Antenatal Magnesium Sulfate and adverse gastrointestinal outcomes in Preterm infants—a systematic review and meta-analysis

Prasath, Arun; Aronoff, Nell; Chandrasekharan, Praveen; Diggikar, Shivashankar

doi:10.1038/s41372-023-01710-8

Cited by 3 publications

(2 citation statements)

References 76 publications

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“…MgSO 4 exposure has also previously been associated with a rise in the incidence of low Apgar scores, hypotonia, and neonatal intensive care unit (NICU) admission. Other studies demonstrated that exposure to antenatal MgSO 4 in preterm infants did not affect the need for resuscitation at birth or other short-term outcomes such as hypotonia, respiratory distress syndrome (RDS), need of mechanical ventilation, gastrointestinal-related morbidities, IVH or death [16,18,19,20] .These outcomes are aligned with our ndings.…”

Section: Discussionsupporting

confidence: 89%

Antenatal Exposure to Magnesium Sulphate and Neonatal Outcomes in Very Low Birth Weight Infants: a multicenter study.

Ferreira,

Caro,

Villarroel

et al. 2023

Preprint

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Objective To explore the association between antenatal magnesium sulphate ( MgSO4 ), mortality and incidence of intraventricular hemorrhage (IVH) in very low birth weight (VLBW) infants.Study design Retrospective, cohort study of infants < 32 weeks’ GA born at centers of NEOCOSUR Network between January 2015 and December 2020. Subjects were categorized as exposed vs non-exposed to antenatal MgSO4. Primary outcomes were death, incidence of severe IVH (Grade III-IV) and severe IVH/death. Secondary outcomes included relevant morbidities.Results 7418 VLBW infants were eligible. Antenatal MgSO4 was associated with a significantly decreased death rate after admission (aOR 0.59 [95% CI, 0.46–0.74]) and severe IVH/ death (aOR 0.63 [95% CI, 0.49–0.83]). No significant reduction in severe IVH was observed (aOR 0.89 [95% CI, 0.63–1.25]). No differences between groups were observed in rates of morbidities.Conclusion Antenatal MgSO4 was associated with a decreased death rate after admission and in severe IVH/ death.

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Section: Discussionsupporting

confidence: 89%

Antenatal Exposure to Magnesium Sulphate and Neonatal Outcomes in Very Low Birth Weight Infants: a multicenter study.

Ferreira,

Caro,

Villarroel

et al. 2023

Preprint

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show abstract

“… 56 A recent meta-analysis of 38 non-randomized studies and six randomized trials involving 51,466 preterm infants did not, however, show an increase in gastro-intestinal pathology. 57 …”

Section: Antenatal Managementmentioning

confidence: 99%

Neuroprotective therapies in the NICU in preterm infants: present and future (Neonatal Neurocritical Care Series)

Molloy,

El-Dib,

Soul

et al. 2023

Pediatr Res

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The survival of preterm infants has steadily improved thanks to advances in perinatal and neonatal intensive clinical care. The focus is now on finding ways to improve morbidities, especially neurological outcomes. Although antenatal steroids and magnesium for preterm infants have become routine therapies, studies have mainly demonstrated short-term benefits for antenatal steroid therapy but limited evidence for impact on long-term neurodevelopmental outcomes. Further advances in neuroprotective and neurorestorative therapies, improved neuromonitoring modalities to optimize recruitment in trials, and improved biomarkers to assess the response to treatment are essential. Among the most promising agents, multipotential stem cells, immunomodulation, and anti-inflammatory therapies can improve neural outcomes in preclinical studies and are the subject of considerable ongoing research. In the meantime, bundles of care protecting and nurturing the brain in the neonatal intensive care unit and beyond should be widely implemented in an effort to limit injury and promote neuroplasticity. Impact With improved survival of preterm infants due to improved antenatal and neonatal care, our focus must now be to improve long-term neurological and neurodevelopmental outcomes. This review details the multifactorial pathogenesis of preterm brain injury and neuroprotective strategies in use at present, including antenatal care, seizure management and non-pharmacological NICU care. We discuss treatment strategies that are being evaluated as potential interventions to improve the neurodevelopmental outcomes of infants born prematurely.

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Antenatal exposure to magnesium sulfate and neonatal outcomes in very low birth weight infants: a multicenter study

Vaz Ferreira,

Caro,

Villarroel

et al. 2024

J Perinatol

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Antenatal Magnesium Sulfate and adverse gastrointestinal outcomes in Preterm infants—a systematic review and meta-analysis

Cited by 3 publications

References 76 publications

Antenatal Exposure to Magnesium Sulphate and Neonatal Outcomes in Very Low Birth Weight Infants: a multicenter study.

Antenatal Exposure to Magnesium Sulphate and Neonatal Outcomes in Very Low Birth Weight Infants: a multicenter study.

Neuroprotective therapies in the NICU in preterm infants: present and future (Neonatal Neurocritical Care Series)

Antenatal exposure to magnesium sulfate and neonatal outcomes in very low birth weight infants: a multicenter study

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