Antenatal screening for haemoglobinopathies in primary care: a cohort study and cluster randomised trial to inform a simulation model. The Screening for Haemoglobinopathies in First Trimester (SHIFT) trial

Abstract

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Measuring informed choice in population-based reproductive genetic screening: a systematic review

“…[20][21][22][23][24][25] In total, 34 articles met the inclusion criteria; data were extracted for 33 articles as two studies reported the same data on informed choice. 26,27 The final inclusion of papers was confirmed by the authors JE and SAM.…”

Enhanced invitation methods and uptake of health checks in primary care: randomised controlled trial and cohort study using electronic health records

“…In total, 12,459 participants were allocated, 8571 through the in-practice recruitment method and 3888 through the fully automated recruitment method. The median age of participants was 45 (interquartile range [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54] years, 33% were in the most deprived quintile of deprivation for England and 39% were of 'white' ethnicity, with no differences among trial arms.…”

“…For example, they have failed to increase the uptake of colorectal cancer screening among first-time invitees 39 or antenatal screening. 40 In field settings, a substantial proportion of participants asked to do so may not record a plan. 41 Moreover, plan formation has been shown to be most effective for individuals who are already motivated to perform the behaviour, 42 for example those who accepted a previous round of colorectal cancer screening.…”

Screening for sickle cell and thalassaemia in primary care: a cost-effectiveness study

“…Full details of the trial design and results are reported elsewhere. 2,3 The economic analysis in SHIFT sought to predict the costs and benefits associated with the three strategies, in populations similar to those observed in the trial. An incremental analysis was adopted, the increment being the difference in costs and benefits between trial arms, with 'midwife care' as the default comparator.…”

“…The main finding was that offering SCT screening in primary care was effective (that is, the proportion of women screened before 10 weeks' gestation) but still only a minority of women were screened before 10 weeks. 2,3 The trial was supplemented with a modelbased cost-effectiveness analysis that sought to estimate the additional costs associated with primary care screening, both sequential and parallel, and the benefits in terms of the number of additional women screened before 10 weeks' gestation. This paper reports the costeffectiveness component of the SHIFT trial.…”