet defined. The identification of promising non-traditional cardiovascular biomarkers might be useful to predict which women are at greatest risk. Many studies are inconsistent and an overview of the most promising biomarkers is currently lacking. This narrative review provides an update of the current literature on circulating cardiovascular biomarkers that may be associated with an increased cardiovascular disease risk in women after previous preeclampsia/HELLP syndrome. Fifty-six studies on 53 biomarkers were included. From the summary of evidence, soluble fms-like tyrosine kinase-1, placental growth factor, interleukin (IL)-6, IL-6/IL-10 ratio, high-sensitivity cardiac troponin I, activin A, soluble human leukocyte antigen G, pregnancy-associated plasma protein A and norepinephrine show potential and are interesting candidate biomarkers to further explore. These biomarkers might be potentially eligible for cardiovascular risk stratification after preeclampsia/HELLP syndrome and may contribute to the development of adequate strategies for prevention of hypertension and adverse events in this population.

show abstract

“…The most indicative marker of endothelium damage and dysfunction seems to be the soluble E-selectin (sE-selectin) ( Figure 3 ) [ 43 ]. Increased serum concentration of sE-selectin in patients with PE in comparison to normotensive pregnant women was identified in multiple studies [ 37 , 43 , 46 , 47 , 48 ]. Interestingly, in the study by Papakonstantinou et al [ 46 ] these differences were observed only in patients with PE, and not in patients with gestational hypertension.…”

Section: Discussionmentioning

confidence: 99%

“…Increased serum concentration of sE-selectin in patients with PE in comparison to normotensive pregnant women was identified in multiple studies [ 37 , 43 , 46 , 47 , 48 ]. Interestingly, in the study by Papakonstantinou et al [ 46 ] these differences were observed only in patients with PE, and not in patients with gestational hypertension. On the other hand, Mistry et al [ 43 ] observed a significantly higher level of sE-selectin in patients with EOP compared to patients with LOP, which indicates a correlation between levels of this marker and severity of the disease.…”

Section: Discussionmentioning

confidence: 99%

Endothelial Dysfunction in Pregnancy Complications

et al. 2021

View full text Add to dashboard Cite

The endothelium, which constitutes the inner layer of blood vessels and lymphatic structures, plays an important role in various physiological functions. Alterations in structure, integrity and function of the endothelial layer during pregnancy have been associated with numerous gestational complications, including clinically significant disorders, such as preeclampsia, fetal growth restriction, and diabetes. While numerous experimental studies have focused on establishing the role of endothelial dysfunction in pathophysiology of these gestational complications, their mechanisms remain unknown. Numerous biomarkers of endothelial dysfunction have been proposed, together with the mechanisms by which they relate to individual gestational complications. However, more studies are required to determine clinically relevant markers specific to a gestational complication of interest, as currently most of them present a significant overlap. Although the independent diagnostic value of such markers remains to be insufficient for implementation in standard clinical practice at the moment, inclusion of certain markers in predictive multifactorial models can improve their prognostic value. The future of the research in this field lies in the fine tuning of the clinical markers to be used, as well as identifying possible therapeutic techniques to prevent or reverse endothelial damage.

show abstract

Antepartum and postpartum maternal plasma levels of E-selectin and VE-cadherin in preeclampsia, gestational proteinuria and gestational hypertension

Cited by 6 publications

References 30 publications

Early pregnancy soluble E-selectin concentrations and risk of preeclampsia

Early pregnancy soluble E-selectin concentrations and risk of preeclampsia

Novel Cardiovascular Biomarkers Associated with Increased Cardiovascular Risk in Women With Prior Preeclampsia/HELLP Syndrome: A Narrative Review

Endothelial Dysfunction in Pregnancy Complications

Contact Info

Product

Resources

About